ChemicalBook > CAS DataBase List > L371,257

L371,257

Product Name
L371,257
CAS No.
162042-44-6
Chemical Name
L371,257
Synonyms
257;L-371;L371,257;L371,257,L 371,257;1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one;1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine;2H-3,1-Benzoxazin-2-one, 1-[1-[4-[(1-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-piperidinyl]-1,4-dihydro-;1-(1-(4-((1-acetylpiperidin-4-yl)oxy)-2-methoxybenzoyl)piperidin-4-yl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
CBNumber
CB8850593
Molecular Formula
C28H33N3O6
Formula Weight
507.58
MOL File
162042-44-6.mol
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L371,257 Property

Boiling point:
728.9±60.0 °C(Predicted)
Density 
1.282±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
Soluble to 10 mM in DMSO with gentle warming
form 
Powder
pka
0.73±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3899
Product name
L-371,257
Purity
≥98% (HPLC)
Packaging
10mg
Price
$179
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3899
Product name
L-371,257
Purity
≥98% (HPLC)
Packaging
50mg
Price
$3200
Updated
2025/07/31
Tocris
Product number
2410
Product name
L-371,257
Purity
≥99%(HPLC)
Packaging
10
Price
$269
Updated
2021/12/16
Usbiological
Product number
255632
Product name
L-371,257
Packaging
10mg
Price
$516
Updated
2021/12/16
TRC
Product number
L352940
Product name
L-371,257
Packaging
1mg
Price
$160
Updated
2021/12/16
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L371,257 Chemical Properties,Usage,Production

Uses

L-371,257 is a potent antagonist of oxytocin-induced contractions of the rat uterus in vitro and in vivo and has significant oral bioavailability in rats.

Biological Activity

Potent, high affinity human oxytocin (OT) receptor antagonist (K i = 4.6 nM) that displays > 800-fold selectivity over human arginine vasopressin receptors V 1a and V 2 . Antagonizes oxytocin-induced contractions in isolated rat uterine tissue (pA 2 = 8.44) and in anesthetised rats following intravenous and intraduodenal administration. Orally active.

in vivo

Systemic administration of nonpenetrant oxytocin receptor antagonist L-371,257 (0.5 and 1.0 mg/kg; i.p. injection) stimulates weight gain in rats[3].

Animal Model:Six-hour fasted rats[3]
Dosage:0.5 and 1.0 mg/kg
Administration:Intraperitoneal injection (a single) 30-45 minutes prior to the start of the dark cycle and access to food; Intraperitoneal injection (given repeatedly) over 6 days.
Result:A single injection significantly stimulated weight gain at 0.5 and 1.0 mg/kg relative to vehicle treatment.
When given repeatedly over 6 days, 0.5 mg/kg significantly stimulated body weight gain (10.5±2.2 g) relative to vehicle treatment (4.7±2.7 g).

storage

Store at RT

L371,257 Preparation Products And Raw materials

Raw materials

Preparation Products

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162042-44-6, L371,257Related Search:

4-Cbz-Aminopiperidine 1-Acetyl-4-(methylamino)piperidine 4-Methoxysalicylamide 4-(4-METHYLPHENOXY)PIPERIDINE HYDROCHLORIDE 4-PHENOXYPIPERIDINE 4-[3-(Dimethylamino)propoxy]benzaldehyde 1-(4-ISOPROPOXYPHENYL)METHANAMINE 2,4-Dihydroxybenzamide 4-ANILINO-1-BENZYLPIPERIDINE 4-(3-METHOXYPHENOXY)PIPERIDINE 1-Acetylpiperidin-4-amine 4-(PIPERIDIN-4-YLOXY)BENZAMIDE (4-AMINO-PIPERIDIN-1-YL)-PHENYL-METHANONE Benzamide, N-(3-dimethylaminopropyl)-p-propoxy- 4-ETHOXY-N,N-DIETHYLBENZAMIDE CHEMBRDG-BB 9072047 4-AMINOCARBETHOXYPIPERIDINE 1-ACETYLPIPERIDIN-4-OL

  • L371,257
  • 1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine
  • 1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one
  • 2H-3,1-Benzoxazin-2-one, 1-[1-[4-[(1-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-piperidinyl]-1,4-dihydro-
  • 257
  • L-371
  • L371,257,L 371,257
  • 1-(1-(4-((1-acetylpiperidin-4-yl)oxy)-2-methoxybenzoyl)piperidin-4-yl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
  • 162042-44-6
  • C28H33N3O6