4-CHLORO-8-NITROQUINOLINE

Product Name: 4-CHLORO-8-NITROQUINOLINE
CAS No.: 23833-99-0
Chemical Name: 4-CHLORO-8-NITROQUINOLINE
Synonyms: 4-CHLORO-8-NITROQUINOLINE;Quinoline, 4-chloro-8-nitro-
CBNumber: CB8846648
Molecular Formula: C9H5ClN2O2
Formula Weight: 208.6
MOL File: 23833-99-0.mol

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4-CHLORO-8-NITROQUINOLINE Property

Melting point:: 127-128 °C
Boiling point:: 339.9±27.0 °C(Predicted)
Density: 1.484±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.22±0.30(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C612260
Product name: 4-chloro-8-nitroquinoline
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC133242
Product name: 4-Chloro-8-nitroquinoline
Packaging: 250mg
Price: $85
Updated: 2021/12/16

AK Scientific

Product number: 1662AB
Product name: 4-Chloro-8-nitroquinoline
Packaging: 1g
Price: $122
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC133242
Product name: 4-Chloro-8-nitroquinoline
Packaging: 500mg
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC133242
Product name: 4-Chloro-8-nitroquinoline
Packaging: 1g
Price: $255
Updated: 2021/12/16

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4-CHLORO-8-NITROQUINOLINE Chemical Properties,Usage,Production

Synthesis

611-35-8

23833-99-0

4-Chloro-8-nitroquinoline (6a) was synthesized as follows: 4-chloroquinoline (10.0 g, 61.3 mmol) was slowly added to sulfuric acid (45 mL), and the temperature needed to be controlled not to exceed 15 °C during the reaction. Subsequently, the reaction solution was cooled to -15 °C and fuming nitric acid was added dropwise at this temperature. After addition, the reaction mixture was gradually warmed to room temperature and stirring was continued for 3 hours. Upon completion of the reaction, the mixture was poured onto ice, the pH was adjusted to 9 with NH4OH, the precipitated solid precipitate was collected by filtration, washed thoroughly with water, dried and recrystallized from methanol to afford the target product 4-chloro-8-nitroquinoline (6a) 7.5 g in 59% yield. The product characterization data were as follows: melting point 128-129 °C (literature value 129-130 °C); 1H NMR (CDCl3) δ 7.67 (d, 1H, J=4.5 Hz), 7.75 (dd, 1H, J=8.6 Hz, J=7.6 Hz), 8.10 (dd, 1H, J=7.6 Hz, J=1.3 Hz), 8.48 (dd. 1H, J=8.6Hz, J=1.3Hz), 8.94 (d, 1H, J=4.5Hz); 13C NMR (CDCl3) δ 123.0, 124.4, 126.5, 127.5, 128.3, 140.6, 143.2, 148.7, 152.1.

References

[1] Chemical and Pharmaceutical Bulletin, 2013, vol. 61, # 7, p. 747 - 756
[2] Patent: WO2004/14906, 2004, A2. Location in patent: Page 19
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 13, p. 3517 - 3520
[4] Journal of Enzyme Inhibition and Medicinal Chemistry, 2015, vol. 30, # 4, p. 607 - 614
[5] Patent: US2010/249182, 2010, A1. Location in patent: Page/Page column 3; 5

4-CHLORO-8-NITROQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-CHLORO-8-NITROQUINOLINE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Chloro-8-nitroquinoline 23833-99-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-15

23833-99-0, 4-CHLORO-8-NITROQUINOLINERelated Search:

4-CHLORO-8-NITRO-QUINOLINE-3-CARBONITRILE 4-CHLORO-8-NITROQUINOLINE 8-Nitroquinoline

4-CHLORO-8-NITROQUINOLINE

Quinoline, 4-chloro-8-nitro-

23833-99-0