Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]-

Product Name: Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]-
CAS No.: 2225836-30-4
Chemical Name: Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]-
Synonyms: ACH-000143;ACH-000143, 10 mM in DMSO;Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]-;N-[2-(5-chloro-2,6-dimethoxy-1H-1,3-benzodiazol-1-yl)ethyl]acetamide;N-(2-(5-chloro-2,6-dimethoxy-1H-benzo[d]imidazol-1-yl)ethyl)acetamide;Melatonin Receptor,HFD,toxicity,low,steatosis,Inhibitor,ACH-000143,inhibit,ACH 000143,obese,ACH000143
CBNumber: CB88376516
Molecular Formula: C13H16ClN3O3
Formula Weight: 297.74
MOL File: 2225836-30-4.mol

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Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]- Property

Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 50 mg/mL (167.93 mM; Need ultrasonic)
form: Solid
pka: 15.77±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0159650
Product name: ACH-000143
Packaging: 5mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0159650
Product name: ACH-000143
Packaging: 10mg
Price: $480
Updated: 2021/12/16

ChemScene

Product number: CS-0159650
Product name: ACH-000143
Packaging: 25mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0159650
Product name: ACH-000143
Packaging: 50mg
Price: $1450
Updated: 2021/12/16

ChemScene

Product number: CS-0159650
Product name: ACH-000143
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

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Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]- Chemical Properties,Usage,Production

Biological Activity

ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively[1]. ACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats[1].ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate[1].ACH-000143 significantly reduces plasma glucose at 10 mg/kg (-16.4%, p < 0.05) and 30 mg/kg (-16.9%, p < 0.01)[1].

References

[1]. Marcos Antonio Ferreira Jr, et al. Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats. J Med Chem. 2021 Feb 25;64(4):1904-1929.

Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]- Suppliers

China 22 United States 3 Global 25

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2225836-30-4, Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]-Related Search:

Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]-

ACH-000143

Melatonin Receptor,HFD,toxicity,low,steatosis,Inhibitor,ACH-000143,inhibit,ACH 000143,obese,ACH000143

N-(2-(5-chloro-2,6-dimethoxy-1H-benzo[d]imidazol-1-yl)ethyl)acetamide

N-[2-(5-chloro-2,6-dimethoxy-1H-1,3-benzodiazol-1-yl)ethyl]acetamide

ACH-000143, 10 mM in DMSO

2225836-30-4