4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE

Product Name: 4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE
CAS No.: 191034-25-0
Chemical Name: 4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE
Synonyms: 049;L-168;L-168,049;4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE;Pyridine, 4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]-
CBNumber: CB8842589
Molecular Formula: C24H20BrClN2O
Formula Weight: 467.79
MOL File: 191034-25-0.mol

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4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE Property

Boiling point:: 542.3±50.0 °C(Predicted)
Density: 1.367±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
form: Light beige solid
pka: 13.99±0.50(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 346003
Product name: Glucagon Receptor Antagonist II - CAS 191034-25-0 - Calbiochem<br />The Glucagon Receptor Antagonist II, also referenced under CAS 191034-25-0, controls the biological activity of Glucagon Receptor.
Packaging: 5mg
Price: $216
Updated: 2024/03/01

Tocris

Product number: 2311
Product name: L-168,049
Purity: ≥99%(HPLC)
Packaging: 10
Price: $184
Updated: 2021/12/16

Tocris

Product number: 2311
Product name: L-168,049
Purity: ≥99%(HPLC)
Packaging: 50
Price: $774
Updated: 2021/12/16

Usbiological

Product number: 255628
Product name: L-168,049
Packaging: 10mg
Price: $423
Updated: 2021/12/16

TRC

Product number: L210840
Product name: L-168,049
Packaging: 2.5mg
Price: $195
Updated: 2021/12/16

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4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE Chemical Properties,Usage,Production

Uses

L- is a potent (Kb = 25 nM), selective antagonist of glucagon.

Definition

ChEBI: 4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine is a member of pyrroles.

Biological Activity

Very potent and selective, non-competitive antagonist of the human glucagon receptor (hGR). Binds with high affinity to human GR (IC 50 = 3.7 nM), and moderate affinity to murine and canine GRs (IC 50 values are 63 and 60 nM respectively). In contrast, displays poor affinity for rat, guinea pig, and rabbit glucagon receptors (IC 50 > 1 μ M). In functional studies, inhibits glucagon-stimulated cAMP synthesis in CHO cells expressing hGR (IC 50 = 41 nM), and in murine liver membranes. Orally active in vivo .

storage

Store at RT

4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE Suppliers

China 16 Germany 3 United Kingdom 1 United States 5 Global 25

3B Pharmachem (Wuhan) International Co.,Ltd.

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TargetMol Chemicals Inc.

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Changzhou Chenhong Biotechnology Co., Ltd.

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Shanghai Universal Biotech Co.,Ltd

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191034-25-0, 4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINERelated Search:

2,4-Diphenylpyrrole 4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE

4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE

L-168,049

Pyridine, 4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]-

049

L-168

191034-25-0

C24H20BrClN2O

Glucagon receptor and related