ChemicalBook > CAS DataBase List > GSK-3484862
GSK-3484862
- Product Name
- GSK-3484862
- CAS No.
- 2170136-65-7
- Chemical Name
- GSK-3484862
- Synonyms
- GSK-3484862;GSK-3484862 (GSKMI-714);GSK-3484862, 10 mM in DMSO;Benzeneacetamide, α-[[3,5-dicyano-6-(dimethylamino)-4-ethyl-2-pyridinyl]thio]-, (αR)-;inhibit,methyltransferase1,5-Azacytidine,Inhibitor,hypomethylation,Dnmt1,therapies,GSK3484862,DNA MTases,DNA,GSK-3484862,epigenetic,DNA Methyltransferase,DNMTs,GSK 3484862
- CBNumber
- CB88054418
- Molecular Formula
- C19H19N5OS
- Formula Weight
- 365.45
- MOL File
- 2170136-65-7.mol
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GSK-3484862 Property
- Boiling point:
- 620.5±55.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- solubility
- DMSO:20.83(Max Conc. mg/mL);57.0(Max Conc. mM)
- pka
- 14.62±0.50(Predicted)
- form
- Solid
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0109599
- Product name
- GSK-3484862
- Purity
- 99.94%
- Packaging
- 10mg
- Price
- $250
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0109599
- Product name
- GSK-3484862
- Purity
- 99.94%
- Packaging
- 50mg
- Price
- $650
- Updated
- 2021/12/16
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GSK-3484862 Chemical Properties,Usage,Production
Description
GSK-3484862 is a non-covalent inhibitor for Dnmt1. GSK-3484862 induces DNA hypomethylation to against cancer.
in vitro
In total, methylation mapping supports the conclusion that GSK-3484862 treatment produces a drop in DNA methylation consistent with selective and near complete inhibition of DNMT1._x000D_ _x000D_ Reference: Epigenetics Chromatin. 2021 Dec 15;14(1):56. https://pubmed.ncbi.nlm.nih.gov/34906184/
target
GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer.
GSK-3484862 Preparation Products And Raw materials
Raw materials
Preparation Products
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