(E)-3-[3'-(4"-Fluorophenyl)-1'-(1"-methylethyl)-1H-indol-2"-yl]-2-propnal

Product Name: (E)-3-[3'-(4"-Fluorophenyl)-1'-(1"-methylethyl)-1H-indol-2"-yl]-2-propnal
CAS No.: 93957-50-7
Chemical Name: (E)-3-[3'-(4"-Fluorophenyl)-1'-(1"-methylethyl)-1H-indol-2"-yl]-2-propnal
Synonyms: (E)-3-[3'-(4;(E)-3-[3'-(4"Intermediate of Flurvastatin;Fluvastatin Aldehyde Impurity;Fluvastatin sodiuM interMediate F2;(E)-3-[3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-;(E)-3-[3-(4-Fluorophenyl)-1-isopropylindol-2-yl]propen;Fluorophenyl-1-Methylethyl-1H-indol-2-yl-(E)-2-propenal;(E)-3-[3-(4-Fluorophenyl)-1-isopropylindol-2-yl]propenal;(E)-3-[3-(4-Fluorophenyl)-1-isopropylindol-2-yl]acrolein
CBNumber: CB8855583
Molecular Formula: C20H18FNO
Formula Weight: 307.36
MOL File: 93957-50-7.mol

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(E)-3-[3'-(4"-Fluorophenyl)-1'-(1"-methylethyl)-1H-indol-2"-yl]-2-propnal Property

Melting point:: 129.0 to 133.0 °C
Boiling point:: 497.6±45.0 °C(Predicted)
Density: 1.10
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: powder to crystal
color: Light orange to Yellow to Green
InChI: InChI=1S/C20H18FNO/c1-14(2)22-18-7-4-3-6-17(18)20(19(22)8-5-13-23)15-9-11-16(21)12-10-15/h3-14H,1-2H3/b8-5+
InChIKey: DVWHSTKQJBIYCK-VMPITWQZSA-N
SMILES: C(=O)/C=C/C1=C(C2=CC=C(F)C=C2)C2=C(N1C(C)C)C=CC=C2
CAS DataBase Reference: 93957-50-7(CAS DataBase Reference)

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Safety

RIDADR: UN 3077 9/PG III
HS Code: 2933.99.8290
HazardClass: 9
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0819
Product name: (E)-3-[3-(4-Fluorophenyl)-1-isopropylindol-2-yl]acrolein
Purity: >98.0%(GC)
Packaging: 5g
Price: $133
Updated: 2025/07/31

TCI Chemical

Product number: F0819
Product name: (E)-3-[3-(4-Fluorophenyl)-1-isopropylindol-2-yl]acrolein
Purity: >98.0%(GC)
Packaging: 25g
Price: $396
Updated: 2025/07/31

AK Scientific

Product number: J95128
Product name: (E)-3-[3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl]-propenal
Packaging: 25g
Price: $100
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0050684
Product name: (E)-3-[3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOL-2-YL]-PROPENAL
Purity: 95.00%
Packaging: 5G
Price: $1347.37
Updated: 2021/12/16

Alichem

Product number: 93957507
Product name: (E)-3-(3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl)acrylaldehyde
Packaging: 100g
Price: $518.96
Updated: 2021/12/16

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(E)-3-[3'-(4"-Fluorophenyl)-1'-(1"-methylethyl)-1H-indol-2"-yl]-2-propnal Chemical Properties,Usage,Production

Uses

(E)-3-(3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl)acrylaldehyde is an intermediate in the synthesis of Fluvastatin (F601250), a synthetic HMG-CoA reductase inhibitor. Antilipemic.

