L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl ester
- Product Name
- L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl ester
- CAS No.
- 1998705-64-8
- Chemical Name
- L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl ester
- Synonyms
- AT-511;Bemnifosbuvir;Bemnifosbuvir(AT-511);Bemnifosbuvir, 10 mM in DMSO;AT-511(Bemnifosbuvir free base);L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl ester;guanosine,pangenotypic,Hepatitis C virus,SARS coronavirus,inhibit,HCV,Bemnifosbuvir,Inhibitor,antiviral,AT 511,SARS-CoV,nucleotide,phosphoramidate,AT511;Isopropyl ((((2R,3R,4R,5R)-5-(2-amino-6-(methylamino)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate;propan-2-yl (2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-[2-amino-6-(methylamino)-9H-purin-9-yl]-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate
- CBNumber
- CB88088637
- Molecular Formula
- C24H33FN7O7P
- Formula Weight
- 581.53
- MOL File
- 1998705-64-8.mol
L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl ester Property
- Boiling point:
- 781.9±70.0 °C(Predicted)
- Density
- 1.54±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO : 100 mg/mL (171.96 mM; Need ultrasonic)
- form
- A solid
- pka
- 12.43±0.70(Predicted)
- color
- Off-white to light yellow
- InChIKey
- OISLSHLAXHALQZ-NPGFSVGSNA-N
- SMILES
- C[C@]1([C@@H]([C@@H](COP(=O)(N[C@@H](C)C(=O)OC(C)C)OC2C=CC=CC=2)O[C@H]1N1C=NC2=C(N=C(N)N=C12)NC)O)F |&1:1,2,3,9,25,r|
N-Bromosuccinimide Price
- Product number
- 020440
- Product name
- AT-511
- Packaging
- 002
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 020440
- Product name
- AT-511
- Packaging
- 004
- Price
- $550
- Updated
- 2021/12/16
- Product number
- 020440
- Product name
- AT-511
- Packaging
- 006
- Price
- $950
- Updated
- 2021/12/16
L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl ester Chemical Properties,Usage,Production
Uses
Bemnifosbuvir (AT-511) is a potent and orally active HCV viral replication inhibitor. Bemnifosbuvir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC90=0.47 μM). Bemnifosbuvir has pangenotypic antiviral activity[1][2][3].
in vivo
When given orally to rats (500 mg/kg) and monkeys (30 mg/kg, 100 mg/kg or 300 mg/kg), Bemnifosbuvir preferentially delivers high levels of AT-9010 in the liver in vivo[1].
References
[1] Steven S Good, et al. Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus. PLoS One. 2020 Jan 8;15(1):e0227104. DOI:10.1371/journal.pone.0227104
[2] Steven S Good, et al. AT-527, a double prodrug of a guanosine nucleotide analog, is a potent inhibitor of SARS-CoV-2 in vitro and a promising oral antiviral for treatment of COVID-19. Antimicrob Agents Chemother. 2021 Feb 8;AAC.02479-20. DOI:10.1128/AAC.02479-20
[3] Elina Berliba, et al. Safety, pharmacokinetics and antiviral activity of AT-527, a novel purine nucleotide prodrug, in HCV-infected subjects with and without cirrhosis. Antimicrob Agents Chemother. 2019 Sep 30;63(12):e01201-19. DOI:10.1128/AAC.01201-19
L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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