Sodium Stearyl Fumarate

ChemicalBook > CAS DataBase List > Sodium Stearyl Fumarate

Sodium Stearyl Fumarate

Product Name: Sodium Stearyl Fumarate
CAS No.: 4070-80-8
Chemical Name: Sodium Stearyl Fumarate
Synonyms: Pruv;Sodium octadecyl;Sodium octadecyl fum;Sod. Stearyl fumarate;Sodium stearyl fumarat;Sodium steryl fumarate;SODIUM STEARYL FUMARATE;Sodium stearyi fumarate;SodiuM Srearyl FuMarate;Sitagliptin Impurity 93
CBNumber: CB8725343
Molecular Formula: C22H41NaO4
Formula Weight: 392.56
MOL File: 4070-80-8.mol

Less

Sodium Stearyl Fumarate Property

Melting point:: >196°C (dec.)
storage temp.: Inert atmosphere,Room Temperature
solubility: Practically insoluble in water, slightly soluble in methanol, practically insoluble in acetone and in anhydrous ethanol.
form: Solid
color: White to Off-White
InChIKey: GKCVIRALYIXVLE-RZLHGTIFSA-M
LogP: 8.789 (est)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2917191600

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1444
Product name: Sodium stearyl fumarate
Packaging: 1g
Price: $101
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1614705
Product name: Sodium stearyl fumarate
Packaging: 200mg
Price: $474
Updated: 2024/03/01

TCI Chemical

Product number: S0879
Product name: Sodium Stearyl Fumarate
Purity: >98.0%(T)
Packaging: 25g
Price: $71
Updated: 2024/03/01

TCI Chemical

Product number: S0879
Product name: Sodium Stearyl Fumarate
Purity: >98.0%(T)
Packaging: 100g
Price: $221
Updated: 2024/03/01

Sigma-Aldrich

Product number: S0808000
Product name: Sodium stearyl fumarate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: s0808000
Price: $220
Updated: 2024/03/01

Less

Sodium Stearyl Fumarate Chemical Properties,Usage,Production

Description

Sodium Stearyl Fumarate (SSF) is used as a lubricant in tableting to reduce the friction between the tablet and the die wall and to prevent adhesion of the material to punches or the die wall in the pharmaceutical industries. It is used also as a lubricant in the manufacturing of capsules and other oral dosage forms. Sodium stearyl fumarate is also used in food production as a dough conditioner, a conditioning agent, and a stabilizing agent.

Chemical Properties

White or off-white crystalline powder

Chemical Properties

Sodium stearyl fumarate is a fine, white powder with agglomerates of flat, circular-shaped particles.

Uses

Sodium Stearyl Fumarate is a dough conditioner and conditioning agent that is a white powder practically insoluble in water. It is used as a dough conditioner in yeast-raised baked goods. It is used as a conditioning agent in dehydrated potatoes. It also functions as a maturing and bleaching agent.

Production Methods

Stearyl alcohol is reacted with maleic anhydride. The product of this reaction then undergoes an isomerization step followed by salt formation to produce sodium stearyl fumarate.

General Description

Sodium Stearyl Fumarate is commonly used in tablet formulations as a lubricant and anti-adherent to improve powder flowability, reduce tablet sticking, and enhance the dissolution properties of the tablet.

Pharmaceutical Applications

Sodium stearyl fumarate is used as a lubricant in capsule and tablet formulations at 0.5–2.0% w/w concentration. It is also used in certain food applications.

Safety

Sodium stearyl fumarate is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material.
Metabolic studies of sodium stearyl fumarate in the rat and dog indicated that approximately 80% was absorbed and 35% was rapidly metabolized. The fraction absorbed was hydrolyzed to stearyl alcohol and fumaric acid, with the stearyl alcohol further oxidized to stearic acid. In the dog, sodium stearyl fumarate that was not absorbed was excreted unchanged in the feces within 24 hours.
Stearyl alcohol and stearic acid are naturally occurring constituents in various food products, while fumaric acid is a normal constituent of body tissue. Stearates and stearyl citrate have been reviewed by the WHO and an acceptable daily intake for stearyl citrate has been set at up to 50 mg/kg body-weight. The establishment of an acceptable daily intake for stearates and fumaric acid was thought unnecessary.
Disodium fumarate has been reported to have a toxicity not greatly exceeding that of sodium chloride.

storage

At ambient temperature, sodium stearyl fumarate is stable for up to 3 years when stored in amber glass bottles with polyethylene screw caps.
The bulk material should be stored in a well-closed container in a cool, dry place.

