BPIQ-I

Product Name: BPIQ-I
CAS No.: 174709-30-9
Chemical Name: BPIQ-I
Synonyms: BPIQ-I;N-(3-bromophenyl)-3-methylimidazo[4,5-g]quinazolin-8-amine;8-[(3-BROMOPHENYL)AMINO]-3-METHYL-3H-IMIDAZO[4,5-G]-QUINAZOLINE;3H-Imidazo[4,5-g]quinazolin-8-amine, N-(3-bromophenyl)-3-methyl-;8-[(3-BROMOPHENYL)AMINO]-3-METHYL-3H-IMIDAZO[4,5-GAMMA]-QUINAZOLINE
CBNumber: CB8749574
Molecular Formula: C16H12BrN5
Formula Weight: 354.2
MOL File: Mol file

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BPIQ-I Property

Boiling point:: 535.5±60.0 °C(Predicted)
Density: 1.62±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 20 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form: A crystalline solid
pka: 5.12±0.50(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17224
Product name: BPIQ-I
Purity: ≥95%
Packaging: 500μg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 17224
Product name: BPIQ-I
Purity: ≥95%
Packaging: 1mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 17224
Product name: BPIQ-I
Purity: ≥95%
Packaging: 5mg
Price: $638
Updated: 2024/03/01

AK Scientific

Product number: 0286CA
Product name: Bpiq-i
Packaging: 5mg
Price: $808
Updated: 2021/12/16

AK Scientific

Product number: 0286CA
Product name: Bpiq-i
Packaging: 1mg
Price: $282
Updated: 2021/12/16

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BPIQ-I Chemical Properties,Usage,Production

Description

BPIQ-I is a quinazoline that inhibits the tyrosine kinase activity of the epidermal growth factor receptor (IC₅₀ = 0.025 nM). It can inhibit the growth of SKOV3 and MDA-468 tumor cell lines with EC₅₀ values of 6.5 and 30 μM, respectively.

Uses

BPIQ-I (PD 159121) is a potent and ATP-competitive EGFR tyrosine kinase inhibitor.. BPIQ-I shows anti-proliferative actively[1][2].

References

[1] Rae JM, et al. Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors. Breast Cancer Res Treat. 2004 Jan;83(2):99-107. DOI:10.1023/B:BREA.0000010702.10130.29
[2] Zhou Y, et al. Role of a tyrosine kinase in the CO2-induced stimulation of HCO3- reabsorption by rabbit S2 proximal tubules. Am J Physiol Renal Physiol. 2006 Aug;291(2):F358-67. DOI:10.1152/ajprenal.00520.2005

BPIQ-I Preparation Products And Raw materials

Raw materials

Preparation Products

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BPIQ-I Suppliers

China 28 Switzerland 1 United Kingdom 1 United States 4 Global 34

BOC Sciences

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BOC Sciences

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Shanghai Hongye Biotechnology Co. Ltd

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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ShangHai ChuanQian Chemcial Technique Centre

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MedBioPharmaceutical Technology Inc

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Nantong QuanYi Biotechnology Co., Ltd

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Shanghai Yifei Biotechnology Co. , Ltd.

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Cayman Chemical Company

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Santa Cruz Biotechnology Inc

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174709-30-9, BPIQ-IRelated Search:

8-[(3-BROMOPHENYL)AMINO]-3-METHYL-3H-IMIDAZO[4,5-GAMMA]-QUINAZOLINE

8-[(3-BROMOPHENYL)AMINO]-3-METHYL-3H-IMIDAZO[4,5-G]-QUINAZOLINE

BPIQ-I

N-(3-bromophenyl)-3-methylimidazo[4,5-g]quinazolin-8-amine

3H-Imidazo[4,5-g]quinazolin-8-amine, N-(3-bromophenyl)-3-methyl-

174709-30-9