2-AMINO-4-BROMOQUINOLINE
- Product Name
- 2-AMINO-4-BROMOQUINOLINE
- CAS No.
- 36825-32-8
- Chemical Name
- 2-AMINO-4-BROMOQUINOLINE
- Synonyms
- 4-Bromoquinolin-2-amine;4-Bromo-2-quinolinamine;2-AMINO-4-BROMOQUINOLINE;2-Quinolinamine, 4-bromo-;2-Amino-4-bromoquinoline 97%;4-Bromoquinolin-2-amine, 2-Amino-4-bromo-1-azanaphthalene
- CBNumber
- CB8847397
- Molecular Formula
- C9H7BrN2
- Formula Weight
- 223.07
- MOL File
- 36825-32-8.mol
2-AMINO-4-BROMOQUINOLINE Property
- Melting point:
- 137-138℃
- Boiling point:
- 359℃
- Density
- 1.649
- Flash point:
- 171℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 5.01±0.50(Predicted)
- Appearance
- Light yellow to brown Solid
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B292350
- Product name
- 4-bromoquinolin-2-amine
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 1229CV
- Product name
- 4-Bromoquinolin-2-amine
- Packaging
- 100mg
- Price
- $159
- Updated
- 2021/12/16
- Product number
- 3H30-9-59
- Product name
- 2-Amino-4-bromoquinoline
- Packaging
- 100mg
- Price
- $208
- Updated
- 2021/12/16
- Product number
- 1229CV
- Product name
- 4-Bromoquinolin-2-amine
- Packaging
- 250mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 3H30-9-59
- Product name
- 2-Amino-4-bromoquinoline
- Packaging
- 250mg
- Price
- $333
- Updated
- 2021/12/16
2-AMINO-4-BROMOQUINOLINE Chemical Properties,Usage,Production
Synthesis
42712-64-1
36825-32-8
The general procedure for the synthesis of 2-amino-4-bromoquinoline from 2-amino-4-hydroxyquinoline was as follows: 2-aminoquinolin-4-ol (0.7 g, 4.37 mmol) was added to a pressure tube, followed by phosphorus tribromide oxide (2.51 g, 8.74 mmol) and phosphorus tribromide (3 mL, 31.8 mmol). The pressure tube was sealed and the reaction was heated at 150°C for 19 hours under nitrogen protection. Upon completion of the reaction, the reaction mixture was cooled to room temperature, alkalized with 2 M aqueous sodium hydroxide (10 mL) and subsequently extracted with ethyl acetate (3 x 25 mL). The organic layers were combined, washed with water (20 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting solid was washed with hexane (20 mL) to remove non-polar impurities and dried under reduced pressure to give a dark brown residue. This residue was purified by silica gel column chromatography (using a gradient elution of methanol and chloroform) to give 4-bromoquinolin-2-amine (160 mg, 0.71 mmol, 16% yield). LC-MS (ESI) m/z 223.0 (bromine isotope mode) [(M + H)+, calculated value C9H8BrN2, 223.0]; LC-MS retention time (method B): tR = 1.14 min.
References
[1] Patent: WO2015/116492, 2015, A1. Location in patent: Page/Page column 105-106
2-AMINO-4-BROMOQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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