(4-OXO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER
- Product Name
- (4-OXO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER
- CAS No.
- 66405-41-2
- Chemical Name
- (4-OXO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER
- Synonyms
- (4-OXOCYCLOHEXYL)ACETIC ACID;Methyl (4-oxocyclohexyl)acetate;METHYL 2 -(4-OXOCYCLOHEXYL)-ACETATE 97%;(4-OXO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER;Cyclohexaneacetic acid, 4-oxo-, Methyl ester
- CBNumber
- CB8849649
- Molecular Formula
- C9H14O3
- Formula Weight
- 170.21
- MOL File
- 66405-41-2.mol
(4-OXO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2918300090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M223378
- Product name
- Methyl2-(4-Oxocyclohexyl)acetate
- Packaging
- 30mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M223378
- Product name
- Methyl2-(4-Oxocyclohexyl)acetate
- Packaging
- 300mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- CHM0125031
- Product name
- (4-OXO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.42
- Updated
- 2021/12/16
- Product number
- CS-W006286
- Product name
- Methyl2-(4-oxocyclohexyl)acetate
- Packaging
- 5g
- Price
- $535
- Updated
- 2021/12/16
- Product number
- 083630
- Product name
- Methyl (4-oxocyclohexyl)acetate
- Purity
- 95%
- Packaging
- 1g
- Price
- $524
- Updated
- 2021/12/16
(4-OXO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER Chemical Properties,Usage,Production
Synthesis
317338-46-8
66405-41-2
The general procedure for the synthesis of methyl 2-(4-oxocyclohexyl)acetate from methyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)acetate was as follows: methyl 2-(4-(1,3-dioxaspiro[4.5]cyclohexyl)acetate (51.1 g, 238 mmol, 1.0 equiv) was dissolved in tetrahydrofuran (2 L). The solution was cooled to 0 °C and 2N hydrochloric acid (1.4 L, 2.8 mol, 12.0 eq.) was added slowly and dropwise over 2.5 h. The reaction temperature was kept at 0 °C. The reaction mixture was stirred overnight and allowed to warm up naturally to room temperature. Subsequently, water (1 L) and ethyl acetate (1 L) were added to separate the organic and aqueous layers. The aqueous layer was extracted with ethyl acetate (1 L). The organic layers were combined, washed with saturated saline (1 L) and dried with anhydrous sodium sulfate. After evaporation of the solvent under reduced pressure, the product was purified by column chromatography (silica gel: ethyl acetate/heptane=1/4). Methyl 2-(4-oxocyclohexyl)acetate 21.9 g was obtained in 54% yield as a clear oil.1H NMR (CDCl3, 300 MHz) δ 1.50 (m, 2H), 2.16 (m, 2H), 2.36 (d, 2H), 2.38 (m, 1H), 2.39 (m, 4H), 3.71 (s, 3H).
References
[1] Patent: EP2256105, 2010, A1. Location in patent: Page/Page column 25; 26
[2] Patent: EP2471777, 2012, A1. Location in patent: Page/Page column 10
[3] Patent: US2009/36425, 2009, A1. Location in patent: Page/Page column 18
(4-OXO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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