D-ERYTHRO-C20-DIHYDROSPHINGOSINE

Product Name: D-ERYTHRO-C20-DIHYDROSPHINGOSINE
CAS No.: 24006-62-0
Chemical Name: D-ERYTHRO-C20-DIHYDROSPHINGOSINE
Synonyms: Sphinganine-C20;C20 sphinganine;Sphinganine (d20:0);D-erythro-sphinganine (C20 base);D-ERYTHRO-C20-DIHYDROSPHINGOSINE;D-ERYTHRO-SPHINGANINE, C20 CHAIN;1,3-Eicosanediol, 2-amino-, (2S,3R)-;D-ERYTHRO-SPHINGANINE (C20 BASE);SPHINGANINE (D20:0);D-erythro-C20-Dihydrosphingosine, Ceramide biosynthesis intermediate
CBNumber: CB8839323
Molecular Formula: C20H43NO2
Formula Weight: 329.56
MOL File: 24006-62-0.mol

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D-ERYTHRO-C20-DIHYDROSPHINGOSINE Property

Boiling point:: 471.9±25.0 °C(Predicted)
Density: 0.920±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Chloroform:Methanol (5:1): soluble; Ethanol: soluble, warmed
form: A solid
pka: 12.57±0.45(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22509
Product name: Sphinganine (d20:0)
Purity: ≥98%
Packaging: 1mg
Price: $64
Updated: 2024/03/01

Cayman Chemical

Product number: 22509
Product name: Sphinganine (d20:0)
Purity: ≥98%
Packaging: 5mg
Price: $251
Updated: 2024/03/01

TRC

Product number: S680675
Product name: Sphinganine-C20
Packaging: 1mg
Price: $160
Updated: 2021/12/16

TRC

Product number: S680675
Product name: Sphinganine-C20
Packaging: 10mg
Price: $1260
Updated: 2021/12/16

AK Scientific

Product number: 9403CS
Product name: Eicosasphinganine
Packaging: 1mg
Price: $187
Updated: 2021/12/16

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D-ERYTHRO-C20-DIHYDROSPHINGOSINE Chemical Properties,Usage,Production

Description

Sphinganine (d20:0) is a natural isomer of dihydro-D-erythro-sphinganine (sphinganine (d18:0); ) that is a precursor of ceramide and sphingosine as well as a substrate for sphingosine kinases, which generate sphingosine-1-phosphate (d18:1) . In S. cerevisiae, the amount of sphinganine (d20:0) increases 10.8-fold in response to heat stress, indicating it is involved in heat stress adaptation. Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins as well as in some cancers. Sphinganine can block protein kinase C activation in some cases but not others. [Matreya, LLC. Catalog No. 1845]

Uses

Sphinganine-C20 is a sphingolipid that plays an important role in the regulation of central cellular processes, including cell growth, survival and differentiation.

Definition

ChEBI: A 2-aminoicosane-1,3-diol having (2S,3R)-configuration.

References

[1] G M JENKINS. Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae.[J]. The Journal of Biological Chemistry, 1997, 272 51: 32566-32572. DOI: 10.1074/jbc.272.51.32566
[2] JUN YIN . Altered sphingolipid metabolism induced by tumor hypoxia – New vistas in glycolipid tumor markers[J]. FEBS Letters, 2010, 584 9: Pages 1872-1878. DOI: 10.1016/j.febslet.2009.11.019
[3] SARAH T PRUETT. Biodiversity of sphingoid bases (“sphingosines”) and related amino alcohols.[J]. Journal of Lipid Research, 2008, 49 8: 1621-1639. DOI: 10.1194/jlr.r800012-jlr200
[4] G S SHEPHARD V S L Van Der Westhuizen. Biomarkers of exposure to fumonisin mycotoxins: a review.[J]. Food additives and contaminants, 2007, 24 10: 1196-1201. DOI: 10.1080/02652030701513818
[5] A. MERRILL. Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases.[J]. The Journal of Biological Chemistry, 1986, 1 1: 12610-12615. DOI: 10.1016/s0021-9258(18)67134-0
[6] JR. A H M. Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds[J]. Biochemistry Biochemistry, 1989, 28 8: 3138-3145. DOI: 10.1021/bi00434a004

D-ERYTHRO-C20-DIHYDROSPHINGOSINE Preparation Products And Raw materials

Raw materials

Preparation Products

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D-ERYTHRO-C20-DIHYDROSPHINGOSINE Suppliers

China 36 India 1 United States 8 Global 45

Shanghai Aladdin Bio-Chem Technology Co.,LTD

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Energy Chemical

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24006-62-0, D-ERYTHRO-C20-DIHYDROSPHINGOSINERelated Search:

D-erythro-sphinganine (C17 base) D-ERYTHRO-C20-DIHYDROSPHINGOSINE

D-ERYTHRO-SPHINGANINE, C20 CHAIN

D-ERYTHRO-C20-DIHYDROSPHINGOSINE

D-erythro-sphinganine (C20 base)

D-ERYTHRO-SPHINGANINE (C20 BASE);SPHINGANINE (D20:0)

Sphinganine (d20:0)

C20 sphinganine

Sphinganine-C20

1,3-Eicosanediol, 2-amino-, (2S,3R)-

D-erythro-C20-Dihydrosphingosine, Ceramide biosynthesis intermediate

24006-62-0