ChemicalBook > CAS DataBase List > L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl ester

L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl ester

Product Name
L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl ester
CAS No.
1998705-64-8
Chemical Name
L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl ester
Synonyms
AT-511;Bemnifosbuvir;Bemnifosbuvir(AT-511);Bemnifosbuvir, 10 mM in DMSO;AT-511(Bemnifosbuvir free base);L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl ester;guanosine,pangenotypic,Hepatitis C virus,SARS coronavirus,inhibit,HCV,Bemnifosbuvir,Inhibitor,antiviral,AT 511,SARS-CoV,nucleotide,phosphoramidate,AT511;Isopropyl ((((2R,3R,4R,5R)-5-(2-amino-6-(methylamino)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate;propan-2-yl (2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-[2-amino-6-(methylamino)-9H-purin-9-yl]-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate
CBNumber
CB88088637
Molecular Formula
C24H33FN7O7P
Formula Weight
581.53
MOL File
1998705-64-8.mol
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L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl ester Property

Boiling point:
781.9±70.0 °C(Predicted)
Density 
1.54±0.1 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
DMSO : 100 mg/mL (171.96 mM; Need ultrasonic)
form 
A solid
pka
12.43±0.70(Predicted)
color 
Off-white to light yellow
InChIKey
OISLSHLAXHALQZ-NPGFSVGSNA-N
SMILES
C[C@]1([C@@H]([C@@H](COP(=O)(N[C@@H](C)C(=O)OC(C)C)OC2C=CC=CC=2)O[C@H]1N1C=NC2=C(N=C(N)N=C12)NC)O)F |&1:1,2,3,9,25,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals
Product number
020440
Product name
AT-511
Packaging
002
Price
$200
Updated
2021/12/16
DC Chemicals
Product number
020440
Product name
AT-511
Packaging
004
Price
$550
Updated
2021/12/16
DC Chemicals
Product number
020440
Product name
AT-511
Packaging
006
Price
$950
Updated
2021/12/16
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L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl ester Chemical Properties,Usage,Production

Uses

Bemnifosbuvir (AT-511) is a potent and orally active HCV viral replication inhibitor. Bemnifosbuvir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC90=0.47 μM). Bemnifosbuvir has pangenotypic antiviral activity[1][2][3].

in vivo

When given orally to rats (500 mg/kg) and monkeys (30 mg/kg, 100 mg/kg or 300 mg/kg), Bemnifosbuvir preferentially delivers high levels of AT-9010 in the liver in vivo[1].

References

[1] Steven S Good, et al. Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus. PLoS One. 2020 Jan 8;15(1):e0227104. DOI:10.1371/journal.pone.0227104
[2] Steven S Good, et al. AT-527, a double prodrug of a guanosine nucleotide analog, is a potent inhibitor of SARS-CoV-2 in vitro and a promising oral antiviral for treatment of COVID-19. Antimicrob Agents Chemother. 2021 Feb 8;AAC.02479-20. DOI:10.1128/AAC.02479-20
[3] Elina Berliba, et al. Safety, pharmacokinetics and antiviral activity of AT-527, a novel purine nucleotide prodrug, in HCV-infected subjects with and without cirrhosis. Antimicrob Agents Chemother. 2019 Sep 30;63(12):e01201-19. DOI:10.1128/AAC.01201-19

L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl ester Suppliers

China 41 United States 5 Global 46
BOC Sciences
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1-631-485-4226; 16314854226
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+1-781-999-5354; +17819995354
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1998705-64-8, L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl esterRelated Search:


  • L-Alanine, N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-, 1-methylethyl ester
  • AT-511
  • Bemnifosbuvir
  • guanosine,pangenotypic,Hepatitis C virus,SARS coronavirus,inhibit,HCV,Bemnifosbuvir,Inhibitor,antiviral,AT 511,SARS-CoV,nucleotide,phosphoramidate,AT511
  • Isopropyl ((((2R,3R,4R,5R)-5-(2-amino-6-(methylamino)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
  • propan-2-yl (2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-[2-amino-6-(methylamino)-9H-purin-9-yl]-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate
  • Bemnifosbuvir(AT-511)
  • AT-511(Bemnifosbuvir free base)
  • Bemnifosbuvir, 10 mM in DMSO
  • 1998705-64-8
  • C24H33FN7O7P