FMOC-SER(AC)-OH

Product Name: FMOC-SER(AC)-OH
CAS No.: 171778-17-9
Chemical Name: FMOC-SER(AC)-OH
Synonyms: FMOC-SER(AC)-OH;FMOC-SERINE(AC)-OH;FMOC-O-ACETYL-L-SERINE;O-Acetyl-N-Fmoc-L-serine;Fmoc-O-acetyl-L-serine99%;N-ALPHA-FMOC-O-ACETYL-L-SERINE;(9H-Fluoren-9-yl)MethOxy]Carbonyl Ser(Ac)-OH;O-Acetyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serine;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-ACETYL-L-SERINE;L-Serine, O-acetyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
CBNumber: CB8732446
Molecular Formula: C20H19NO6
Formula Weight: 369.37
MOL File: 171778-17-9.mol

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FMOC-SER(AC)-OH Property

Boiling point:: 611.2±55.0 °C(Predicted)
Density: 1.322
storage temp.: Sealed in dry,Room Temperature
pka: 3.27±0.10(Predicted)
form: Solid
color: White to off-white
optical activity: -19.4°(C=0.01g/ml ETOH)
InChI: InChI=1S/C20H19NO6/c1-12(22)26-11-18(19(23)24)21-20(25)27-10-17-15-8-4-2-6-13(15)14-7-3-5-9-16(14)17/h2-9,17-18H,10-11H2,1H3,(H,21,25)(H,23,24)/t18-/m0/s1
InChIKey: HSGIKRPBGCJRDB-SFHVURJKSA-N
SMILES: C(O)(=O)[C@H](COC(C)=O)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F861043
Product name: Fmoc-Ser(Ac)-OH
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: F861043
Product name: Fmoc-Ser(Ac)-OH
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Usbiological

Product number: 238590
Product name: Fmoc-O-acetyl-L-serine 99+%
Packaging: 1g
Price: $222
Updated: 2021/12/16

Usbiological

Product number: 277042
Product name: Fmoc-O-acetyl-L-serine
Packaging: 500mg
Price: $333
Updated: 2021/12/16

Chem-Impex

Product number: 03771
Product name: Fmoc-O-acetyl-L-serine,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 25G
Price: $380.8
Updated: 2021/12/16

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FMOC-SER(AC)-OH Chemical Properties,Usage,Production

Uses

Fmoc-Ser(Ac)-OH (Fmoc-O-acetyl-L-serine) is a Serine derivative. Fmoc-Ser(Ac)-OH can be used for the preparation of broad-spectrum coronavirus membrane fusion inhibitor[1].

Synthesis

5147-00-2

82911-69-1

171778-17-9

General procedure for the synthesis of Fmoc-O-acetyl-L-serine from O-acetyl-L-serine and 9-fluorenylmethyl-N-succinimidyl carbonate: O-acetyl-L-serine (337 g, 1.0 mol) was dissolved in 10% aqueous sodium carbonate solution and stirred until completely dissolved. 9-Fluorenylmethyl-N-succinimidyl carbonate dissolved in ethyl acetate (340 to 3400 ml) was slowly added dropwise at 20-30°C for 30-60 minutes. After the dropwise addition was completed, the reaction was continued with stirring for 1-8 hours. After completion of the reaction, the excess 9-fluorenylmethyl-N-succinimidyl carbonate was separated and removed. The aqueous phase was acidified with hydrochloric acid to pH=1-2 and then extracted with ethyl acetate (30,000 ml). The organic phase was washed with water to remove residual hydrochloric acid and concentrated to give an oil. White crystals were precipitated from ethyl acetate by crystallization, filtered and dried to give 273.0 g of Nα-9-fluorenylmethoxycarbonyl-O-acetyl-L-serine in 74.0% overall yield. The product was 99.56% pure by HPLC, with a melting point of 161.5-162.2°C and specific optical rotation [α]D=-22.6 (c=1, DMF).

References

[1] Patent: CN107501127, 2017, A. Location in patent: Paragraph 0014; 0028; 0029; 0030

FMOC-SER(AC)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-SER(AC)-OH Suppliers

China 68 France 1 India 2 Japan 2 United States 10 Global 83

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View Lastest Price from FMOC-SER(AC)-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-Ser(Ac)-OH 171778-17-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99+
Supply Ability: 1T
Release date: 2024-03-06

171778-17-9, FMOC-SER(AC)-OHRelated Search:

FMOC-SER(AC)-OH FMOC-THR(AC)-OH O-ACETYL-L-SERINE Fmoc-L-Serine

N-ALPHA-FMOC-O-ACETYL-L-SERINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-ACETYL-L-SERINE

FMOC-O-ACETYL-L-SERINE

FMOC-SERINE(AC)-OH

FMOC-SER(AC)-OH

O-Acetyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serine

Fmoc-O-acetyl-L-serine99%

(9H-Fluoren-9-yl)MethOxy]Carbonyl Ser(Ac)-OH

(2S)-3-(acetyloxy)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-O-acetyl-L-serine

L-Serine, O-acetyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

(2S)-3-acetyloxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoicaci

O-Acetyl-N-Fmoc-L-serine

171778-17-9