4-HYDROXY-3-NITROCOUMARIN Property

Melting point:

172 °C (dec.) (lit.)

Boiling point:

364.5±42.0 °C(Predicted)

Density 

1.63±0.1 g/cm3(Predicted)

pka

4.50±1.00(Predicted)

form 

powder to crystal

color 

White to Yellow to Green

λmax

329nm(EtOH(50vol%))(lit.)

BRN 

1247343

CAS DataBase Reference

20261-31-8(CAS DataBase Reference)

Safety

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

HS Code 

2932.20.4500

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

4-HYDROXY-3-NITROCOUMARIN Chemical Properties,Usage,Production

Chemical Properties

yellow to tan crystalline powder

Uses

4-Hydroxy-3-nitrocoumarin (cas# 20261-31-8) is a compound useful in organic synthesis.

Uses

4-Hydroxy-3-nitrocoumarin may be used as starting reagent for the synthesis of following compounds:

• 4-chloro-3-nitrocoumarin
• 2-unsubstituted 3-nitrochromone
• 4-amino-3-nitrocoumarins

General Description

4-Hydroxy-3-nitrocoumarin is a coumarin derivative and its cytotoxic action against cultured human tumor and normal cells has been investigated. It can be prepared by the nitration of 4-hydroxycoumarin in glacial acetic acid by using 72% HNO₃.