FURA-FF, AM
- Product Name
- FURA-FF, AM
- CAS No.
- 348079-12-9
- Chemical Name
- FURA-FF, AM
- Synonyms
- FURA-FF, AM;Fura-FF, AM [Fura-2FF, AM] *CAS 348079-12-9*;5-Oxazolecarboxylic acid, 2-[6-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-[2-[6-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-2,3-difluorophenoxy]ethoxy]-2-benzofuranyl]-, (acetyloxy)methyl ester
- CBNumber
- CB8741336
- Molecular Formula
- C43H43F2N3O24
- Formula Weight
- 1023.8
- MOL File
- 348079-12-9.mol
FURA-FF, AM Property
- Boiling point:
- 971.5±75.0 °C(Predicted)
- Density
- 1.447±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble
- form
- A solid
- pka
- 0.36±0.50(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- 20416
- Product name
- Fura-FF AM
- Purity
- ≥90%
- Packaging
- 50μg
- Price
- $63
- Updated
- 2024/03/01
FURA-FF, AM Chemical Properties,Usage,Production
Description
Fura-FF AM is a cell-permeable acetoxymethyl ester of the fluorescence calcium indicator fura-FF (potassium salt) . As fura-FF AM enters cells, it is hydrolyzed by intracellular esterases to produce fura-FF. Fura-FF is a difluorinated derivative of the calcium indicator fura-2 . Unlike, fura-2, fura-FF has negligible magnesium sensitivity, thus reducing interference from this cation.1 Fura-FF also has a higher calcium dissociation constant than fura-2 (Kd(calcium) = 6 and 0.14 μM, respectively).1,2 However, the spectral properties of fura-FF and fura-2 are similar with fura-FF displaying excitation/emission spectra of 365/514 nm in the absence of calcium, with a shift to 339/507 nm in the presence of a high calcium concentration.3 Low affinity calcium dyes, including fura-FF, are preferred for studying compartments with high concentrations of calcium, such as mitochondria, or in cell systems that have relatively low calcium buffering capacities, such as neuronal dendrites and spines.4,5,6
References
1. Hyrc, K.L., Bownik, J.M., and Goldberg, M.P. Ionic selectivity of low-
2. Grynkiewicz, G., Poenie, M., and Tsien, R.Y. A new generation of Ca2+ indicators with greatly improved fluorescence properties J. Biol. Chem. 260(6),3440-3450(1985).
3. Ruggiu, A.A., Bannwarth, M., and Johnsson, K. Fura-
4. Aponte, Y., Bischofberger, J., and Jonas, P. Efficient Ca2+ buffering in fast-
5. Canepari, M., Vogt, K., and Zecevic, D. Combining voltage and calcium imaging from neuronal dendrites Cell. Mol. Neurobiol. 28(8),1079-1093(2008).
6. Marcu, R., Neely, C.K., Karamanlidis, G., et al. Multi-
FURA-FF, AM Preparation Products And Raw materials
Raw materials
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