FIDAS-3

Product Name: FIDAS-3
CAS No.: 1266684-01-8
Chemical Name: FIDAS-3
Synonyms: FIDAS-3;FIDAS-3 ，E0081;FIDAS-3, 10 mM in DMSO;Wnt Pathway Inhibitor XII;(E)-4-(2,6-Difluorostyryl)-N,N-dimethylaniline;Benzenamine, 4-[(1E)-2-(2,6-difluorophenyl)ethenyl]-N,N-dimethyl-;FIDAS-3,Inhibitor,Wnt,CyclinD1,anti-proliferation,FIDAS3,FIDAS 3,c-Myc,MAT2A,β-catenin,S-adenosylmethionine,anti-cancer,SAH,inhibit,SAM
CBNumber: CB88054403
Molecular Formula: C16H15F2N
Formula Weight: 259.29
MOL File: 1266684-01-8.mol

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FIDAS-3 Property

Boiling point:: 355.8±30.0 °C(Predicted)
Density: 1.183±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 100 mg/mL (385.67 mM; Need ultrasonic)
form: A solid
pka: 4.68±0.24(Predicted)
color: off-white to pale yellow

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Hazard and Precautionary Statements (GHS)

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FIDAS-3 Chemical Properties,Usage,Production

Uses

FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2].

Biological Activity

FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2]. FIDAS-3 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells[1]. FIDAS-3 (3-10 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. And FIDAS-3 induces the expression of cell cycle inhibitor, p21WAF1/CIP1[1]. FIDAS-3 (10 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells[1]. FIDAS-3 (20 mg/kg; intraperitoneal injection; daily; for one months; C57BL/6J athymic nude mice) treatment significantly inhibits the growth of xenograft tumors[2].

in vivo

FIDAS-3 (20 mg/kg; intraperitoneal injection; daily; for one months; C57BL/6J athymic nude mice) treatment significantly inhibits the growth of xenograft tumors^[2].

Animal Model:	C57BL/6J athymic nude mice (6-8 week) injected with LS174 cells^[2]
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection; daily; for one months
Result:	Significantly inhibited the growth of xenograft tumors.

References

[1]. Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8(4):796-803. [2]. Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. J Med Chem. 2011 Mar 10;54(5):1288-97.

FIDAS-3 Preparation Products And Raw materials

Raw materials

Preparation Products

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FIDAS-3 Suppliers

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1266684-01-8, FIDAS-3Related Search:

FIDAS-3

FIDAS-3,Inhibitor,Wnt,CyclinD1,anti-proliferation,FIDAS3,FIDAS 3,c-Myc,MAT2A,β-catenin,S-adenosylmethionine,anti-cancer,SAH,inhibit,SAM

Benzenamine, 4-[(1E)-2-(2,6-difluorophenyl)ethenyl]-N,N-dimethyl-

(E)-4-(2,6-Difluorostyryl)-N,N-dimethylaniline

FIDAS-3, 10 mM in DMSO

Wnt Pathway Inhibitor XII

FIDAS-3 ，E0081

1266684-01-8