HEXESTROL

Product Name: HEXESTROL
CAS No.: 84-16-2
Chemical Name: HEXESTROL
Synonyms: Hexron;Estrifar;Estronal;NSC-9894;Synthovo;Sinestrol;Synestrol;Vitestrol;HEXOESTROL;Estra-Plex
CBNumber: CB8758929
Molecular Formula: C18H22O2
Formula Weight: 270.37
MOL File: 84-16-2.mol

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HEXESTROL Property

Melting point:: 186 °C
Boiling point:: 353.48°C (rough estimate)
Density: 1.093
refractive index: 1.4800 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: almost transparency in Methanol
pka: 9.80±0.26(Predicted)
form: Solid
color: White to Almost white
Merck: 14,4701
BRN: 3209460
InChI: InChI=1/C18H22O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,17-20H,3-4H2,1-2H3/t17-,18+
InChIKey: PBBGSZCBWVPOOL-HDICACEKNA-N
SMILES: [C@@H](C1=CC=C(O)C=C1)(CC)[C@@H](C1=CC=C(O)C=C1)CC |&1:0,10,r|
CAS DataBase Reference: 84-16-2(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 45
Safety Statements: 53-45
WGK Germany: 2
RTECS: SL0560850
HS Code: 2907.29.9000
Hazardous Substances Data: 84-16-2(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H7753
Product name: Hexestrol
Purity: analytical standard
Packaging: 1g
Price: $73.9
Updated: 2022/05/15

Sigma-Aldrich

Product number: H7753
Product name: Hexestrol
Purity: analytical standard
Packaging: 5g
Price: $353
Updated: 2022/05/15

TCI Chemical

Product number: D0494
Product name: Hexestrol
Purity: >98.0%(GC)
Packaging: 1g
Price: $57
Updated: 2024/03/01

TCI Chemical

Product number: D0494
Product name: Hexestrol
Purity: >98.0%(GC)
Packaging: 10g
Price: $261
Updated: 2024/03/01

Alfa Aesar

Product number: J60889
Product name: Hexestrol, 98+%
Packaging: 1g
Price: $60.65
Updated: 2024/03/01

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HEXESTROL Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Estra Plex,Rowell,US,1956

Uses

Nonsteroidal synthetic estrogen

Uses

Estrogen; antineoplastic (hormonal).

Manufacturing Process

50 parts by weight of p-hydroxypropiophenone are dissolved in 200 parts by weight of a 12.5% solution of caustic soda and shaken with 350 parts by weight of 3% sodium amalgam. The sodium salt of the pinacol thereby precipitating is reacted with glacial acetic acid, whereby the free pinacol is obtained (MP 205°C to 210°C, after purification 215°C to 217°C). The yield amounts to 95% of the theoretical. The pinacol is suspended in ether and gaseous hydrogen chloride introduced, whereby water separates and the pinacolin formed is dissolved in the ether, from which it is obtained by evaporation as a viscous oil (diacetate of MP 91°C). The yield is quantitative.
40 parts by weight of pinacolin are dissolved in ethyl alcohol and gradually treated with 80 parts by weight of sodium under reflux. The solution is decomposed with water and the pinacolin alcohol formed extracted from the neutalized solution with ether. The pinacolin alcohol is a viscous oil which is characterized by a dibenzoate of MP 172°C. The yield is 95% of the theoretical.
30 parts by weight of pinacolin alcohol are dissolved in 25 parts by weight of glacial acetic acid and heated for 30 minutes to 135°C to 140°C after having added 20 parts by weight of hydroiodic acid (specific gravity = 1.94) and 5 parts by weight of red phosphorus. The whole is filtered, the solution poured into water, extracted with ether and the ether solution washed with bicarbonate. The oil remaining after distilling off the ether is taken up in chloroform, whereby hexoestrol [α,β-(p,p-dihydroxy-diphenyl)-α,β-diethylethane] crystallizes out. MP after recrystallization from benzene: 185°C. Yield: 20%.

Therapeutic Function

Estrogen

Purification Methods

Crystallise meso-Hexestero from *benzene or aqueous EtOH (m 185-188o). The meso-dibenzoyl derivative has m 236-237o. The 3RS,4RS(±)-racemate [5776-72-7] crystallises from pet ether, *C6H6/pet ether, Et2O/pet ether, or MeOH/H2O and has m 128-129o . The (±)-dibenzoyl derivative has m 123-124o . The 3R,4R(+)-isomer [26614-21-1] and 3S,4S(-)-isomer [26614-22-2] crystallise from Et2O/pet ether with m 80 -80.5o and have [] D (+) and (-) 17.7o (c 5, EtOH). Their dibenzoyl derivatives have m 116.5o .[Beilstein 6 III 5503, 6 IV 6761.] They have estrogenic activity where optically active forms are more potent and they have antineoplastic activity. [Aboul-Enein et al. Anal Profiles Drug Subst 11 347 1982, J Am Chem Soc 65 4911941.]

