ChemicalBook > CAS DataBase List > 1-Benzyl-3-pyrrolidinone

1-Benzyl-3-pyrrolidinone

Product Name: 1-Benzyl-3-pyrrolidinone
CAS No.: 775-16-6
Chemical Name: 1-Benzyl-3-pyrrolidinone
Synonyms: 1-BENZYLPYRROLIDIN-3-ONE;1-Benzylpyrrolidinone;N-BENZYL-3-PYRROLIDONE;1-BENZYL-3-PYRROLIDONE;1-BENZLY-3-PYRROLIDONE;5 N-Benzyl-3-Pyrrolidone;N-BeNzyl-3-pyrrolidiNoNe;1-BENZYL-3-PYRROLIDINONE;1-Benzyl-3-pyrrolizinone;1-Benzylpyrrolizin-3-one
CBNumber: CB8753449
Molecular Formula: C11H13NO
Formula Weight: 175.23
MOL File: 775-16-6.mol

Less

1-Benzyl-3-pyrrolidinone Property

Boiling point:: 77 °C/0.01 mmHg (lit.)
Density: 1.091 g/mL at 25 °C (lit.)
refractive index: n20/D 1.539(lit.)
Flash point:: >230 °F
storage temp.: 2-8°C
form: Crystalline Powder, Crystals or Chunks
pka: 5.56±0.20(Predicted)
color: White to off-white
BRN: 1526217
InChI: InChI=1S/C11H13NO/c13-11-6-7-12(9-11)8-10-4-2-1-3-5-10/h1-5H,6-9H2
InChIKey: DHGMDHQNUNRMIN-UHFFFAOYSA-N
SMILES: N1(CC2=CC=CC=C2)CCC(=O)C1
CAS DataBase Reference: 775-16-6(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-37/39-24/25-36
WGK Germany: 3
F: 10
HazardClass: IRRITANT, KEEP COLD
HS Code: 29339900

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B3606
Product name: 1-Benzyl-3-pyrrolidone
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $128
Updated: 2023/01/07

TCI Chemical

Product number: B3606
Product name: 1-Benzyl-3-pyrrolidone
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $365
Updated: 2025/07/31

TRC

Product number: B288760
Product name: 1-Benzyl-3-pyrrolidinone
Packaging: 10g
Price: $140
Updated: 2021/12/16

TRC

Product number: B288760
Product name: 1-Benzyl-3-pyrrolidinone
Packaging: 100g
Price: $1100
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0034802
Product name: 1-BENZYL-3-PYRROLIDINONE
Purity: 95.00%
Packaging: 1G
Price: $648.81
Updated: 2021/12/16

Less

1-Benzyl-3-pyrrolidinone Chemical Properties,Usage,Production

Chemical Properties

clear yellow liquid

Uses

Substrate used to prepare chiral, alkenyl sulfoximines leading to highly functionalized diazabicycles.1

Uses

1-Benzyl-3-pyrrolidinone is a substrate used to prepare chiral, alkenyl sulfoximines leading to highly functionalized diazabicycles.

Uses

1-Benzyl-3-pyrrolidinone was used as starting reagent in the synthesis of vinyl triflate. It was used to prepare chiral, alkenyl sulfoximines leading to highly functionalized diazabicycles.

General Description

The equilibrium constant for the ketoreductase-catalyzed reduction reaction of 1-benzyl-3-pyrrolidinone has been measured in n-hexane. 1-Benzyl-3-pyrrolidinone on enzymatic asymmetric reduction yields enantiopure 1-benzyl-3-hydroxypyrrolidine, well known intermediate for various drugs.

