(S)-5-AMINO-PIPERIDIN-2-ONE HCL
Application- Product Name
- (S)-5-AMINO-PIPERIDIN-2-ONE HCL
- CAS No.
- 672883-95-3
- Chemical Name
- (S)-5-AMINO-PIPERIDIN-2-ONE HCL
- Synonyms
- (S)-5-AMINO-PIPERIDIN-2-O;4-(S)-AMINO-D-VALEROLACTAM HCL;(S)-5-AMINO-PIPERIDIN-2-ONE HCL;(S)-5-AMINOPIPERIDIN-2-ONE HYDROCHLORIDE;(5S)-5-aminopiperidin-2-one hydrochloride;(S)-4-Amino-delta-valerolactam hydrochloride;(5S)-5-Aminopiperidin-2-one . x hydrochloride;(S)-5-AMINO-PIPERIDIN-2-ONEHCL (MFCD03094719);2-Piperidinone, 5-amino-, monohydrochloride, (5S)-
- CBNumber
- CB8768735
- Molecular Formula
- C5H11ClN2O
- Formula Weight
- 150.61
- MOL File
- 672883-95-3.mol
(S)-5-AMINO-PIPERIDIN-2-ONE HCL Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- color
- White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A633725
- Product name
- (S)-5-Aminopiperidin-2-onehydrochloride
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- OR480824
- Product name
- (5S)-5-Aminopiperidin-2-onehydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $653
- Updated
- 2021/12/16
- Product number
- L21629
- Product name
- (5S)-5-Aminopiperidin-2-onehydrochloride
- Purity
- 97%
- Packaging
- 250MG
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 672883953
- Product name
- (S)-5-Aminopiperidin-2-onehydrochloride
- Packaging
- 250mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- L21629
- Product name
- (5S)-5-Aminopiperidin-2-onehydrochloride
- Purity
- 97%
- Packaging
- 1G
- Price
- $400
- Updated
- 2021/12/16
(S)-5-AMINO-PIPERIDIN-2-ONE HCL Chemical Properties,Usage,Production
Application
(S)-5-amino-piperidin-2-one hydrochloride is an organic intermediate that can be prepared from L-glutamic acid-5-methyl ester through a six-step reaction.
Synthesis
Starting with L-glutamic acid-5-methyl ester, it was first reacted with di-tert-butyl dicarbonate in a triethylamine/DMF system at 50°C for 1 hour, then incubated overnight at room temperature. Column chromatography yielded a Boc-protected intermediate. This intermediate was dissolved in THF, reduced at -10°C with N-methylmorpholine, ethyl chloroformate, and sodium borohydride, quenched with saturated ammonium chloride, and purified by extraction to obtain a hydroxyl intermediate. This hydroxyl intermediate was then reacted with p-toluenesulfonyl chloride and triethylamine in dichloromethane at room temperature, and column chromatography yielded a sulfonyloxy intermediate. Subsequently, it was heated with sodium azide in DMF at 50°C for 3 hours to purify an azide intermediate. The azide intermediate was dissolved in methanol and hydrogenated overnight under atmospheric pressure using a 10% palladium/carbon catalyst. The solvent was removed by filtration to obtain a cyclization product. Finally, the cyclization product was dissolved in ethanol, and acetyl chloride was added at 0°C. The mixture was stirred at room temperature for 1 hour, and the solvent was removed under reduced pressure to obtain (S)-5-amino-piperidin-2-one hcl.
(S)-5-AMINO-PIPERIDIN-2-ONE HCL Preparation Products And Raw materials
Raw materials
Preparation Products
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