SMS1-IN-1

Product Name: SMS1-IN-1
CAS No.: 1807943-38-9
Chemical Name: SMS1-IN-1
Synonyms: SAPA-1j;SMS1-IN-1;SMS1-IN-1, 10 mM in DMSO;SAPA-1j N-(4-bromobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide;N-[(4-bromophenyl)methyl]-2-[4-(2-phenylethylsulfamoyl)phenoxy]acetamide;atherosclerosis,SMS-1-IN-1,SMS1 IN 1,inhibit,SM biosynthetic,Inhibitor,SMS1IN1;Acetamide, N-[(4-bromophenyl)methyl]-2-[4-[[(2-phenylethyl)amino]sulfonyl]phenoxy]-
CBNumber: CB88054544
Molecular Formula: C23H23BrN2O4S
Formula Weight: 503.41
MOL File: 1807943-38-9.mol

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SMS1-IN-1 Property

Density: 1.409±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 250 mg/mL (496.61 mM; Need ultrasonic)
form: Solid
pka: 11.73±0.50(Predicted)
color: Off-white to brown

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Hazard and Precautionary Statements (GHS)

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SMS1-IN-1 Chemical Properties,Usage,Production

Uses

SMS1-IN-1, compound SAPA 1j, is a novel and the most potent sphingomyelin synthase 1 (SMS1) inhibitor with an IC50 value of 2.1 μM. SMS1-IN-1 has the potential for the treatment of atherosclerosis[1].

Biological Activity

SMS1-IN-1, compound SAPA 1j, is a novel and the most potent sphingomyelin synthase 1 (SMS1) inhibitor with an IC50 value of 2.1 μM. SMS1-IN-1 has the potential for the treatment of atherosclerosis[1]. SMS1-IN-1 (2.5, 10 and 50 μM) has a dose-dependent inhibitory effect against SMS1, and is against SMS1 with an IC50 value of 2.1 μM[1].

References

[1]. Li YL, et al. Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors.Bioorg Med Chem. 2015 Sep 15;23(18):6173-84.

SMS1-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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SMS1-IN-1 Suppliers

China 26 United States 1 Global 27

Shanghaizehan biopharma technology co., Ltd.

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Shanghai Dongyang Biotechnology Co., Ltd.

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InvivoChem

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1807943-38-9, SMS1-IN-1Related Search:

SMS1-IN-1

SAPA-1j

SAPA-1j N-(4-bromobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide

atherosclerosis,SMS-1-IN-1,SMS1 IN 1,inhibit,SM biosynthetic,Inhibitor,SMS1IN1

Acetamide, N-[(4-bromophenyl)methyl]-2-[4-[[(2-phenylethyl)amino]sulfonyl]phenoxy]-

SMS1-IN-1, 10 mM in DMSO

N-[(4-bromophenyl)methyl]-2-[4-(2-phenylethylsulfamoyl)phenoxy]acetamide

1807943-38-9