ChemicalBook > CAS DataBase List > Methyl coumalate

Methyl coumalate

Product Name
Methyl coumalate
CAS No.
6018-41-3
Chemical Name
Methyl coumalate
Synonyms
METHYL 2-OXO-2H-PYRAN-5-CARBOXYLATE;Coumalic acid methyl ester;Methyl coumaric acid;METHYL COUMALATE;TIMTEC-BB SBB000117;Methyl coumalate 98%;Methyl Coumalate >5-(Carbomethoxy)-2-pyrone;Methyl 2-pyrone-5-carboxylate;METHYL PYR-2-ONE-5-CARBOXYLATE
CBNumber
CB8755382
Molecular Formula
C7H6O4
Formula Weight
154.12
MOL File
6018-41-3.mol
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Methyl coumalate Property

Melting point:
65-67 °C (lit.)
Boiling point:
178-180 °C/60 mmHg (lit.)
Density 
1.1993 (rough estimate)
refractive index 
1.4300 (estimate)
Flash point:
178-180°C/60mm
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Freely soluble in dichloromethane.
form 
powder to crystal
color 
White to Orange to Green
Merck 
14,2557
BRN 
126301
LogP
-0.660 (est)
CAS DataBase Reference
6018-41-3(CAS DataBase Reference)
NIST Chemistry Reference
2H-Pyran-5-carboxylic acid, 2-oxo-, methyl ester(6018-41-3)
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Safety

WGK Germany 
3
HS Code 
2932209090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
261432
Product name
Methyl coumalate
Purity
98%
Packaging
10g
Price
$441
Updated
2024/03/01
TCI Chemical
Product number
C1734
Product name
Methyl Coumalate
Purity
>96.0%(GC)
Packaging
5g
Price
$85
Updated
2024/03/01
TCI Chemical
Product number
C1734
Product name
Methyl Coumalate
Purity
>96.0%(GC)
Packaging
25g
Price
$278
Updated
2024/03/01
Alfa Aesar
Product number
B25330
Product name
Methyl coumalate, 98%
Packaging
2g
Price
$47.65
Updated
2024/03/01
Alfa Aesar
Product number
B25330
Product name
Methyl coumalate, 98%
Packaging
10g
Price
$165.65
Updated
2024/03/01
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Methyl coumalate Chemical Properties,Usage,Production

Uses

α, β-Unsaturated ketone Methyl Coumalate showed cytotoxicity against human normal gingival fibroblast cells and oral squamous cell carcinoma cell line-2.

Uses

Methyl coumalate is a 2-pyrone and acts as dienophile in Diels-Alder reaction. It reacts with 1,3-butadienes at 100°C to yield tetrahydrocoumarins and 4-methoxycarbonyltricyclo[3.2.1.02,7]octenes. It also reacts with cyclohexadiene to afford tetrahydronaphthalene-2-carboxylate. It undergoes Diels-Alder reaction with unactivated alkenes to afford para-substituted adducts. It has been used as reagent in phosphine-catalyzed [4+3] annulation of modified allylic carbonates. It was also used in the preparation of 7-carboxyquinolizinium derivatives.

Uses

Methyl coumalate has been used as reagent in phosphine-catalyzed [4+3] annulation of modified allylic carbonates. It was also used in the preparation of 7-carboxyquinolizinium derivatives.

General Description

Methyl coumalate is a 2-pyrone and acts as dienophile in Diels-Alder reaction. It reacts with 1,3-butadienes at 100°C to yield tetrahydrocoumarins and 4-methoxycarbonyltricyclo[3.2.1.02,7]octenes. It also reacts with cyclohexadiene to afford tetrahydronaphthalene-2-carboxylate. It undergoes Diels-Alder reaction with unactivated alkenes to afford para-substituted adducts.

Methyl coumalate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl coumalate manufacturers

Guangzhou Sunton Biotechnology Co., Ltd.
Product
Methyl coumaric acid 6018-41-3
Price
US $48.00-40.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200tons
Release date
2021-06-09
Shaanxi Dideu Medichem Co. Ltd
Product
methyl 2-oxo-2H-pyran-5-carboxylate 6018-41-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-01-03
Zhuozhou Wenxi import and Export Co., Ltd
Product
Methyl coumalate 6018-41-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

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