ChemicalBook > CAS DataBase List > 2,6-DIAMINO-4-METHYL PYRIDINE

2,6-DIAMINO-4-METHYL PYRIDINE

Product Name: 2,6-DIAMINO-4-METHYL PYRIDINE
CAS No.: 38439-33-7
Chemical Name: 2,6-DIAMINO-4-METHYL PYRIDINE
Synonyms: Fampridine Impurity 32;4-Methyl-2,6-pyridinediamine;4-METHYLPYRIDINE-2,6-DIAMINE;2,6-PyridinediaMine,4-Methyl-;2,6-DIAMINO-4-METHYL PYRIDINE;2,6-DIAMINO-4-METHYL PYRIDINE ISO 9001：2015 REACH
CBNumber: CB8755706
Molecular Formula: C6H9N3
Formula Weight: 123.16
MOL File: 38439-33-7.mol

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2,6-DIAMINO-4-METHYL PYRIDINE Property

Melting point:: 85-86 °C
Boiling point:: 312.5±37.0 °C(Predicted)
Density: 1.190±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 6.79±0.35(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M329075
Product name: 4-Methylpyridine-2,6-diamine
Packaging: 500mg
Price: $130
Updated: 2021/12/16

TRC

Product number: M329075
Product name: 4-Methylpyridine-2,6-diamine
Packaging: 1g
Price: $185
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD151013
Product name: 2,6-Diamino-4-methylpyridine
Packaging: 250mg
Price: $170
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD151013
Product name: 2,6-Diamino-4-methylpyridine
Packaging: 100mg
Price: $86
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD151013
Product name: 2,6-Diamino-4-methylpyridine
Packaging: 500mg
Price: $300
Updated: 2021/12/16

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2,6-DIAMINO-4-METHYL PYRIDINE Chemical Properties,Usage,Production

Uses

4-Methylpyridine-2,6-diamine is a reactant in the preparation of N-(pyridin-2-yl) arylsulfonamides with potent 11β-hydroxysteroid dehydrogenase type 1 activity.

Synthesis

108-89-4

38439-33-7

General procedure for the synthesis of 2,6-diamino-4-methylpyridine from 4-methylpyridine: General method: synthesis of 4-methylpyridine-2,6-diamine (1). Method A: 4-Methylpyridine (15 g, 161.1 mmol) was suspended in mineral oil (220 mL), sodium amide (27.0 g, 483.3 mmol, 3 eq.) was added and stirred overnight at room temperature. Subsequently, the homogeneous suspension was heated to 130 °C and maintained for 15 min, and the beginning of hydrogen precipitation was observed. The temperature was gradually increased to 160 °C over 30 min, the color of the suspension changed from light brown to dark brown and the mixture formed a foamy solid. Continuing heating to 200 °C over 30 min, hydrogen release accelerated and the color of the mixture changed to black. After 3 hours of reaction at 215 °C, complete consumption of the feedstock and completion of hydrogen release was confirmed by TLC (unfolding agent: ethyl acetate/methanol/acetic acid, 10:1:0.1) monitoring. The reaction mixture was cooled to room temperature, the black solid was collected by filtration and washed with petroleum ether (5 x 100 mL). Silica gel (100 g) and 96% ethanol (130 mL) were carefully added to the black solid and evaporated to dryness after 20 min. Subsequently, the solid was placed on top of a suction filter containing silica gel (300 g; ethyl acetate) and eluted using a gradient of ethyl acetate to ethyl acetate/isopropanol (8:1), the product grade was collected and evaporated. The brown residue was recrystallized with tert-butyl methyl ether/diisopropyl ether to give 13.1 g of target product 1 as gray crystals in 66% yield. Method B: The compound was prepared by a similar method to 1 using 2-amino-4-methylpyridine (15 g, 138.7 mmol) and sodium amide (16.2 g, 416.1 mmol, 3 equiv) as starting materials. Yield: 13.2 g (76%). Melting point: 100-102 °C. 1H NMR (DMSO-d6) δ: 5.46 (s, 2H, pyridine ring H), 5.21 (s, 4H, NH2), 1.95 (s, 3H, CH3). 13C{1H} NMR (DMSO-d6) δ: 158.7 (pyridine ring C), 148.1 (pyridine ring C), 96.2 (pyridine ring C). 20.7 (CH3).HRMS (ESI):[M + H]+, measured value 124.0869.Theoretically calculated value 124.0875 for C6H9N3.

References

[1] Tetrahedron Letters, 2016, vol. 57, # 3, p. 333 - 336
[2] Journal of Organic Chemistry, 2001, vol. 66, # 20, p. 6513 - 6522
[3] Journal of the American Chemical Society, 2015, vol. 137, # 25, p. 7998 - 8001
[4] Patent: WO2006/106423, 2006, A2. Location in patent: Page/Page column 29
[5] Journal of the American Chemical Society, 1947, vol. 69, p. 1147,1148

2,6-DIAMINO-4-METHYL PYRIDINE Preparation Products And Raw materials

Raw materials

Ethanol 4-Methylpyridine 1,2,3,4-Tetrahydronaphthalene Sodium amide

Preparation Products

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View Lastest Price from 2,6-DIAMINO-4-METHYL PYRIDINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-Methyl-2,6-pyridinediamine 38439-33-7
Price: US $8.80-1.10/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2025-09-16

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2,6-diamino-4-methylpyridine 38439-33-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-24

Shaanxi Dideu Medichem Co. Ltd

Product: 2,6-DIAMINO-4-METHYL PYRIDINE 38439-33-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

38439-33-7, 2,6-DIAMINO-4-METHYL PYRIDINERelated Search:

2,6-DIAMINO-4-METHYL PYRIDINE 2,6-Diaminopyridine SALOR-INT L118109-1EA SALOR-INT L118117-1EA Amino-6-(N-methoxy-N-methylamino)-3,4,5-pyridinetricarbonitrile AURORA KA-6214 AURORA KA-6201 CHEMPACIFIC 38173 SALOR-INT L118125-1EA 4-METHYL-3-NITROPYRIDINE-2,6-DIAMINE 3-FLUORO-4-METHYLPYRIDINE-2,6-DIAMINE 2-AMINO-4-(CYANOMETHYL)-6-PIPERIDIN-1-YLPYRIDINE-3,5-DICARBONITRILE 2-AMINO-4-(CYANOMETHYL)-6-MORPHOLIN-4-YLPYRIDINE-3,5-DICARBONITRILE SALOR-INT L135666-1EA 2-AMINO-4-(1-CYANO-2-PHENYLETHYL)-6-MORPHOLIN-4-YLPYRIDINE-3,5-DICARBONITRILE 2-AMINO-4-(1-CYANO-2-PHENYLETHYL)-6-PIPERIDIN-1-YLPYRIDINE-3,5-DICARBONITRILE 2-AMINO-4-[(Z)-1-CYANO-2-(4-METHOXYPHENYL)VINYL]-6-PIPERIDIN-1-YLPYRIDINE-3,5-DICARBONITRILE LABOTEST-BB LT00012626

4-METHYLPYRIDINE-2,6-DIAMINE

2,6-DIAMINO-4-METHYL PYRIDINE

4-Methyl-2,6-pyridinediamine

2,6-PyridinediaMine,4-Methyl-

2,6-DIAMINO-4-METHYL PYRIDINE ISO 9001：2015 REACH

Fampridine Impurity 32

38439-33-7