Synthesis

775-15-5

775-16-6

General procedure for the synthesis of 1-benzyl-3-pyrrolidinone from N-benzyl-3-hydroxypyrrolidine: 12.50 g of oxalyl chloride was slowly added dropwise to 70 mL of dichloromethane, stirred and cooled to -65 °C or lower. Subsequently, a dichloromethane solution of 5.0 g of DMSO was added dropwise, keeping the reaction temperature at -65°C. After dropwise addition, stirring was continued for 30 minutes. Next, 8.80 g of a dichloromethane solution of 1-benzyl-3-hydroxypyrrolidine was added dropwise, maintaining the temperature at -65 °C, and the reaction progress was monitored by TLC. After 2 hours of reaction, triethylamine was slowly added dropwise at -65 °C, controlling the temperature at -65 °C, and stirring was continued for 30 minutes after completion of the dropwise addition. Subsequently, the temperature of the reaction system was raised to 0 °C and water was added dropwise to transform the suspension into a clarified solution. The organic layer was separated, washed with brine and dried to give 8.00 g of 1-benzyl-3-pyrrolidone in 90.90% yield and 95% HPLC purity.

References

[1] Patent: CN106938980, 2017, A. Location in patent: Paragraph 0026-0031
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 9, p. 2465 - 2469

1-Benzyl-3-pyrrolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

Less

1-Benzyl-3-pyrrolidinone Suppliers

Americas 1 Belgium 4 Canada 1 China 259 Europe 2 France 1 Germany 6 India 22 Japan 4 Slovakia 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 13 United States 44 Global 362

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-69209928 18796809688
Fax: 0512-68417696
Email: zhouyingxiang@highfine.com
Country: China
ProdList: 475
Advantage: 75

Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 028-87078428 028-87074958
Fax: 8772-8116
Email: chengzhenyong@cdfirster.com
Country: China
ProdList: 2598
Advantage: 60

Dalian Ruiying Technology Co., Ltd.

Tel: 0411-86907150 15940963210
Email: 609262758@qq.com
Country: China
ProdList: 893
Advantage: 58

Anhui Dexinjia Biopharm Co., Ltd

Tel: 0531-82375892 15553111391
Email: 3276840968@qq.com
Country: China
ProdList: 301
Advantage: 58

Shanghai Hobor Chemical Co., Ltd

Tel: 021-57790084; 13918007836
Fax: 021-51685238
Email: sales@hoborchem.com
Country: China
ProdList: 392
Advantage: 60

Suzhou Uugene Biopharma Co., Ltd.

Tel: 0512-69561956 18015581618
Email: sales@uugene.com
Country: China
ProdList: 101
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

PharmaBlock Sciences (Nanjing),Inc.

Tel: 025-86918202 4000255188
Fax: 86-025-86918232
Email: sales@pharmablock.com
Country: China
ProdList: 5000
Advantage: 55

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Sichuan Guanghan Bio-Tech Co., Ltd

Tel: +86-28-86127071
Fax: +86-28-86127072
Email: info@sino-produce.com
Country: China
ProdList: 406
Advantage: 66

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Chembon Pharmaceutical Co., Ltd.

Tel: 028-84252981
Fax: +86-28-84252965
Email: sales@chembon.com.cn
Country: China
ProdList: 850
Advantage: 64

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Nanjing Vital Chemical Co., Ltd.

Tel: Please Send Email 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 4378
Advantage: 65

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Suzhou Sibian Chemical Technology Co.,Ltd.

Tel: 0512-65617459 18915409046
Fax: 0512-65617459
Email: sales@sibian-chem.com
Country: China
ProdList: 1922
Advantage: 55

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6134
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

SuZhou ShiYa Biopharmaceuticals, Inc.

Tel: 86(512)5235 8471 17715136450
Fax: 86(512)5235 6881
Email: sales@shiyabiopharm.com
Country: China
ProdList: 4169
Advantage: 58

Candia Thamtech Company Limited

Tel: 0371-86615086 18203638366 0371-86159066 13526786601
Fax: 0371-86159066
Country: China
ProdList: 2015
Advantage: 60

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8026
Advantage: 55

Wuxi Zhangkun Biochemical Technology Co., Ltd.

Tel: +86 0510-85629785
Fax: +86 0510-85625359
Country: China
ProdList: 2327
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
Advantage: 55

Beijing Universal Century Technology Co., Ltd.

Tel: 400-8706899
Fax: 400-8706899
Email: hysj_bj.com
Country: China
ProdList: 3583
Advantage: 55

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Megchem Co., Ltd.

