ChemicalBook > CAS DataBase List > (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME

(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME

Product Name: (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME
CAS No.: 667463-85-6
Chemical Name: (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME
Synonyms: CS-1611;BIO-ACETOXIME;GSK-3 INHIBITOR X;GSK3 Inhibitor IX2;BIA|||GSK-3 Inhibitor X;BIO-acetoxime (Synonyms:);6-Bromoindirubin acetoxime;BIO-Acetoxime >=98% (HPLC);BIO-acetoxime, 10 mM in DMSO;6-Bromoindirubin-3′-acetoxime
CBNumber: CB8818870
Molecular Formula: C18H12BrN3O3
Formula Weight: 398.21
MOL File: 667463-85-6.mol

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(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Property

Density: 1.69±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: H2O: soluble2mg/mL (clear solution, warmed)
form: powder
pka: 9.22±0.20(Predicted)
color: dark red to purple
Water Solubility: H2O: 2mg/mL (clear solution, warmed)

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50/53
Safety Statements: 60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0531
Product name: BIO-Acetoxime
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $167.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0531
Product name: BIO-Acetoxime
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $674
Updated: 2025/07/31

Tocris

Product number: 3874
Product name: BIO-acetoxime
Purity: ≥98%(HPLC)
Packaging: 1
Price: $148
Updated: 2021/12/16

Tocris

Product number: 3874
Product name: BIO-acetoxime
Purity: ≥98%(HPLC)
Packaging: 10
Price: $308
Updated: 2021/12/16

TRC

Product number: B591760
Product name: BIO-acetoxime
Packaging: 1mg
Price: $55
Updated: 2021/12/16

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(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Chemical Properties,Usage,Production

Uses

BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. It also induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Biological Activity

Selective GSK-3 α / β inhibitor (IC 50 values are 0.01, 2.4, 4.3 and 63 μ M for GSK-3 α / β , CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

in vivo

BIO-acetoxime (BIA) shows anticonvulsant effects in the focal pilocarpine rat model at 0.5 mg/kg, and in 6-Hz fully kindled FVB/N mice at 0.5, 2.5, and 5 mg/kg via i.p. administration^[3].

IC 50

HSV-1; GSK-3α: 10 nM (IC₅₀); GSK-3β: 10 nM (IC₅₀); CDK5/p35: 2.4 μM (IC₅₀); CDK2/cyclin A: 4.3 μM (IC₅₀); CDK1/cyclin B: 63 μM (IC₅₀)

storage

Store at +4°C

(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Preparation Products And Raw materials

Raw materials

Preparation Products

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(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Suppliers

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View Lastest Price from (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME manufacturers

Career Henan Chemical Co

Product: (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME 667463-85-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95--99%
Supply Ability: 1ton
Release date: 2020-01-03

667463-85-6, (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIMERelated Search:

(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME

BIO-ACETOXIME

GSK-3 INHIBITOR X

(3Z)-3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-Indol-2-one

6-Bromoindirubin acetoxime

6-Bromoindirubin-3′-acetoxime

GSK3 Inhibitor IX2

BIO-acetoxime(GSK-3 Inhibitor)

(2Z,3E)-3-(Acetoxyimino)-6'-bromo-[2,3'-biindolinylidene]-2'-one

BIO-acetoxime GSK3 Inhibitor IX2

CS-1611

GSK3 INHIBITOR X6-BROMOINDIRUBIN-3'-ACETOXIME

BIO-acetoxime (GSK-3 Inhibitor X)

2H-Indol-2-one, 3-[(3E)-3-[(acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-, (3Z)-

BIO-Acetoxime >=98% (HPLC)

BIA|||GSK-3 Inhibitor X

BIO-acetoxime, GSK-3alpha/beta inhibitor

BIO-acetoxime, 10 mM in DMSO

BIO-acetoxime (Synonyms:)

667463-85-6

Other enzyme inhibitors and activators