1-PYRIMIDIN-2-YL-PIPERIDIN-4-ONE

Product Name: 1-PYRIMIDIN-2-YL-PIPERIDIN-4-ONE
CAS No.: 116247-92-8
Chemical Name: 1-PYRIMIDIN-2-YL-PIPERIDIN-4-ONE
Synonyms: 1-PYRIMIDIN-2-YL-PIPERIDIN-4-ONE;1-(2-pyrimidinyl)-2-piperidinone;4-Oxo-1-(pyrimidin-2-yl)piperidine;4-Piperidinone, 1-(2-pyrimidinyl)-;1-Pyrimidin-2-yl-piperidin-4-one95%;1-PYRIMIDIN-2-YL-PIPERIDIN-4-ONE 95%;1-(2-PYRIMIDINYL)TETRAHYDRO-4(1H)-PYRIDINONE;1-PYRIMIDIN-2-YL-PIPERIDIN-4-ONE ISO 9001：2015 REACH;4-Oxo-1-(pyrimidin-2-yl)piperidine, 2-(4-Oxopiperidin-1-yl)pyrimidine
CBNumber: CB8721350
Molecular Formula: C9H11N3O
Formula Weight: 177.2
MOL File: 116247-92-8.mol

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1-PYRIMIDIN-2-YL-PIPERIDIN-4-ONE Property

Melting point:: 73-75°C
Boiling point:: 366.8±52.0 °C(Predicted)
Density: 1.225±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, protect from light
pka: 4.65±0.33(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P997380
Product name: 1-Pyrimidin-2-yl-piperidin-4-one
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 044778
Product name: 1-(2-Pyrimidinyl)tetrahydro-4(1H)-pyridinone
Purity: >95%
Packaging: 500mg
Price: $26
Updated: 2021/12/16

Matrix Scientific

Product number: 044778
Product name: 1-(2-Pyrimidinyl)tetrahydro-4(1H)-pyridinone
Purity: >95%
Packaging: 1g
Price: $40
Updated: 2021/12/16

Apolloscientific

Product number: OR15509
Product name: 1-(Pyrimidin-2-yl)piperidin-4-one
Packaging: 1g
Price: $48
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-1-F3
Product name: 1-(Pyrimidin-2-yl)piperidin-4-one
Packaging: 1g
Price: $53
Updated: 2021/12/16

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1-PYRIMIDIN-2-YL-PIPERIDIN-4-ONE Chemical Properties,Usage,Production

Synthesis

1722-12-9

41979-39-9

116247-92-8

The general procedure for the synthesis of 1-(pyrimidin-2-yl)piperidin-4-one from 2-chloropyrimidine and 4-oxopiperidone hydrochloride is as follows: 5.1 Preparation of 1-(pyrimidin-2-yl)piperidin-4-one: A. A mixture of 4-piperidone monohydrate hydrochloride (4.84 g, 31.5 mmol), 2-chloropyrimidine (3.44 g, 30 mmol) and triethylamine (TEA, 10.04 mL, 72 mmol) was dissolved in ethanol (EtOH, 150 mL) and heated to reflux overnight. After completion of the reaction, the mixture was concentrated to near dryness and diluted with ethyl acetate (EtOAc, 400 mL). The EtOAc layer was washed sequentially with water (2 × 50 mL) and brine (2 × 50 mL). The aqueous layer was back-extracted with EtOAc (4 × 100 mL). All EtOAc layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and the solvent concentrated under reduced pressure. The residue was purified by ISCO fast chromatography (120 g silica gel column, elution procedure: hexane for 5 min, 0-80% EtOAc/hexane gradient for 70 min, and a final pure EtOAc elution for 15 min) to afford the target product 1-(pyrimidin-2-yl)piperidin-4-one (3.5 g, 66% yield). The product characterization data are shown below: HPLC analytical conditions: a Luna Phenyl-Hexyl 5 μm 4.6×50 mm column with 10 mM aqueous ammonium acetate as mobile phase A and acetonitrile as mobile phase B. Gradient elution (10-90% B, 3 min) was performed at a flow rate of 3 mL/min with retention times of 0.97 and 1.08 min. Mass spectrum (MS): m/z 178 [M+H]+. 1H NMR (300 MHz, CDCl3): δ 2.52 (t, J = 6.29 Hz, 4H), 4.15 (t, J = 6.20 Hz, 4H), 6.60 (t, J = 4.67 Hz, 1H), 8.38 (d, J = 4.77 Hz, 2H).

References

[1] Patent: WO2008/58064, 2008, A1. Location in patent: Page/Page column 17
[2] Patent: WO2008/58068, 2008, A1. Location in patent: Page/Page column 23
[3] Patent: WO2008/67120, 2008, A2. Location in patent: Page/Page column 23
[4] Patent: WO2008/67121, 2008, A2. Location in patent: Page/Page column 52
[5] Patent: US2006/258672, 2006, A1. Location in patent: Page/Page column 17

1-PYRIMIDIN-2-YL-PIPERIDIN-4-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-PYRIMIDIN-2-YL-PIPERIDIN-4-ONE manufacturers

Dideu Industries Group Limited

Product: 1-PYRIMIDIN-2-YL-PIPERIDIN-4-ONE 116247-92-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons
Release date: 2022-02-16

116247-92-8, 1-PYRIMIDIN-2-YL-PIPERIDIN-4-ONERelated Search:

1-PYRIMIDIN-2-YL-PIPERIDIN-4-ONE 1-(5-BROMOPYRIMIDIN-2-YL)-4-PIPERIDINONE 1-[4-(TRIFLUOROMETHYL)-2-PYRIMIDINYL]TETRAHYDRO-4(1H)-PYRIDINONE 2-PIPERIDINOPYRIMIDINE

1-(2-PYRIMIDINYL)TETRAHYDRO-4(1H)-PYRIDINONE

1-PYRIMIDIN-2-YL-PIPERIDIN-4-ONE

1-Pyrimidin-2-yl-piperidin-4-one95%

1-PYRIMIDIN-2-YL-PIPERIDIN-4-ONE 95%

4-Oxo-1-(pyrimidin-2-yl)piperidine, 2-(4-Oxopiperidin-1-yl)pyrimidine

4-Oxo-1-(pyrimidin-2-yl)piperidine

1-(2-pyrimidinyl)-2-piperidinone

4-Piperidinone, 1-(2-pyrimidinyl)-

1-PYRIMIDIN-2-YL-PIPERIDIN-4-ONE ISO 9001：2015 REACH

116247-92-8

API intermediates