Tel: +86 (21) 5471-7132
Fax: +86 (21) 5471-6993
Country: China
ProdList: 344
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Zhengzhou HongSheng Pharmaceutical Co., Ltd.

Tel: 0371-0371-13526885213 15637198702
Fax: 0371-63709726
Email: hsyykjchem@163.com
Country: China
ProdList: 3853
Advantage: 58

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Credit-Chem Co., Ltd.

Tel: 400-821-5857 021-64326257
Fax: 021-64393586 QQ;2798200800
Email: credit-chem@foxmail.com
Country: China
ProdList: 5219
Advantage: 58

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4942
Advantage: 58

Less

View Lastest Price from 1-Benzyl-3-pyrrolidinone manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-Benzyl-3-pyrrolidinone 775-16-6
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50kg
Release date: 2025-06-24

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 1-Benzyl-3-pyrrolidinone 775-16-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-22

Henan Aochuang Chemical Co.,Ltd.

Product: 1-Benzyl-3-pyrrolidinone 775-16-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

775-16-6, 1-Benzyl-3-pyrrolidinoneRelated Search:

N-Methyl-2-pyrrolidone Benzyl acetate N-Vinyl-2-pyrrolidone Benzoyl peroxide Benzyl chloride Povidone iodine Polyvinylpyrrolidone 2-Pyrrolidinone 3-Pyrrolidinone Benzyl butyrate Benzyl alcohol Benzyl benzoate Benzyl METHYL-2-PYRROLIDONE 1-BENZYL-4-PYRROLIDINONE,1-BENZYL-2-PYRROLIDINONE 99%,N-BENZYL-2-PYRROLIDINONE,1-BENZYL-2-PYRROLIDINONE 1-Benzyl-3-piperidinol hydrochloride ALPHA-PYRIDOIN 1-Benzyl-2-methyl-3-pyrrolidone

1-BENZYL-3-PYRROLIDINONE

1-BENZYL-3-PYRROLIDONE

1-BENZYLPYRROLIDIN-3-ONE

N-BENZYL-3-PYRROLIDONE

1-(PHENYLMETHYL)-3-PYRROLIDINONE

N-BeNzyl-3-pyrrolidiNoNe

5 N-Benzyl-3-Pyrrolidone

1-BENZLY-3-PYRROLIDONE

1-Benzylpyrrolidinone

N-BENZYL-3-PYRROLIDINONE (30%)

N-BENZYL-3-PYRROLIDINONE 30%

1-Benzyl-pyrrolidin-3-oneHCl

1-(Phenylmethyl)pyrrolidin-3-one

3-Pyrrolidinone, 1-(phenylmethyl)-

1-BENZYL-3-PYROLLIDONE-HCL

1-Benzyl-3-pyrrolizinone

1-Benzylpyrrolizin-3-one

1-Phenylmethyl-3-pyrrolizinone

1-(Phenylmethyl)-3-pyrrolidinone,98%

1-Benzyl-3-pyrrolidinone ,97%

1-(PhenylMethyl)-3-pyrrolidinone, 98% 1GR

1-N benzyl-3-pyrrolidinone

1-Benzyl-3-oxopyrrolidine, [(3-Oxopyrrolidin-1-yl)methyl]benzene

1-Benzyl-3-pyrrolidinone,98%

1-Benzyl-3-pyrrolidone≥ 98%(GC)

1-Benzyl-3-pyrrolidinone 98%

1-Benzyl-3-pyrrolidone&gt

1-Benzyl-3-pyrrolidinone ISO 9001：2015 REACH

775-16-6 C11H13NO 1-Benzyl-3-pyrrolidinone

1-Benzyl-3-pyrrolidinone, 96%

775-16-6

755-16-6

Pyrrolidines

Heterocyclic Building Blocks

KETONE

Building Blocks

C11 to C12

Chemical Synthesis

Heterocyclic Building Blocks

Pharmaceutical Intermediates

Pyrrole&Pyrrolidine&Pyrroline

Building Blocks

Heterocyclic Building Blocks

Pyrrolidines

Amines and Anilines

Carbonyl Compounds