BACMECILLINAM Property

Boiling point:

256°C (rough estimate)

Density 

1.2025 (rough estimate)

refractive index 

1.6390 (estimate)

color 

Oil

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36

Hazard and Precautionary Statements (GHS)

BACMECILLINAM Chemical Properties,Usage,Production

Originator

Bacmecillinam,ZYF Pharm Chemical

Manufacturing Process

1-Hexamethyleneiminocarboxaldehyde dimethylacetate (3.1 g) in chloroform (50 ml) was added dropwise at -30°C to a solution of 1’- ethoxycarbonyloxyethyl 6-aminopenicillanate (5.0 g) and triethylamine (1.9 ml) in chloroform (150 ml) during 15 min. Then, the temperature is allowed to rise to 0°C during 30 min, and the mixture is stirred at 0°C for another 60 min. Water (120 ml) is added, and stirring is continued for 10 min. The water phase is separated and the organic layer is washed with water and stripped. There was obtained 5.0 g of the 1’-ethoxycarbonyloxy-ethyl 6-(hexahydro-1Hazepin- l-yl) methyleneaminopenicillanate.

Therapeutic Function

Antibiotic

Safety Profile

An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of SOx and NOx.