Sodium Stearyl Fumarate

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Sodium Stearyl Fumarate

Product Name: Sodium Stearyl Fumarate
CAS No.: 4070-80-8
Chemical Name: Sodium Stearyl Fumarate
Synonyms: Pruv;Sodium octadecyl;Sod. Stearyl fumarate;Sodium stearyl fumarat;Sodium steryl fumarate;SODIUM STEARYL FUMARATE;Sodium stearyi fumarate;SodiuM Srearyl FuMarate;Sitagliptin Impurity 93;SODIUMSTEARYLFUMARATE,NF
CBNumber: CB8725343
Molecular Formula: C22H41NaO4
Formula Weight: 392.56
MOL File: 4070-80-8.mol

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Sodium Stearyl Fumarate Property

Melting point:: >196°C (dec.)
storage temp.: Inert atmosphere,Room Temperature
solubility: Practically insoluble in water, slightly soluble in methanol, practically insoluble in acetone and in anhydrous ethanol.
color: White to Off-White
InChIKey: GKCVIRALYIXVLE-RZLHGTIFSA-M
LogP: 8.789 (est)

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Safety

Hazard Codes: Xi
Risk Statements: 36/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2917191600

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1444
Product name: Sodium stearyl fumarate
Packaging: 1g
Price: $101
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1614705
Product name: Sodium stearyl fumarate
Packaging: 200mg
Price: $474
Updated: 2024/03/01

TCI Chemical

Product number: S0879
Product name: Sodium Stearyl Fumarate
Purity: >98.0%(T)
Packaging: 25g
Price: $71
Updated: 2024/03/01

TCI Chemical

Product number: S0879
Product name: Sodium Stearyl Fumarate
Purity: >98.0%(T)
Packaging: 100g
Price: $221
Updated: 2024/03/01

Sigma-Aldrich

Product number: S0808000
Product name: Sodium stearyl fumarate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: s0808000
Price: $220
Updated: 2024/03/01

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Sodium Stearyl Fumarate Chemical Properties,Usage,Production

Description

Sodium Stearyl Fumarate (SSF) is used as a lubricant in tableting to reduce the friction between the tablet and the die wall and to prevent adhesion of the material to punches or the die wall in the pharmaceutical industries. It is used also as a lubricant in the manufacturing of capsules and other oral dosage forms. Sodium stearyl fumarate is also used in food production as a dough conditioner, a conditioning agent, and a stabilizing agent.

Chemical Properties

Sodium stearyl fumarate is a fine, white powder with agglomerates of flat, circular-shaped particles.

Chemical Properties

White or off-white crystalline powder

Uses

Sodium Stearyl Fumarate is a dough conditioner and conditioning agent that is a white powder practically insoluble in water. It is used as a dough conditioner in yeast-raised baked goods. It is used as a conditioning agent in dehydrated potatoes. It also functions as a maturing and bleaching agent.

Uses

cationic transfection agent, bile acid sequestrant, vaccine adjuvant, protein stabilizer

Uses

Binder

Production Methods

Stearyl alcohol is reacted with maleic anhydride. The product of this reaction then undergoes an isomerization step followed by salt formation to produce sodium stearyl fumarate.

Pharmaceutical Applications

Sodium stearyl fumarate is used as a lubricant in capsule and tablet formulations at 0.5–2.0% w/w concentration. It is also used in certain food applications.

Safety

Sodium stearyl fumarate is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material.
Metabolic studies of sodium stearyl fumarate in the rat and dog indicated that approximately 80% was absorbed and 35% was rapidly metabolized. The fraction absorbed was hydrolyzed to stearyl alcohol and fumaric acid, with the stearyl alcohol further oxidized to stearic acid. In the dog, sodium stearyl fumarate that was not absorbed was excreted unchanged in the feces within 24 hours.
Stearyl alcohol and stearic acid are naturally occurring constituents in various food products, while fumaric acid is a normal constituent of body tissue. Stearates and stearyl citrate have been reviewed by the WHO and an acceptable daily intake for stearyl citrate has been set at up to 50 mg/kg body-weight. The establishment of an acceptable daily intake for stearates and fumaric acid was thought unnecessary.
Disodium fumarate has been reported to have a toxicity not greatly exceeding that of sodium chloride.

storage

At ambient temperature, sodium stearyl fumarate is stable for up to 3 years when stored in amber glass bottles with polyethylene screw caps.
The bulk material should be stored in a well-closed container in a cool, dry place.

