ChemicalBook > CAS DataBase List > (5-BUTANOATE-1H-2-INDOLYL)(1H-2-INDOLYL)-METHANONE

(5-BUTANOATE-1H-2-INDOLYL)(1H-2-INDOLYL)-METHANONE

Product Name
(5-BUTANOATE-1H-2-INDOLYL)(1H-2-INDOLYL)-METHANONE
CAS No.
249762-74-1
Chemical Name
(5-BUTANOATE-1H-2-INDOLYL)(1H-2-INDOLYL)-METHANONE
Synonyms
D-65476;PDGFR Tyrosine Kinase Inhibitor II;PDGF RECEPTOR TYROSINE KINASE INHIBITOR II;[2-(1H-2-INDOLYCARBONYL)-1H-5-INDOLYL]BUTANOATE;[2-(1H-2-INDOLYLCARBONYL)-1H-5-INDOLYL]BUTANOATE;(5-BUTANOATE-1H-2-INDOLYL)(1H-2-INDOLYL)-METHANONE;Butanoic acid, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl ester
CBNumber
CB8739506
Molecular Formula
C21H18N2O3
Formula Weight
346.38
MOL File
Mol file
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(5-BUTANOATE-1H-2-INDOLYL)(1H-2-INDOLYL)-METHANONE Property

storage temp. 
2-8°C
solubility 
DMSO: 5mg/mL
form 
solid
color 
yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
521231
Product name
PDGFR Tyrosine Kinase Inhibitor II - CAS 249762-74-1 - Calbiochem
Packaging
1mg
Price
$278
Updated
2025/07/31
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(5-BUTANOATE-1H-2-INDOLYL)(1H-2-INDOLYL)-METHANONE Chemical Properties,Usage,Production

Uses

D-65476 is an inhibitor of type Ⅲ receptor tyrosine kinase (Flt3). In the absence of IL-3, D-65476 inhibits the proliferation of TEL-Flt3 transfected BA/F3 cells (IC50= 0.2 μM), which can be used in the study of Flt3-driven leukemia[1].

Biological Activity

Cell permeable: yes', 'Primary Target
PDGFR in swiss 3T3 cells', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 1.1 μM inhibiting PDGFR in swiss 3T3 cells; 6.2 μ M for hPDGFβ-R-mFlt3 and 50 nM in EOL-1 cells

References

[1] Teller S, et al. Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3. Leukemia. 2002;16(8):1528-1534. DOI:10.1038/sj.leu.2402630

(5-BUTANOATE-1H-2-INDOLYL)(1H-2-INDOLYL)-METHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(5-BUTANOATE-1H-2-INDOLYL)(1H-2-INDOLYL)-METHANONE Suppliers

China 4 United States 1 Global 5
SynAsst Chemical.
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021-60343070
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021-35122006
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China
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12740
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Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
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China
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6394
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Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
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6594
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249762-74-1, (5-BUTANOATE-1H-2-INDOLYL)(1H-2-INDOLYL)-METHANONERelated Search:


  • PDGF RECEPTOR TYROSINE KINASE INHIBITOR II
  • PDGFR Tyrosine Kinase Inhibitor II
  • D-65476
  • [2-(1H-2-INDOLYCARBONYL)-1H-5-INDOLYL]BUTANOATE
  • [2-(1H-2-INDOLYLCARBONYL)-1H-5-INDOLYL]BUTANOATE
  • (5-BUTANOATE-1H-2-INDOLYL)(1H-2-INDOLYL)-METHANONE
  • Butanoic acid, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl ester
  • 249762-74-1