ChemicalBook > CAS DataBase List > TED-347

TED-347

Product Name: TED-347
CAS No.: 2378626-29-8
Chemical Name: TED-347
Synonyms: TED-347;TED-347, 10 mM in DMSO;Ethanone, 2-chloro-1-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]-;2-Chloro-1-(2-((3-(trifluoromethyl)phenyl)amino)phenyl)ethan-1-one;TED-347 2-Chloro-1-(2-((3-(trifluoromethyl)phenyl)amino)-phenyl)ethan-1-one;PPI,irreversible,protein-protein,YAP,allosteric,TEAD4?Yap1,transcriptional,glioblastoma,TED 347,YAP-TEAD,TEAD4,inhibit,Yes-associated protein,covalent,Yap1,antitumor,Inhibitor,TED-347,TED347,TEAD,interaction,Cys-367
CBNumber: CB88054872
Molecular Formula: C15H11ClF3NO
Formula Weight: 313.7
MOL File: 2378626-29-8.mol

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TED-347 Property

Boiling point:: 378.0±42.0 °C(Predicted)
Density: 1.352±0.06 g/cm3(Predicted)
pka: -2.67±0.50(Predicted)
form: Solid
color: Light yellow to green yellow
InChI: InChI=1S/C15H11ClF3NO/c16-9-14(21)12-6-1-2-7-13(12)20-11-5-3-4-10(8-11)15(17,18)19/h1-8,20H,9H2
InChIKey: JPVDFGYNLUBCSD-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1)CCl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0090177
Product name: TED-347
Purity: 98.78%
Packaging: 1mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0090177
Product name: TED-347
Purity: 98.78%
Packaging: 5mg
Price: $130
Updated: 2021/12/16

ChemScene

Product number: CS-0090177
Product name: TED-347
Purity: 98.78%
Packaging: 10mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-0090177
Product name: TED-347
Purity: 98.78%
Packaging: 25mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0090177
Product name: TED-347
Purity: 98.78%
Packaging: 50mg
Price: $760
Updated: 2021/12/16

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TED-347 Chemical Properties,Usage,Production

Uses

TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4?Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a Ki of 10.3 μM. TED-347 blocks TEAD transcriptional activity and has antitumor activity[1].

IC 50

YAP/TAZ-TEAD

References

[1] Khuchtumur Bum-Erdene, et al. Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD?Yap Protein-Protein Interaction. Cell Chem Biol. 2019 Mar 21;26(3):378-389.e13. DOI:10.1016/j.chembiol.2018.11.010

TED-347 Preparation Products And Raw materials

Raw materials

Preparation Products

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2378626-29-8, TED-347Related Search:

TED-347

Ethanone, 2-chloro-1-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]-

TED-347 2-Chloro-1-(2-((3-(trifluoromethyl)phenyl)amino)-phenyl)ethan-1-one

PPI,irreversible,protein-protein,YAP,allosteric,TEAD4?Yap1,transcriptional,glioblastoma,TED 347,YAP-TEAD,TEAD4,inhibit,Yes-associated protein,covalent,Yap1,antitumor,Inhibitor,TED-347,TED347,TEAD,interaction,Cys-367

TED-347, 10 mM in DMSO

2-Chloro-1-(2-((3-(trifluoromethyl)phenyl)amino)phenyl)ethan-1-one

2378626-29-8