HEXESTROL Preparation Products And Raw materials

Raw materials

cis-Anethol

Preparation Products

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HEXESTROL Suppliers

Americas 1 Canada 1 China 121 Europe 3 Germany 3 India 4 Japan 2 Switzerland 1 United Kingdom 2 United States 26 Global 164

AdooQ BioScience, LLC

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View Lastest Price from HEXESTROL manufacturers

Baoji Guokang Healthchem co.,ltd

Product: HEXESTROL 84-16-2
Price: US $1300.00/KG
Min. Order: 1G
Purity: USP
Supply Ability: 100KGS
Release date: 2021-06-07

Zhuozhou Wenxi import and Export Co., Ltd

Product: HEXESTROL 84-16-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: HEXESTROL 84-16-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

84-16-2, HEXESTROLRelated Search:

Diethylenetriaminepentaacetic acid Poly(oxy-1,2-ethanediyl), .alpha.-phenyl-.omega.-hydroxy- Pentamethyldiethylenetriamine 4-Methoxyphenol Diethylstilbestrol Diethylstilbestrol Bovine urine (hexoestrol blank) 25525 BOVINE URINE (HEXOESTROL POSITIVE Bovine urine (hexoestrol positive) 90344 BOVINE URINE (HEXOESTROL BLANK) Phenyl bromoacetate HEXOESTROL HEXESTROL

Hexanoestrol Solution, 100ppm

Hexestrol solution,100ppm

Hexoestrol&nbsp

Hexestrol(Bibenzyl)

4,4'-(hexane-3,4-diyl)diphenol

Phenol,4,4'-[(1R,2S)-1,2-diethyl-1,2-ethanediyl]bis-, rel-

4,4’-(1,2-diethyl-1,2-ethanediyl)bis-,(r*,s*)-pheno

4,4’-(1,2-diethyl-1,2-ethanediyl)bis-phenol

4,4’-(1,2-diethyl-1,2-ethylenediyl)bis-,(r*,s*)-pheno

4,4’-dihydroxy-alpha,beta-diethyldiphenylethane

4,4’-dihydroxy-gamma,delta-diphenylhexane

4,4'-Dihydroxy-alpha,beta-diethyldiphenylethane

4,4'-Dihydroxy-gamma,delta-diphenylhexane

4’-(1,2-diethylethylene)di-meso-pheno

alpha,alpha’-diethyl-4,4’-dihydroxy-bibenzy

3,4-bis(p-hydroxyphenyl)-hexan

4,4'-(1,2-DIETHYLETHYLENE)DIPHENOL

MESO-3,4-BIS[4-HYDROXYPHENYL]-HEXANE

DIHYDRODIETHYLSTILBESTROL

HEXOESTROLUM

HEXOESTROL

(R*,S*)-4,4'-(1,2-diethylethylene)bis(phenol)

HEXESTEROL VETRANAL, 250 MG

DL-HEXESTROL

MESO-HEXOESTROL

4,4''-(1,2-DIETHYLETHYLENE)DIPHENOL 98+%

rel-4,4'-[(1R,2S)-1,2-Diethyl-1,2-ethanediyl]bisphenol

4,4μ-(1,2-Diethylethylene)diphenol, meso-3,4-Bis(4-hydroxyphenyl)hexane, Dihydrodiethylstilbestrol

[CH(C2H5)C6H4OH]2

2-(1-hydroxycyclohexyl)acetic acid butyl ester

3,4-BIS-(P-HYDROXYPHENYL)-HEXANE

3,4-DI(P-HYDROXYPHENYL)HEXANE

alpha,alpha’-diethyl-4,4’dihydroxy-bibenzy

Bibenzyl, alpha,alpha'-diethyl-4,4'-dihydroxy-

Cycloestrol

dihydro-stilbestro

Dihydrostilbestrol

Estra-Plex

Estrifar

Estronal

Extra-Plex

gamma,delta-Di(p-hydroxyphenyl)-hexane

Hexane, 3,4-bis(p-hydroxyphenyl)-

Hexanoestrol

Hexestrofen

Hexron

Hormoestrol

meso-3,4-Bis(p-hydroxyphenyl)-n-hexane

meso-3,4-Di(p-hydroxyphenyl)-n-hexane

meso-Hexestrol

NSC-9894

Phenol, 4,4'-(1,2-diethyl-1,2-ethanediyl)bis-, (R*,S*)-

Phenol, 4,4'-(1,2-diethyl-1,2-ethylenediyl)bis-, (R*,S*)-

Phenol, 4,4'-(1,2-diethylethylene)di-

Phenol, 4,4'-(1,2-diethylethylene)di-, meso-

Sinestrol

Stilbestrol, dihydro-

Synestrol