ChemicalBook > CAS DataBase List > 1-(1-METHYL-1H-IMIDAZOL-2-YL)-ETHANONE

1-(1-METHYL-1H-IMIDAZOL-2-YL)-ETHANONE

Product Name
1-(1-METHYL-1H-IMIDAZOL-2-YL)-ETHANONE
CAS No.
85692-37-1
Chemical Name
1-(1-METHYL-1H-IMIDAZOL-2-YL)-ETHANONE
Synonyms
1-Methyl-2-acetylimidazole;2-Acetyl-1-MethyliMidazole;2-Acetyl-1-MethyliMidazol...;1-(1-Methyl-1H-imidazol-2-yl);1-(1-methylimidazol-2-yl)ethanone;1-(1-methyl-2-imidazolyl)ethanone;1-(1-METHYL-1H-IMIDAZOL-2-YL)-ETHANONE;1-(1-Methyl-1H-iMidazol-2-yl)ethan-1-one;ethanone, 1-(1-methyl-1H-imidazol-2-yl)-;Ethanone, 1-(1-methyl-1H-imidazol-2-yl)- (9CI)
CBNumber
CB8841986
Molecular Formula
C6H8N2O
Formula Weight
124.14
MOL File
85692-37-1.mol
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1-(1-METHYL-1H-IMIDAZOL-2-YL)-ETHANONE Property

Boiling point:
105℃ (15 Torr)
Density 
1.11±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Oil
pka
3.92±0.25(Predicted)
color 
Brown
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Safety

HazardClass 
IRRITANT
HS Code 
2933299090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M313573
Product name
1-(1-Methyl-1H-imidazol-2-yl)ethanone
Packaging
100mg
Price
$70
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-NW
Product name
2-Acetyl-1-methylimidazole
Packaging
250mg
Price
$100
Updated
2021/12/16
AK Scientific
Product number
3329AC
Product name
1-(1-Methyl-1H-imidazol-2-yl)ethanone
Packaging
100mg
Price
$132
Updated
2021/12/16
Apolloscientific
Product number
OR928251
Product name
1-(1-Methyl-1H-imidazol-2-yl)ethan-1-one
Purity
95%
Packaging
250mg
Price
$150
Updated
2021/12/16
AK Scientific
Product number
3329AC
Product name
1-(1-Methyl-1H-imidazol-2-yl)ethanone
Packaging
250mg
Price
$165
Updated
2021/12/16
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1-(1-METHYL-1H-IMIDAZOL-2-YL)-ETHANONE Chemical Properties,Usage,Production

Uses

1-(1-Methyl-1H-imidazol-2-yl)ethanone can be used for extensive ligand screening and mechanistic studies.

Synthesis

To a mixture of 1-(1-imidazol-2-yl)ethan-1-one 13 (75 mg, 0.68 mmol, 1.0 eq.) and potassium carbonate (235 mg, 1.7 mmol, 2.5 eq.) was added methyl iodide (47 L, 0.7 mmol, 1.1 eq.) and anhydrous acetonitrile (1.0 mL) under nitrogen. The reaction mixture was stirred at room temperature overnight and monitored by TLC (1.0% methanol/DCM). Acetonitrile was removed on a rotary evaporator and the residue was treated with water (5.0 mL) and extracted with DCM (3 x 5.0 mL). The combined organic extracts were dried with anhydrous sodium sulfate and concentrated on a rotary evaporator to give a brown oil. This was chromatographically separated on silica gel in 0.5-1 methanol/DCM to give 1-(1-methyl-1H-imidazol-2-yl)ethanone as a clarified oil (22 mg, 26%).

1-(1-METHYL-1H-IMIDAZOL-2-YL)-ETHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(1-METHYL-1H-IMIDAZOL-2-YL)-ETHANONE Suppliers

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