C12-200
- Product Name
- C12-200
- CAS No.
- 1220890-25-4
- Chemical Name
- C12-200
- Synonyms
- C12-200;C-12-200,C12200,C12 200;1-[2-[Bis(2-hydroxydodecyl)amino]ethyl-[2-[4-[2-[bis(2-hydroxydodecyl)amino]ethyl]piperazin-1-yl]ethyl]amino]dodecan-2-ol;2-Dodecanol, 1,1'-[[2-[4-[2-[[2-[bis(2-hydroxydodecyl)amino]ethyl](2-hydroxydodecyl)amino]ethyl]-1-piperazinyl]ethyl]imino]bis-;1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)
- CBNumber
- CB88125233
- Molecular Formula
- C70H145N5O5
- Formula Weight
- 1136.93
- MOL File
- 1220890-25-4.mol
C12-200 Property
- Boiling point:
- 1017.6±65.0 °C(Predicted)
- Density
- 0.948±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in Ethanol, DMSO, DMF
- form
- Liquid
- pka
- 14.45±0.20(Predicted)
- color
- Colorless to light yellow
- InChIKey
- RVHYPUORVDKRTM-UHFFFAOYSA-N
- SMILES
- N(CC(O)CCCCCCCCCC)(CC(O)CCCCCCCCCC)CCN1CCN(CCN(CCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)CC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
C12-200 Chemical Properties,Usage,Production
Description
C12-200 is a branched-chain ionizable cationic lipidoid with five hydroxyl groups. It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA, siRNA, or self-amplifying RNA (saRNA). The hydroxyl groups enables further derivatization or replacement with other reactive functional groups.
Uses
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B[1][2][3].
in vivo
C12-200 (0.25 or 0.5 mg/kg, i.v., single injection) delivers exogenous human mRNA, producing target proteins at supraphysiological levels. Human erythropoietin (EPO) and coagulation factor IX (FIX) demonstrate potent pharmacodynamic effects in the KO mouse model[2].
| Animal Model: | Hemophilia B (FIX knockout (KO)) mouse model[2] |
| Dosage: | 0.25 or 0.5 mg/kg |
| Administration: | Intravenous injection (i.v.), single injection |
| Result: | led to plasma FIX levels of 400 ng/ml and 1.77 μg/ml with doses of 0.25 and 0.50 mg/kg, respectively, in KO mice. And C12-200 resulted in a significant increase in activity in the treated mice. |
References
[1] Khare P, et al. Development of Lipidoid Nanoparticles for siRNA Delivery to Neural Cells. AAPS J. 2021;24(1):8. Published 2021 Dec 6. DOI:10.1208/s12248-021-00653-2
[2] DeRosa F, et al. Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system. Gene Ther. 2016;23(10):699-707. DOI:10.1038/gt.2016.46
[3] Kauffman KJ, et al. Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs. Nano Lett. 2015 Nov 11;15(11):7300-6. DOI:10.1021/acs.nanolett.5b02497
C12-200 Preparation Products And Raw materials
Raw materials
Preparation Products
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