4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE

Product Name: 4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE
CAS No.: 191034-25-0
Chemical Name: 4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE
Synonyms: 049;L-168;L-168,049;L-168049, 10 mM in DMSO;Glucagon Receptor Antagonist II;4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE;Pyridine, 4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]-
CBNumber: CB8842589
Molecular Formula: C24H20BrClN2O
Formula Weight: 467.79
MOL File: 191034-25-0.mol

More

Less

4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE Property

Boiling point:: 542.3±50.0 °C(Predicted)
Density: 1.367±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
form: Light beige solid
pka: 13.99±0.50(Predicted)
color: Light yellow to yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 346003
Product name: Glucagon Receptor Antagonist II - CAS 191034-25-0 - Calbiochem<br />The Glucagon Receptor Antagonist II, also referenced under CAS 191034-25-0, controls the biological activity of Glucagon Receptor.
Packaging: 5mg
Price: $189
Updated: 2025/07/31

Tocris

Product number: 2311
Product name: L-168,049
Purity: ≥99%(HPLC)
Packaging: 10
Price: $184
Updated: 2021/12/16

Tocris

Product number: 2311
Product name: L-168,049
Purity: ≥99%(HPLC)
Packaging: 50
Price: $774
Updated: 2021/12/16

TRC

Product number: L210840
Product name: L-168,049
Packaging: 2.5mg
Price: $195
Updated: 2021/12/16

Usbiological

Product number: 255628
Product name: L-168,049
Packaging: 10mg
Price: $423
Updated: 2021/12/16

More

Less

4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE Chemical Properties,Usage,Production

Uses

L- is a potent (Kb = 25 nM), selective antagonist of glucagon.

Definition

ChEBI: 4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine is a member of pyrroles.

Biological Activity

Very potent and selective, non-competitive antagonist of the human glucagon receptor (hGR). Binds with high affinity to human GR (IC 50 = 3.7 nM), and moderate affinity to murine and canine GRs (IC 50 values are 63 and 60 nM respectively). In contrast, displays poor affinity for rat, guinea pig, and rabbit glucagon receptors (IC 50 > 1 μ M). In functional studies, inhibits glucagon-stimulated cAMP synthesis in CHO cells expressing hGR (IC 50 = 41 nM), and in murine liver membranes. Orally active in vivo .

in vivo

In the liver of L-G6pc^/- mice, Pck1 mRNA expression is decreased by half 6 h after the administration of L-168049 (50 mg/kg body; p.o.), demonstrating the efficiency of the suppression of glucagon signaling. In agreement with the role of glucagon in the induction of extrahepatic gluconeogenesis, the administration of the L-168049 prevents the increase of the G6pc expression in both the kidneys and intestine of 6 h-fasted L-G6pc^/- mice^[3].

storage

Store at RT

4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE Suppliers

China 33 Germany 3 United Kingdom 1 United States 5 Global 42

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD

Tel: 13816107857
Fax: qq: 276312098
Email: sales@fortunechem-sh.com
Country: China
ProdList: 984
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2991
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Shanghai Changyu Medical Technology Co. Ltd.

Tel: +86-13301875428
Email: sales@changyuhe.com
Country: China
ProdList: 311
Advantage: 58

191034-25-0, 4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINERelated Search:

2,4-Diphenylpyrrole 4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE

4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE

L-168,049

Pyridine, 4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]-

049

L-168

L-168049, 10 mM in DMSO

Glucagon Receptor Antagonist II

191034-25-0

C24H20BrClN2O

Glucagon receptor and related