Incompatibilities

Sodium stearyl fumarate is reported to be incompatible with chlorhexidine acetate.

Regulatory Status

GRAS listed. Permitted by the FDA for direct addition to food for human consumption as a conditioning or stabilizing agent in various bakery products, flour-thickened foods, dehydrated potatoes, and processed cereals up to 0.2–1.0% by weight of the food. Included in nonparenteral medicines licensed in the UK. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

References

[1] Arne W. Hölzer and John Sjögren, Evaluation of sodium stearyl fumarate as a tablet lubricant, International Journal of Pharmaceutics, 1979, vol. 2, 145-153
[2] Holger Zorn and Peter Czermak, Biotechnology of Food and Feed Additives, 2014
[3] https://www.fda.gov

Sodium Stearyl Fumarate Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Sodium Stearyl Fumarate Suppliers

Australia 2 Austria 1 Belgium 1 Canada 2 China 234 Czech Republic 1 Europe 2 France 3 Germany 9 India 82 Japan 5 Singapore 1 Slovakia 1 South Korea 2 Spain 1 The Netherlands 1 Ukraine 1 United Kingdom 5 United States 28 Venezuela 1 Global 383

Chongqing Bioland Pharmaceuticat Ltd.

Tel: 023-68509220
Email: sales1@biolandpharm.com
Country: China
ProdList: 69
Advantage: 58

Hangzhou Read Chemical Co., Ltd

Tel: 15306818081 15306818081
Fax: 0571-87234255
Email: sales@hzread.com
Country: China
ProdList: 61
Advantage: 58

Shandong Huishengtang Biological Medicine Co., Ltd.

Tel: 0533-8082186 18853399702
Email: 1781022510@qq.com
Country: China
ProdList: 20
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44688
Advantage: 61

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18738
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2865
Advantage: 58

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Candia Thamtech Company Limited

Tel: 0371-86615086 18203638366 0371-86159066 13526786601
Fax: 0371-86159066
Country: China
ProdList: 2015
Advantage: 60

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

Wuhan DKY Technology Co.,Ltd.

Tel: 27-81302488 18007166089
Fax: 027-81302088
Email: info@dkybpc.com
Country: China
ProdList: 1734
Advantage: 58

Hubei XinyuanShun Chemical Co., Ltd.

Tel: 13971561712, 13995564702, 027-50664929
Fax: 027-50664927
Email: hbeixys2001@163.com
Country: China
ProdList: 3120
Advantage: 55

Huainan Kedi Chemical Factory

Tel: 0554-2106669
Fax: 0554-2666215
Email: sales1@kedichem.com
Country: China
ProdList: 4924
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18070
Advantage: 56

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4943
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 16166
Advantage: 55

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.

Tel: 027-59420981,18702770802
Fax: 027-83322098
Country: China
ProdList: 1975
Advantage: 50

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9958
Advantage: 58

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Watson Biotechnology Co.,Ltd

Tel: 027-59207879 1972026995 18140587686
Fax: QQ：1972026995
Email: sales@3600chem.com
Country: China
ProdList: 4660
Advantage: 55

Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6463
Advantage: 55

Hangzhou Dingyan Chem Co., LTD

Tel: 0571-87157530-8007 13868066926
Fax: 0571-87156470
Email: sales@dingyanchem.com
Country: China
ProdList: 2190
Advantage: 58

Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
ProdList: 5904
Advantage: 65

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27313
Advantage: 60

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20806
Advantage: 60

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

WG reagent

Tel: 13391486464
Fax: QQ:14748090
Email: samwjf@163.com
Country: China
ProdList: 3086
Advantage: 55

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973186 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 18338
Advantage: 68

Shenzhen Simeiquan Biotechnology Co. Ltd

Tel: 18126413629 0755-23311925 2355327053
Fax: 0755-23311925
Email: abel@ycgmp.com
Country: China
ProdList: 5113
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shenzhen Sendi Biological Technology Co., Ltd.

Tel: 18124570582 TEL：0755-23574479 2355327139
Fax: 0755-23229476 QQ: 2355327139
Email: siliao02@yccreate.com
Country: China
ProdList: 6116
Advantage: 58

Anhui kuer Bioengineering Co., Ltd

Tel: 0551-65171243 13856024262
Email: kuer@kuerhuaxue.com
Country: China
ProdList: 2997
Advantage: 55

Wuhan Magic Biological Technology Co., Ltd.

