Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]-
- Product Name
- Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]-
- CAS No.
- 2225836-30-4
- Chemical Name
- Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]-
- Synonyms
- ACH-000143;ACH-000143, 10 mM in DMSO;Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]-;N-[2-(5-chloro-2,6-dimethoxy-1H-1,3-benzodiazol-1-yl)ethyl]acetamide;N-(2-(5-chloro-2,6-dimethoxy-1H-benzo[d]imidazol-1-yl)ethyl)acetamide;Melatonin Receptor,HFD,toxicity,low,steatosis,Inhibitor,ACH-000143,inhibit,ACH 000143,obese,ACH000143
- CBNumber
- CB88376516
- Molecular Formula
- C13H16ClN3O3
- Formula Weight
- 297.74
- MOL File
- 2225836-30-4.mol
Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]- Property
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO : 50 mg/mL (167.93 mM; Need ultrasonic)
- form
- Solid
- pka
- 15.77±0.46(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-0159650
- Product name
- ACH-000143
- Packaging
- 5mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- CS-0159650
- Product name
- ACH-000143
- Packaging
- 10mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- CS-0159650
- Product name
- ACH-000143
- Packaging
- 25mg
- Price
- $950
- Updated
- 2021/12/16
- Product number
- CS-0159650
- Product name
- ACH-000143
- Packaging
- 50mg
- Price
- $1450
- Updated
- 2021/12/16
- Product number
- CS-0159650
- Product name
- ACH-000143
- Packaging
- 100mg
- Price
- $2250
- Updated
- 2021/12/16
Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]- Chemical Properties,Usage,Production
Biological Activity
ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively[1]. ACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats[1].ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate[1].ACH-000143 significantly reduces plasma glucose at 10 mg/kg (-16.4%, p < 0.05) and 30 mg/kg (-16.9%, p < 0.01)[1].
References
[1]. Marcos Antonio Ferreira Jr, et al. Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats. J Med Chem. 2021 Feb 25;64(4):1904-1929.
Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]- Suppliers
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