ChemicalBook > CAS DataBase List > 10,10-BIS[(2-FLUORO-4-PYRIDINYL)METHYL]-9(10H)-ANTHRACENONE

10,10-BIS[(2-FLUORO-4-PYRIDINYL)METHYL]-9(10H)-ANTHRACENONE

Product Name: 10,10-BIS[(2-FLUORO-4-PYRIDINYL)METHYL]-9(10H)-ANTHRACENONE
CAS No.: 160588-45-4
Chemical Name: 10,10-BIS[(2-FLUORO-4-PYRIDINYL)METHYL]-9(10H)-ANTHRACENONE
Synonyms: XR 543;DMP 543;DMP 543,DMP543;DMP 543 (XR-543;DMP-543, 10 mM in DMSO;10,10-BIS[(2-FLUORO-4-PYRIDYL)METHYL]ANTHRONE;10,10-BIS[(2-FLUORO-4-PYRIDINYL)METHYL]-9(10H)-ANTHRACENONE;10,10-Bis((2-fluoropyridin-4-yl)Methyl)anthracen-9(10H)-one;9(10H)-Anthracenone, 10,10-bis[(2-fluoro-4-pyridinyl)methyl]-;10,10-bis[(2-fluoropyridin-4-yl)methyl]-9,10-dihydroanthracen-9-one
CBNumber: CB8843647
Molecular Formula: C26H18F2N2O
Formula Weight: 412.43
MOL File: 160588-45-4.mol

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10,10-BIS[(2-FLUORO-4-PYRIDINYL)METHYL]-9(10H)-ANTHRACENONE Property

Melting point:: 159-161 °C
Boiling point:: 593.1±50.0 °C(Predicted)
Density: 1.319±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: Soluble to 100 mM in DMSO and to 50 mM in ethanol
form: Powder
pka: 0.38±0.10(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2330
Product name: DMP543
Purity: ≥99%(HPLC)
Packaging: 10
Price: $136
Updated: 2021/12/16

Tocris

Product number: 2330
Product name: DMP543
Purity: ≥99%(HPLC)
Packaging: 50
Price: $556
Updated: 2021/12/16

Usbiological

Product number: 255174
Product name: DMP 543
Packaging: 10mg
Price: $423
Updated: 2021/12/16

ChemScene

Product number: CS-0029261
Product name: DMP-543
Purity: 99.96%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-0029261
Product name: DMP-543
Purity: 99.96%
Packaging: 10mg
Price: $130
Updated: 2021/12/16

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10,10-BIS[(2-FLUORO-4-PYRIDINYL)METHYL]-9(10H)-ANTHRACENONE Chemical Properties,Usage,Production

Uses

DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer[1][2].

Definition

ChEBI: 10,10-bis[(2-fluoro-4-pyridinyl)methyl]-9-anthracenone is a member of anthracenes.

References

[1] Ipavec V, et al. KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus. Pharmacol Res. 2011 Oct;64(4):397-409. DOI:10.1016/j.phrs.2011.06.016
[2] Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30. PMID:9580619

10,10-BIS[(2-FLUORO-4-PYRIDINYL)METHYL]-9(10H)-ANTHRACENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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160588-45-4, 10,10-BIS[(2-FLUORO-4-PYRIDINYL)METHYL]-9(10H)-ANTHRACENONERelated Search:

5-Fluorouracil 2-Chloro-5-trifluoromethylpyridine DI-2-PYRIDYL KETONE 4-Isopropylpyridine Anthrone 4-phenethylpyridine 4-ISOBUTYL-PYRIDINE 2-Fluoro-4-methylpyridine 10,10-Dimethylanthrone 4,4'-Trimethylenedipyridine 10,10-BIS[(2-FLUORO-4-PYRIDINYL)METHYL]-9(10H)-ANTHRACENONE

DMP 543 (XR-543

XR 543

10,10-BIS[(2-FLUORO-4-PYRIDINYL)METHYL]-9(10H)-ANTHRACENONE

DMP 543

10,10-BIS[(2-FLUORO-4-PYRIDYL)METHYL]ANTHRONE

10,10-Bis((2-fluoropyridin-4-yl)Methyl)anthracen-9(10H)-one

9(10H)-Anthracenone, 10,10-bis[(2-fluoro-4-pyridinyl)methyl]-

DMP 543,DMP543

10,10-bis[(2-fluoropyridin-4-yl)methyl]-9,10-dihydroanthracen-9-one

DMP-543, 10 mM in DMSO

160588-45-4

C26H18F2N2O

Potassium channel