Tel: 18872289958、027-52304252、3400508168
Fax: 027-52304252
Email: 3400508168@qq.com
Country: China
ProdList: 1910
Advantage: 55

Guangzhou Kafen Biotech Co.,Ltd

Tel: 18029243487 2355327168
Fax: 020-31121510
Email: gy@yccreate.com
Country: China
ProdList: 4749
Advantage: 55

Wuhan Runzeweiye Technology Co., Ltd.

Tel: 15172337137 15172337137
Fax: 027-50779735
Email: 940329747@qq.com
Country: China
ProdList: 634
Advantage: 55

Wuhai Shuou Technology Co., Ltd.

Tel: 17792809151
Fax: 18872220797
Email: 2355916837@ycphar.com
Country: China
ProdList: 6133
Advantage: 55

Taian Jiaye Biotechnology Co.Ltd

Tel: 13127280945
Email: 285424065@qq.com
Country: China
ProdList: 9976
Advantage: 55

Less

View Lastest Price from Sodium Stearyl Fumarate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Sodium monooctadecyl 2-butenedioate, (E)- 4070-80-8
Price: US $70.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-05-28

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Sodium octadecyl fumarate 4070-80-8
Price: US $70.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-05-29

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Sodium Stearyl Fumarate 4070-80-8
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-06

4070-80-8, Sodium Stearyl FumarateRelated Search:

Sodium acetate Sodium bicarbonate Fumaric acid Dimethyl fumarate Quetiapine fumarate Ferrous fumarate Stearyl glycyrrhetinate Sodium stearate Monosodium fumarate Ketotifen fumarate Disodium fumarate Butyl stearate Potassium oleate Sodium oleate METHYL STEARATE Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Sitagliptin 2,4,5-TRIFLUOROBENZYL CHLORIDE

SODIUM STEARYL FUMARATE

sodium octadecyl fumarate

SodiumStearylFumarate(Excipient)OpenPartDmf

Sodium Stearyl Fumarate (Excipient)

Monosodium stearyl fumarate

2-Butenedioic acid (2E)-, monooctadecyl ester, sodium salt

SODIUMSTEARYLFUMARATE,FCC

SODIUMSTEARYLFUMARATE,NF

fumaric acid, monooctadecyl ester, sodium salt

SODIUMMONO-STEARYLFUMARATE

Sodium stearyl 2-fumarate

Sodium stearyi fumarate

sodiuM (E)-4-(octadecyloxy)-4-oxobut-2-enoate

SodiuM Stearyl FuMarate, 98.0%(T)

(E)-2-Butenedioic acid 1-octadecyl 4-sodium salt

Fumaric acid 1-octadecyl 4-sodium salt

Fumaric acid 1-stearyl 4-sodium salt

Pruv

SodiuM Srearyl FuMarate

Sodium Stearyl Fumarate (200 mg)

Fumaric Acid Stearyl Ester Sodium Salt Sodium Octadecyl Fumarate Fumaric Acid Octadecyl Ester Sodium Salt

(E)-2-Butenedioic acid monooctadecyl ester sodium salt

Sodium 2-octadecylfumarate

Sod. Stearyl fumarate

Sodium octadecyl

Sodium (2E)‐4‐(octadecyloxy)‐4‐oxobut‐2‐enoate

E-Sodium octadecyl fumarate

Sitagliptin Impurity 93

Sodium stearyl fumarat

Sodium Stearyl Fumarate &gt

Sodium stearyl fumarate CRS

Fumaric Acid Octadecyl Ester Sodium Salt

Fumaric Acid Stearyl Ester Sodium Salt

Sodium Stearyl Fumarate USP/EP/BP

Sodium 2-octadecylfumarate 4070-80-8

2-Butenedioic acid (2E)-, monooctadecyl ester, s

Sodium steryl fumarate

Sodium Stearyl Fumarate (pharmaceutical grade)

Sodium Stearyl Fumarate usp

Sodium Stearyl Fumarate (1614705)

Sodium stearate fumarate

Sodium Stearyl Fumarate, ≥ 98.0%

Sodium monooctadecyl 2-butenedioate, (E)-

Sodium octadecyl fum

Stearyl fumarate sodium in Methanol

4070-80-8

C22H39NaO4

C22H39O4Na

4070-80-8