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UCB-9260

Product Name
UCB-9260
CAS No.
1515888-53-5
Chemical Name
UCB-9260
Synonyms
UCB-9260;UCB-9260 ，S3231;UCB-9260, 10 mM in DMSO;(1-(2,5-dimethylbenzyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-2-yl)(pyridin-4-yl)methanol;1-[(2,5-Dimethylphenyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-α-4-pyridinyl-1H-benzimidazole-2-methanol;1H-Benzimidazole-2-methanol, 1-[(2,5-dimethylphenyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-α-4-pyridinyl-;cytotoxicity,asymmetric,trimer,Inhibitor,neutrophil,autoimmune,Tumor Necrosis Factor Receptor,UCB-9260,TNFR,rheumatoid,arthritis,inhibit,UCB 9260,TNF Receptor,cytokine,selective,UCB9260
CBNumber
CB88054610
Molecular Formula
C26H25N5O
Formula Weight
423.51
MOL File
1515888-53-5.mol
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UCB-9260 Property

Boiling point:
722.0±60.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 125 mg/mL (295.15 mM; Need ultrasonic)
pka
11.97±0.20(Predicted)
form 
Solid
color 
Brown to gray
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

DC Chemicals
Product number
026089
Product name
UCB-9260
Packaging
001
Price
$700
Updated
2021/12/16
DC Chemicals
Product number
026089
Product name
UCB-9260
Packaging
002
Price
$1200
Updated
2021/12/16
DC Chemicals
Product number
026089
Product name
UCB-9260
Packaging
003
Price
$2200
Updated
2021/12/16
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UCB-9260 Chemical Properties,Usage,Production

Uses

UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer.UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similarKdof 13nM[1].

in vivo

UCB-9260 (150mg/kg; p.o.;twice dailyfor 7 days) shows a significant reduction of the clinical score[1].
UCB-9260(10-300mg/kg; p.o.) dose-dependently inhibits human and mouse TNF-induced neutrophil recruitment to the peritoneal compartment in adult male Balb/c mice[1].

Animal Model:Aged 6-8 weeks adult male Balb/c mice(CAIA model)[1]
Dosage:150mg/kg
Administration:p.o.; twice daily for 7days
Result:Showed a significant reduction of the clinical score.

References

[1] O'Connell J, et al.SmallmoleculesthatinhibitTNFsignallingbystabilisinganasymmetricformof thetrimer.Nat Commun.2019 Dec 19;10(1):5795. DOI:10.1038/s41467-019-13616-1

UCB-9260 Preparation Products And Raw materials

Raw materials

Preparation Products

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UCB-9260 Suppliers

China 45 United States 3 Global 48
Wuhan TCASChem Technology Co., Ltd.
Tel
027-86697669 13986148687
Fax
86-027-86697669
Email
sales@tcaschem.com
Country
China
ProdList
3993
Advantage
55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4817
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
7999
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2985
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9505
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29661
Advantage
68
Zhengzhou Huiju Chemical Co., Ltd.
Tel
0371-55900031 18137872243
Email
3927209986@qq.com
Country
China
ProdList
10000
Advantage
55
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471;
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58

1515888-53-5, UCB-9260Related Search:


  • UCB-9260
  • (1-(2,5-dimethylbenzyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-2-yl)(pyridin-4-yl)methanol
  • cytotoxicity,asymmetric,trimer,Inhibitor,neutrophil,autoimmune,Tumor Necrosis Factor Receptor,UCB-9260,TNFR,rheumatoid,arthritis,inhibit,UCB 9260,TNF Receptor,cytokine,selective,UCB9260
  • 1H-Benzimidazole-2-methanol, 1-[(2,5-dimethylphenyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-α-4-pyridinyl-
  • UCB-9260, 10 mM in DMSO
  • UCB-9260 ，S3231
  • 1-[(2,5-Dimethylphenyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-α-4-pyridinyl-1H-benzimidazole-2-methanol
  • 1515888-53-5