ISOPILOCARPINE Property

Boiling point:

261 °C/IO mm

pka

pKa 7.18(H2O,t =15) (Uncertain)

Hazard and Precautionary Statements (GHS)

ISOPILOCARPINE Chemical Properties,Usage,Production

Description

The leaves of Pilocarpus pennatifolius Lem. and P. jaborandi Holmes contain this alkaloid which is a colourless oily liquid. A number of salts and derivatives have been prepared, e.g. the hydrochloride hemihydrate, m.p. 127°C or 159°C (dry); hydrobromide, m.p. 147°C; nitrate, m.p. 159°C; aurichloride, m.p. 158-9°C; platinichloride, m.p. 226-7°C; picrate, m.p. 161°C and the methiodide, m.p. 114°C.

References

Jowett.,J. Chern. Soc., 77, 483 (1900) Jowett., ibid, 87, 794 (1905) Burtles, Pyman, Roylance., ibid, 581 (1925) Preobrashenski, Wompe, Preobrashenski., Ber., 66, 1187 (1933) Poljakova et al., ibid, 69, 1314 (1936) DeY.,J. Chern. Soc., 1057 (1937) Preobrashenski., Chern. Abstr., 47,4345 (1953)