ChemicalBook > CAS DataBase List > SR 3677 dihydrochloride
SR 3677 dihydrochloride
- Product Name
- SR 3677 dihydrochloride
- CAS No.
- 1781628-88-3
- Chemical Name
- SR 3677 dihydrochloride
- CBNumber
- CB88202846
- Molecular Formula
- C22H25ClN4O4
- Formula Weight
- 444.92
- MOL File
- 1781628-88-3.mol
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SR 3677 dihydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
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SR 3677 dihydrochloride Chemical Properties,Usage,Production
Uses
SR-3677 dihydrochloride (compound 5) is a potent and selective ROCK-I and ROCK-II inhibitor with an IC50 values of 56 nM and 3 nM[1].
IC 50
ROCK-I: 56 nM (IC50); ROCK-II: 3 nM (IC50)
storage
Desiccate at RT
References
[1] Feng Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51(21):6642-5. DOI:10.1021/jm800986w
SR 3677 dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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1781628-88-3, SR 3677 dihydrochlorideRelated Search:
SR-95531
N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide