ChemicalBook > CAS DataBase List > TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN

TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN

Product Name
TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN
CAS No.
98474-59-0
Chemical Name
TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN
Synonyms
des-Gly77;MYELIN BASIC PROTEIN, FRAGMENT 68-82;MYELIN BASIC PROTEIN (68-82), GUINEA PIG;(Des-Gly77,Des-His78)-MBP (68-84) (bovine);MYELIN BASIC PROTEIN MBP (68-82), GUINEA PIG;MYELIN BASIC PROTEIN FRAGMENT 68-82 GUINEA PIG;myelin basic protein guinea pig fragment 68-82;(Des-Gly77,Des-His78)-MBP (68-84) (guinea pig);MBP (68-82),Myelin Basic Protein (68-84), guinea pig;DES[GLY77,HIS78]-MYELIN BASIC PROTEIN, FRAGMENT 68-64
CBNumber
CB8721158
Molecular Formula
C71H113N23O28
Formula Weight
1736.81
MOL File
98474-59-0.mol
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TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN Property

storage temp. 
-20°C
solubility 
insoluble in EtOH; ≥173.6 mg/mL in DMSO; ≥54.6 mg/mL in H2O
form 
solid
Sequence
H-Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn-OH
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M3755
Product name
Myelin Basic Protein Guinea Pig Fragment 68-82
Purity
≥97% (HPLC)
Packaging
1mg
Price
$493.8
Updated
2024/03/01
Alfa Aesar
Product number
J66176
Product name
Des-[Gly<sup>7</sup><sup>7</sup>, His<sup>7</sup><sup>8</sup>] Myelin Basic Protein (68-84), bovine
Packaging
1mg
Price
$109
Updated
2021/12/16
ApexBio Technology
Product number
A1031
Product name
MyelinBasicProtein(68-82),guineapig
Packaging
10mg
Price
$110
Updated
2021/12/16
ApexBio Technology
Product number
A1031
Product name
MyelinBasicProtein(68-82),guineapig
Packaging
25mg
Price
$154
Updated
2021/12/16
ApexBio Technology
Product number
A1031
Product name
MyelinBasicProtein(68-82),guineapig
Packaging
5mg
Price
$66
Updated
2021/12/16
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TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN Chemical Properties,Usage,Production

Biological Activity

myelin basic protein (68-82), guinea pig,(c71h113n23o28) is a peptide with the sequence tyr-gly-ser-leu-pro-gln-lys-ser-gln-arg-ser-gln-asp-glu-asn, mw= 1736.79. myelin basic protein (mbp) is a protein believed to be important in the process of myelination of nerves in the nervous system. knockout mice deficient in mbp showed decreased amounts of cns myelination and have developed a progressive disorder characterized by tremors, seizures, and early death. mbp research has centered on its role in demyelinating diseases, in particular, multiple sclerosis (ms). several studies have uncovered the role of antibodies against mbp in the pathogenesis of ms.] some studies have linked a genetic predisposition to ms to the mbp gene, though a majority have not. some recent work has shown that inoculating an animal with mbp to generate an immune response against it increases blood–brain barrier permeability.figure1 formula of myelin basic protein (68-82), guinea pigfigure2 structure of myelin basic protein

Biochem/physiol Actions

Myelin basic protein fragment that induces experimental allergic encephalomyelitis.

References

1. Sakamoto Y, Kitamura K, Yoshimura K, Nishijima T, Uyemura K (March 1987). "Complete amino acid sequence of POprotein in bovine peripheral nerve myelin". J. Biol. Chem. 262 (9): 4208–14.2. Deber CM, Reynolds SJ (April 1991). "Central nervous system myelin: structure, function, and pathology". Clin. Biochem. 24 (2): 113–34.3. Inouye H, Kirschner DA (January 1991). "Folding and function of the myelin proteins from primary sequence data". J. Neurosci. Res. 28 (1): 1–17.4. Berger T, Rubner P, Schautzer F, Egg R, Ulmer H, Mayringer I, Dilitz E, Deisenhammer F, Reindl M (July 2003). "Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event". N. Engl. J. Med. 349 (2): 139–45.

TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN manufacturers

Career Henan Chemical Co
Product
TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN 98474-59-0
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2020-03-05

98474-59-0, TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASNRelated Search:


  • H-TYR-GLY-SER-LEU-PRO-GLN-LYS-ALA-GLN-ARG-PRO-GLN-ASP-GLU-ASN-OH
  • H-TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN-OH
  • (DES-GLY77,DES-HIS78)-MYELIN BASIC PROTEIN (68-84) (BOVINE)
  • (DES-GLY77,DES-HIS78)-MYELIN BASIC PROTEIN (68-84) (GUINEA PIG)
  • DES-GLY77, DES-HIS78-MYELIN BASIC PROTEIN FRAGMENT 68-84 BOVINE
  • DES-[GLY77,HIS78] MYELIN BASIC PROTEIN (68-84), BOVINE
  • DES[GLY77,HIS78]-MYELIN BASIC PROTEIN, FRAGMENT 68-64
  • DES[GLY77, HIS78]-SER75,80-MYELIN BASIC PROTEIN BOVINE FRAGMENT 68-84
  • TYR-GLY-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN
  • TYR-GLY-SER-LEU-PRO-GLN-LYS-ALA-GLN-ARG-PRO-GLN-ASP-GLU-ASN
  • TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN
  • MYELIN BASIC PROTEIN, FRAGMENT 68-82
  • MYELIN BASIC PROTEIN FRAGMENT 68-82 GUINEA PIG
  • MYELIN BASIC PROTEIN (68-82), GUINEA PIG
  • des-gly77, des-his78-myelin basic protein bovine fragment 68-84
  • myelin basic protein guinea pig fragment 68-82
  • DES-GLY77, HIS78-MYELIN BASIC PROTEIN FRAGMENT 68-84 BOVINE
  • MYELIN BASIC PROTEIN MBP (68-82), GUINEA PIG
  • myelin, basic protein, fragment 68-84, des-Gly77, his78
  • des-Gly77
  • des-His78-Myelin Basic Protein Bovine fragment 68-84
  • (Des-Gly77,Des-His78)-Myelin Basic Protein (68-84) (guinea pig) (Des-Gly77,Des-His78)-MBP (68-84) (guinea pig)
  • (Des-Gly77,Des-His78)-MBP (68-84) (bovine)
  • (Des-Gly77,Des-His78)-MBP (68-84) (guinea pig)
  • L-Tyrosylglycyl-L-seryl-L-leucyl-L-prolyl-L-glutaminyl-L-lysyl-L-seryl-L-glutaminyl-L-arginyl-L-seryl-L-glutaminyl-L-alpha-aspartyl-L-alpha-glutamyl-L-asparagine
  • Myelin basic protein guinea pig fragment 68-82, ≥97% (HPLC)
  • (Des-Gly77,Des-His78)-Myelin Basic Protein (68-84) (guinea pig) H-Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn-OH
  • TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN USP/EP/BP
  • Myelin Basic Protein (MBP) (68-82), guinea pig,Inhibitor,inhibit,Myelin Basic Protein (MBP) (68 82), guinea pig,Myelin Basic Protein (MBP) (6882), guinea pig
  • MBP (68-82),Myelin Basic Protein (68-84), guinea pig
  • 98474-59-0
  • C73H115N23O26
  • Peptides
  • Other Neuropeptides
  • Miscellaneous Neuropeptides
  • Biochemicals and Reagents
  • BioChemical
  • Amino Acids and Peptides
  • Peptide
  • Neuroscience