TERT-BUTYL (4-NITROBENZYL)CARBAMATE

Product Name: TERT-BUTYL (4-NITROBENZYL)CARBAMATE
CAS No.: 94838-58-1
Chemical Name: TERT-BUTYL (4-NITROBENZYL)CARBAMATE
Synonyms: N-Boc-4-nitrobenzylamine;TERT-BUTYL (4-NITROBENZYL)CARBAMATE;2-Methyl-2-propanyl (4-nitrobenzyl)carbamate;tert-butyl N-[(4-nitrophenyl)methyl]carbamate;Carbamic acid, N-[(4-nitrophenyl)methyl]-, 1,1-dimethylethyl ester
CBNumber: CB8835552
Molecular Formula: C12H16N2O4
Formula Weight: 252.27
MOL File: 94838-58-1.mol

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TERT-BUTYL (4-NITROBENZYL)CARBAMATE Property

Melting point:: 105-108 °C
Boiling point:: 408.8±28.0 °C(Predicted)
Density: 1.187±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 11.58±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 8824CR
Product name: Tert-Butyl4-nitrobenzylcarbamate
Packaging: 1g
Price: $195
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0371106
Product name: TERT-BUTYL-(4-NITROBENZYL)CARBAMATE
Purity: 95.00%
Packaging: 5MG
Price: $496.58
Updated: 2021/12/16

Alichem

Product number: 94838581
Product name: tert-Butyl(4-nitrobenzyl)carbamate
Packaging: 10g
Price: $510.34
Updated: 2021/12/16

Crysdot

Product number: CD12003166
Product name: tert-Butyl4-nitrobenzylcarbamate
Purity: 95+%
Packaging: 5g
Price: $221
Updated: 2021/12/16

Acrotein

Product number: AM-5193
Product name: N-Boc-4-nitrobenzylamine
Purity: 97%
Packaging: 1g
Price: $110
Updated: 2021/12/16

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TERT-BUTYL (4-NITROBENZYL)CARBAMATE Chemical Properties,Usage,Production

Synthesis

24424-99-5

18600-42-5

94838-58-1

Step 1: Preparation of tert-butyl 4-nitrobenzylcarbamate (C4) 4-Nitrobenzylamine hydrochloride (10 g, 53.0 mmol) was suspended in a mixed solvent of THF (150 mL) and water (13 mL) and cooled to 0 °C. Di-tert-butyl dicarbonate (11.6 g, 53.0 mmol) and N,N-diisopropylethylamine (27.7 mL, 159 mmol) were added sequentially under stirring. The reaction mixture was stirred at 0 °C for 30 min and then slowly warmed up to 25 °C and continued stirring for about 20 hours. Upon completion of the reaction, most of the THF was removed by concentration under reduced pressure. the residue was dissolved in EtOAc and washed sequentially with 1N HCl, saturated NaHCO3 solution and saturated NaCl solution. The organic phase was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure to give the off-white solid product C4 (14.0 g, 99% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.16 (d, 2H), 7.55 (t, 1H), 7.46 (d, 2H), 4.21 (d, 2H), 1.36 (s, 9H).

References

[1] Patent: US2009/54395, 2009, A1. Location in patent: Page/Page column 48
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 24, p. 4389 - 4393
[3] European Journal of Medicinal Chemistry, 2014, vol. 80, p. 101 - 111
[4] Chemical Communications, 2014, vol. 50, # 97, p. 15305 - 15308
[5] Patent: US2016/264520, 2016, A1. Location in patent: Paragraph 0332; 0333; 0334; 0335

TERT-BUTYL (4-NITROBENZYL)CARBAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL (4-NITROBENZYL)CARBAMATE Suppliers

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94838-58-1, TERT-BUTYL (4-NITROBENZYL)CARBAMATERelated Search:

TERT-BUTYL (4-NITROBENZYL)CARBAMATE (2R)-[(tert-butoxycarbonyl)amino](4-nitrophenyl)ethanoic acid TERT-BUTOXYCARBONYLAMINO-(4-NITRO-PHENYL)-ACETIC ACID BOC-(S)-3-AMINO-3-(4-NITRO-PHENYL)-PROPIONIC ACID BOC-2,4-DINITRO-DL-PHENYLGLYCINE N,N-DI-T-BOC-(2-FLUORO-4-NITROPHENYL)METHANAMINE (R)-3-BOC-AMINO-3-(4-NITROPHENYL)PROPIONIC ACID 3-TERT-BUTOXYCARBONYLAMINO-3-(4-NITRO-PHENYL)-PROPIONIC ACID methyl (2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-(4-nitrophenyl)propanoate TERT-BUTYL 4-(4-NITROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)-CARBOXYLATE

TERT-BUTYL (4-NITROBENZYL)CARBAMATE

tert-butyl N-[(4-nitrophenyl)methyl]carbamate

N-Boc-4-nitrobenzylamine

Carbamic acid, N-[(4-nitrophenyl)methyl]-, 1,1-dimethylethyl ester

2-Methyl-2-propanyl (4-nitrobenzyl)carbamate

94838-58-1