2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

Product Name: 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
CAS No.: 885278-75-1
Chemical Name: 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
Synonyms: Ethyl 2-(4-bromophenyl)thiazole-4-carboxylate;Ethyl 2-(4-bromophenyl)-1,3-thiazole-4-carboxylate;4-THIAZOLECARBOXYLICACID, 2-(4-BROMOPHENYL)-, ETHYL ESTER;2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
CBNumber: CB8755544
Molecular Formula: C12H10BrNO2S
Formula Weight: 312.18
MOL File: 885278-75-1.mol

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2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Property

Melting point:: 89-91 °C
Boiling point:: 404.6±51.0 °C(Predicted)
Density: 1.500±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -0.42±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B698715
Product name: 2-(4-Bromo-phenyl)-thiazole-4-carboxylicacidethylester
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B698715
Product name: 2-(4-Bromo-phenyl)-thiazole-4-carboxylicacidethylester
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: B698715
Product name: 2-(4-Bromo-phenyl)-thiazole-4-carboxylicacidethylester
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB56451
Product name: 2-(4-Bromophenyl)thiazole-4-carboxylic acid ethyl ester
Packaging: 250mg
Price: $85
Updated: 2021/12/16

AK Scientific

Product number: W9103
Product name: Ethyl2-(4-bromophenyl)thiazole-4-carboxylate
Packaging: 5g
Price: $181
Updated: 2021/12/16

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2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

70-23-5

26197-93-3

885278-75-1

The general procedure for the synthesis of ethyl 2-(4-bromophenyl)-thiazole-4-carboxylate from ethyl 3-bromopyruvate and 4-bromothiobenzamide is as follows: (i) Ethyl 3-bromopyruvate (0.18 mL, 1.0 mmol) was slowly added to an ethanol solution (3 mL) of 4-bromothiobenzamide (529 mg, 1.0 mmol). (ii) The reaction mixture was stirred at room temperature for 6 h. The precipitated crystals were subsequently collected by filtration and dried. (iii) The dried crystals were slowly added dropwise to concentrated sulfuric acid (5 mL) and stirred at room temperature for 3 hours. (iv) The solvent was removed by distillation and the residue was diluted with ethyl acetate. (v) The diluted solution was washed sequentially with saturated aqueous sodium bicarbonate and deionized water, and the organic layer was dried with anhydrous magnesium sulfate. (vi) After filtration, the filtrate was concentrated and the resulting crystals were collected by filtration and dried to afford ethyl 2-(4-bromophenyl)-thiazole-4-carboxylate (285 mg, 91% yield). Product characterization data: 1H-NMR (300 MHz, CDCl3) δ: 1.30 (3H, t, J = 7.5 Hz), 4.30 (1H, q, J = 7.5 Hz), 7.65 (2H, d, J = 7.8 Hz), 7.85 (2H, d, J = 7.8 Hz), 8.15 (1H, s). MS (FAB) m/z: 313 (M+ +1).

References

[1] Patent: EP2166015, 2010, A1. Location in patent: Page/Page column 25
[2] European Journal of Inorganic Chemistry, 2015, vol. 2015, # 29, p. 4935 - 4945
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 4, p. 1545 - 1555
[4] Medicinal Chemistry Research, 2016, vol. 25, # 10, p. 2399 - 2409
[5] Research on Chemical Intermediates, 2018, vol. 44, # 2, p. 1247 - 1260

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View Lastest Price from 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER manufacturers

Career Henan Chemical Co

Product: 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 885278-75-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2019-12-31

885278-75-1, 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTERRelated Search:

2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

Ethyl 2-(4-bromophenyl)-1,3-thiazole-4-carboxylate

Ethyl 2-(4-bromophenyl)thiazole-4-carboxylate

4-THIAZOLECARBOXYLICACID, 2-(4-BROMOPHENYL)-, ETHYL ESTER

885278-75-1

Thiazole