Incompatibilities

Sodium stearyl fumarate is reported to be incompatible with chlorhexidine acetate.

Regulatory Status

GRAS listed. Permitted by the FDA for direct addition to food for human consumption as a conditioning or stabilizing agent in various bakery products, flour-thickened foods, dehydrated potatoes, and processed cereals up to 0.2–1.0% by weight of the food. Included in nonparenteral medicines licensed in the UK. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

References

[1] Arne W. Hölzer and John Sjögren, Evaluation of sodium stearyl fumarate as a tablet lubricant, International Journal of Pharmaceutics, 1979, vol. 2, 145-153
[2] Holger Zorn and Peter Czermak, Biotechnology of Food and Feed Additives, 2014
[3] https://www.fda.gov

Sodium Stearyl Fumarate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Sodium Stearyl Fumarate manufacturers

Hebei Shengyang Water Conservancy Engineering Co., Ltd.

Product: Sodium Stearyl Fumarate 4070-80-8
Price: US $18.00-18.00/kg
Min. Order: 1kg
Purity: 99.9
Supply Ability: 5000
Release date: 2024-05-08

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Sodium Stearyl Fumarate 4070-80-8
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-06

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Sodium Stearyl Fumarate 4070-80-8
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 200000kg
Release date: 2024-04-25

4070-80-8, Sodium Stearyl FumarateRelated Search:

Sodium acetate Sodium bicarbonate Fumaric acid Dimethyl fumarate Quetiapine fumarate Ferrous fumarate Stearyl glycyrrhetinate Sodium stearate Monosodium fumarate Ketotifen fumarate Disodium fumarate Butyl stearate Potassium oleate Sodium oleate METHYL STEARATE Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Sitagliptin 2,4,5-TRIFLUOROBENZYL CHLORIDE

SODIUM STEARYL FUMARATE

sodium octadecyl fumarate

SodiumStearylFumarate(Excipient)OpenPartDmf

Sodium Stearyl Fumarate (Excipient)

Monosodium stearyl fumarate

2-Butenedioic acid (2E)-, monooctadecyl ester, sodium salt

SODIUMSTEARYLFUMARATE,FCC

SODIUMSTEARYLFUMARATE,NF

fumaric acid, monooctadecyl ester, sodium salt

SODIUMMONO-STEARYLFUMARATE

Sodium stearyl 2-fumarate

Sodium stearyi fumarate

sodiuM (E)-4-(octadecyloxy)-4-oxobut-2-enoate

SodiuM Stearyl FuMarate, 98.0%(T)

(E)-2-Butenedioic acid 1-octadecyl 4-sodium salt

Fumaric acid 1-octadecyl 4-sodium salt

Fumaric acid 1-stearyl 4-sodium salt

Pruv

SodiuM Srearyl FuMarate

Sodium Stearyl Fumarate (200 mg)

Fumaric Acid Stearyl Ester Sodium Salt Sodium Octadecyl Fumarate Fumaric Acid Octadecyl Ester Sodium Salt

(E)-2-Butenedioic acid monooctadecyl ester sodium salt

Sodium 2-octadecylfumarate

Sod. Stearyl fumarate

Sodium octadecyl

Sodium (2E)‐4‐(octadecyloxy)‐4‐oxobut‐2‐enoate

E-Sodium octadecyl fumarate

Sitagliptin Impurity 93

Sodium stearyl fumarat

Sodium Stearyl Fumarate &gt

Sodium stearyl fumarate CRS

Fumaric Acid Octadecyl Ester Sodium Salt

Fumaric Acid Stearyl Ester Sodium Salt

Sodium Stearyl Fumarate USP/EP/BP

Sodium 2-octadecylfumarate 4070-80-8

2-Butenedioic acid (2E)-, monooctadecyl ester, s

Sodium steryl fumarate

Sodium Stearyl Fumarate (pharmaceutical grade)

Sodium Stearyl Fumarate usp

Sodium Stearyl Fumarate (1614705)

Sodium stearate fumarate

Sodium Stearyl Fumarate, ≥ 98.0%

4070-80-8

C22H39NaO4

C22H39O4Na

4070-80-8