ChemicalBook > CAS DataBase List > N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide

N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide

Product Name: N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide
CAS No.: 1995067-59-8
Chemical Name: N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide
Synonyms: MCC7840;Emlenoflast;MCC7840 sodium;Inzomelid;N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-1-isopropyl-1H-pyrazole-3-sulfonamide;N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide;1H-Pyrazole-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-1-(1-methylethyl)-;MCC 7840,sulfonylurea,Emlenoflast,NLRP3,inhibit,NOD-like Receptor (NLR),MCC-7840,inflammatory,inflammasome,Inhibitor
CBNumber: CB88058517
Molecular Formula: C19H24N4O3S
Formula Weight: 388.48
MOL File: 1995067-59-8.mol

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N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide Property

Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 1.50±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide Chemical Properties,Usage,Production

Uses

Emlenoflast (MCC7840), a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. Emlenoflast can be used for the research of inflammatory diseases[1][2].

in vivo

Emlenoflast (4 mg/kg; i.v.) exhibits the half-life (3.39 h), AUC_0-last (107097 ng?h/mL) and CL (0.621 mL/min/kg) in mice^[2].
Emlenoflast (20 mg/kg; p.o.) exhibits the oral bioavailability (67.2%), C_max (60467 ng/mL) and half-life (5.02 h) in mice^[2].

Animal Model:	Male C57BL/6 mice (7-9 weeks)^[2]
Dosage:	4 mg/kg for i.v. and 20 mg/kg for p.o. (Pharmacokinetic Analysis)
Administration:	A single intravenousbolus or oral gavage
Result:	I.v.: t_1/2=3.39 h; AUC_0-last=107097 ng?h/mL; CL=0.621 mL/min/kg. P.o.: F=67.2%; C_max=60467 ng/mL; t_1/2=5.02 h.

IC 50

NLRP3 inflammasome: <100 nM (IC₅₀)

References

[1] El-Sharkawy LY, et, al. Inhibiting the NLRP3 Inflammasome. Molecules. 2020 Nov 25;25(23):5533. DOI:10.3390/molecules25235533
[2] O'neill L, et, al. Sulfonylureas and related compounds and use of same. WO2016131098A1.

N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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1995067-59-8, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamideRelated Search:

N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide

1H-Pyrazole-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-1-(1-methylethyl)-

MCC7840 sodium

Emlenoflast

MCC7840

N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-1-isopropyl-1H-pyrazole-3-sulfonamide

MCC 7840,sulfonylurea,Emlenoflast,NLRP3,inhibit,NOD-like Receptor (NLR),MCC-7840,inflammatory,inflammasome,Inhibitor

Inzomelid

1995067-59-8