2-CHLORO-5-METHYL-NICOTINIC ACID METHYL ESTER
- Product Name
- 2-CHLORO-5-METHYL-NICOTINIC ACID METHYL ESTER
- CAS No.
- 65169-43-9
- Chemical Name
- 2-CHLORO-5-METHYL-NICOTINIC ACID METHYL ESTER
- Synonyms
- 2-CHLORO-5-METHYL-NICOTINIC ACID METHYL ESTER;3-Pyridinecarboxylic acid, 2-chloro-5-methyl-, methyl ester
- CBNumber
- CB8791179
- Molecular Formula
- C8H8ClNO2
- Formula Weight
- 185.61
- MOL File
- Mol file
2-CHLORO-5-METHYL-NICOTINIC ACID METHYL ESTER Property
- Boiling point:
- 270.1±35.0 °C(Predicted)
- Density
- 1.247±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- pka
- -0.99±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ADE000763
- Product name
- Methyl 2-chloro-5-methylnicotinate
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $817
- Updated
- 2025/07/31
- Product number
- M295630
- Product name
- Methyl 2-chloro-5-methylnicotinate
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 054092
- Product name
- Methyl 2-chloro-5-methylnicotinate
- Packaging
- 100mg
- Price
- $49
- Updated
- 2021/12/16
- Product number
- 054092
- Product name
- Methyl 2-chloro-5-methylnicotinate
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- OR952283
- Product name
- Methyl 2-chloro-5-methylnicotinate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
2-CHLORO-5-METHYL-NICOTINIC ACID METHYL ESTER Chemical Properties,Usage,Production
Synthesis
13061-96-6
78686-79-0
65169-43-9
General procedure for the synthesis of methyl 2-chloro-5-methylnicotinate from methylboronic acid and methyl 5-bromo-2-chloronicotinate: To a toluene solution (16 mL) of methyl 5-bromo-2-chloronicotinate (1.05 g, 4.19 mmol), K3PO4 (2.95 g, 13.90 mmol), methylboronic acid (0.32 g, 5.26 mmol) and tricyclohexylphosphine (0.11 g, 0.39 mmol) in a toluene solution (16 mL) under nitrogen atmosphere, water (0.8 mL) was added followed by Pd(OAc)2 (0.04 g, 0.18 mmol). The mixture was heated at 100 °C under nitrogen atmosphere for overnight reaction. After completion of the reaction, the mixture was cooled to room temperature and concentrated under vacuum. Ethyl acetate was added to the residue and the organic layer was washed sequentially with water and brine, dried with MgSO4, filtered and the solvent was evaporated under vacuum to afford the target product methyl 2-chloro-5-methylnicotinate as a yellow oil in 87% yield.LRMS: m/z 186 (M + 1)+, retention time: 4.84 min.
References
[1] Patent: WO2008/77639, 2008, A1. Location in patent: Page/Page column 26
2-CHLORO-5-METHYL-NICOTINIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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