MORPHOLIN-4-YL-PHENYL-ACETIC ACID HYDROCHLORIDE

MORPHOLIN-4-YL-PHENYL-ACETIC ACID HYDROCHLORIDE Property

storage temp. 

Sealed in dry,Room Temperature

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

MORPHOLIN-4-YL-PHENYL-ACETIC ACID HYDROCHLORIDE Chemical Properties,Usage,Production

Synthesis

Preparation of 2-morpholino-2-phenylacetic acid hydrochloride (I39): ethyl 2-morpholino-2-phenylacetate (0.34 g, 1.36 mmol) was dissolved in dioxane (11.4 mL) and 37% hydrochloric acid (1.1 mL, 13.6 mmol) was added slowly and dropwise. The reaction mixture was stirred under reflux conditions overnight. 37% hydrochloric acid (1.1 mL, 13.6 mmol) was added again and the reaction was continued at reflux for 24 hours. Upon completion of the reaction, the solvent was removed by evaporation and the residue was ground with acetonitrile (10 mL) to afford 2-morpholino-2-phenylacetic acid hydrochloride as a white solid (0.22 g, 63.7% yield).1H NMR (300 MHz, DMSO-d6) δ 11.79 (s, 1H), 7.56-7.72 (m, 2H), 7.37-7.56 (m, 3H) , 5.25 (s, 1H), 3.60-4.10 (m, 4H), 3.27 (br.s, 2H), 2.96 (br.s, 2H).

References

[1] Patent: WO2013/98145, 2013, A1. Location in patent: Page/Page column 50
[2] Patent: US2013/172302, 2013, A1. Location in patent: Paragraph 0177; 0180; 0181