N-NITROSODIETHYLAMINE Property

Melting point:

<25℃

Boiling point:

177 °C (lit.)

Density 

0.95 g/mL (lit.)

vapor pressure 

1.7 mmHg at 20 °C

refractive index 

n20/D 1.437

storage temp. 

2-8°C

solubility 

Chloroform (Soluble), Ethyl Acetate (Slightly), Methanol (Slightly)

pka

-3.14±0.70(Predicted)

form 

liquid

color 

yellow

Water Solubility 

106.2g/L(24 ºC)

Merck 

6636

BRN 

1744991

Stability:

Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents, reducing agents.

CAS DataBase Reference

55-18-5(CAS DataBase Reference)

IARC

2A (Vol. 17, Sup 7) 1987

EPA Substance Registry System

N-Nitrosodiethylamine (55-18-5)

Safety

Hazard Codes 

T,F

Risk Statements 

45-22-39/23/24/25-23/24/25-11

Safety Statements 

53-45-36/37-16

RIDADR 

UN 2810 6.1/PG 3

WGK Germany 

3

RTECS 

IA3500000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29299090

Hazardous Substances Data

55-18-5(Hazardous Substances Data)

Toxicity

LD50 oral (rat) 280 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H350May cause cancer

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

N-NITROSODIETHYLAMINE Chemical Properties,Usage,Production

Chemical Properties

N-Nitrosodiethylamine is a yellow liquid.

Uses

N,N-diethylnitrous Amide is a useful research reagent for organic synthesis.

Uses

N-Nitrosodiethylamine (DEN) is a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.

Uses

Gasoline and lubricant additive; antioxidant; stabilizer in plastics.

Definition

ChEBI: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.

General Description

Clear slightly yellow liquid. Boiling point 175-177°C. Can reasonably be anticipated to be a carcinogen. Used as a gasoline and lubricant additive and as an antioxidant and stabilizer in plastics.

Air & Water Reactions

Water soluble.

Reactivity Profile

N-NITROSODIETHYLAMINE reacts with strong oxidizing agents. Incompatible with reducing agents. Can be hydrolyzed by hydrogen bromide in acetic acid .

Hazard

Possible carcinogen; mutagen; neoplastigen; tumorigen; poison; teratogen.

Health Hazard

The acute toxicity of diethylnitrosamine is classified as moderate. Other nitrosamines of higher molecular weight are somewhat less toxic. Harmful exposure to nitrosamines can occur by inhalation and ingestion and may cause nausea, vomiting, and fever. This substance does not have adequate warning properties. Chronic exposure to nitrosamines can cause severe liver damage. Diethylnitrosamine is listed in IARC Group 2A ("probable human carcinogen") and is classified as an OSHA "select carcinogen." Nitrosamines are suspected of causing cancers of the lung, nasal sinuses, brain, esophagus, stomach, liver, bladder, and kidney. Diethylnitrosamine is mutagenic and teratogenic.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition N-NITROSODIETHYLAMINE emits toxic fumes of nitrogen oxides.

Fire Hazard

N-NITROSODIETHYLAMINE is combustible.

Fire Hazard

Volatilization during combustion produces hazardous vapors. Combustion products contain nitrogen oxides.

Flammability and Explosibility

Volatilization during combustion produces hazardous vapors. Combustion products contain nitrogen oxides.

Biochem/physiol Actions

N-Nitrosodiethylamine (NDMA) is carcinogenic in all animal species tested. The main target organs are the nasal cavity, trachea, lung, esophagus and liver. NDMA is acted upon by the cytochrome P450 system resulting in the formation of carcinogenic methyldiazonium ion. However microbes like Pseudomonas metabolize NDMA into N-nitromethylamine (NTMA) and formaldehyde.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A transplacental carcinogen. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS and AMINES.

Potential Exposure

An additive in gasoline and lubricants; an antioxidant and stabilizer in plastics. Used in research. Incompatibilities: Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact with reducing agents may form hydrazine; hydrogen bromide. Light sensitive; rapidly decomposes.

Carcinogenicity

N-Nitrosodiethylamine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

storage

work with diethylnitrosamine should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and splash goggles should be worn at all times to prevent skin and eye contact.

Shipping

UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Incompatibilities

An additive in gasoline and lubricants; an antioxidant and stabilizer in plastics. Used in research. Incompatibilities: Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact with reducing agents may form hydrazine; hydrogen bromide. Light sensitive; rapidly decomposes.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Under 40 CFR 261.5 small quantity generators of this waste may qualify for partial exclusion from hazardous waste regulations.