Synthesis

34900-01-1

93957-49-4

93957-50-7

The general procedure for the synthesis of (E)-3-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)acrolein from the compound (CAS:34900-01-1) and 1-isopropyl-3-(4-fluorophenyl)indole is as follows: 1. A suspension of 3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indole (35.8 g) with phosphorus trichloride (31.4 g) in acetonitrile (35 ml) was cooled to 5 °C to prepare a crude acrolein solution. A 32.3 g solution of Example 3a in acetonitrile (40 ml) was added dropwise over 30 minutes. 2. the reaction mixture was gradually warmed to 60 °C and stirred at this temperature for 4 hours. 3. water (300 ml) was added and stirring was continued at 60 °C for 1 h. The solid formed was filtered through a Buchner funnel and washed with 75 ml of water. 4. The wet solid (49.7 g) was dissolved in toluene (250 ml), diatomaceous earth (1 g) and charcoal (0.5 g) were added and stirred for 30 minutes at room temperature. 5. After filtration of the solid, the solvent was removed by distillation under reduced pressure and the residue was dissolved in isopropanol (72 ml) at 75 °C. 6. The solution was cooled to 20 °C and stirred for 1 h at room temperature. 7. The precipitate was filtered through a Buchner funnel, washed twice with isopropanol (15 ml) and dried under vacuum at 60 °C. Finally 30.2 g (70% molar yield) of the target product was obtained. Example 4b 3-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-2-propenal was synthesized as follows: 1. A solution was prepared by cooling a suspension of 3-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indole (130.7 g) with phosphorus trichloride (114.6 g) in acetonitrile (128 ml) to 5 °C. 2. a solution of crude acrolein (116.9 g from Example 4a) in acetonitrile (145 ml) was added dropwise over 60 min. 3. the reaction mixture was gradually warmed to 60 °C and stirred at this temperature for 6 hours. 4. After addition of water (1100 ml) and continued stirring at 60 °C for 1 h, the solid formed was filtered through a Buchner funnel and washed with water (250 ml x 3). 5. The wet solid (131 g) was dissolved in toluene (1050 ml), diatomaceous earth (2.7 g) and charcoal (4 g) were added and stirred at room temperature for 30 min. 6. After filtration of the solid, the mixture was washed with water (500 ml x 2), the phases were separated and the organic solvent was removed by distillation under reduced pressure. 7. The residue was dissolved with isopropanol (260 ml) at 75 °C, the solution was cooled to 10 °C and stirred for 1 hour. 8. The precipitate was filtered through a Buchner funnel, washed with isopropanol (60 ml x 3) and dried under vacuum at 60 °C. A final 84.2 g (53% molar yield) of the target product was obtained.

References

[1] Patent: EP1477474, 2004, A1. Location in patent: Page column 5 - 6
[2] Journal of Organic Chemistry, 1992, vol. 57, # 11, p. 3250 - 3252
[3] RSC Advances, 2015, vol. 5, # 48, p. 38748 - 38759

(E)-3-[3'-(4"-Fluorophenyl)-1'-(1"-methylethyl)-1H-indol-2"-yl]-2-propnal Preparation Products And Raw materials

Raw materials

Preparation Products

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(E)-3-[3'-(4"-Fluorophenyl)-1'-(1"-methylethyl)-1H-indol-2"-yl]-2-propnal Suppliers

Americas 1 China 149 Europe 1 Germany 3 India 14 Japan 1 United Kingdom 2 United States 14 Global 185

Zhejiang Karry Pharmachem Co., Ltd.

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China Langchem Inc.

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View Lastest Price from (E)-3-[3'-(4"-Fluorophenyl)-1'-(1"-methylethyl)-1H-indol-2"-yl]-2-propnal manufacturers

Sichuan Zhuoyu Yantang Technology Co., Ltd.

Product: 1-Isopropyl-2-Acrolein-3- (4-fluorophenyl) -Indole 93957-50-7
Price: US $350.00/Kg/Bag
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 20ton
Release date: 2021-10-08

Hangzhou ICH Biofarm Co., Ltd

Product: (E)-3-[3'-(4"-fluorophenyl)-1'-(1"-methylethyl)-1H-indole-2"yl] prop-2-enal 93957-50-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 500
Release date: 2023-07-06

Shaanxi Dideu Medichem Co. Ltd

Product: 3-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-(F)-2-propenal 93957-50-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-11

93957-50-7, (E)-3-[3'-(4"-Fluorophenyl)-1'-(1"-methylethyl)-1H-indol-2"-yl]-2-propnalRelated Search:

(E)-3-(furan-2-yl)acrylic acid 3-(4-Fluorophenyl)-1-isopropyl-1H-indole Acrolein 1-ISOPROPYL-2-ACROLEIN-3-(4-FLUOROPHENYL)-INDOLE

(E)-3-[3-(4-Fluorophenyl)-1-isopropylindol-2-yl]acrolein

(E)-3-[3-(4-Fluorophenyl)-1-isopropylindol-2-yl]propenal

(E)-3-[3'-(4&quot

Fluvastatin sodiuM interMediate F2

Fluorophenyl-1-Methylethyl-1H-indol-2-yl-(E)-2-propenal

(E)-3-(3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl)acrylaldehyde

(E)-3-[3'-(4

3-(3-(4-FLUOROPHENYL)-1-(1-METHYL ETHYL)-1H-INDOL-2-YL)-2E-PROPENAL

(2E)-3-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-2-propenal

(e)-3-[3'-(4"-fluorophenyl)-1'-(1"-methylethyl)-1h-indol-2"-yl]-2-propnal

E-3-(3'-(4-Fluorophenyl)-1-(1'-Methylethyl)-1H-Indole-2-yl)-Prop-3-enaldehyde

(E)-3-[3-(4-Fluorophenyl)-1-(1-Methylethyl)-1H-Indole-2-yl] Propenal

(E)-3-[3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOL-2-YL]-PROPENAL

F2 (E)-3-[3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-1H-INDOLE-2-YL] PROPENAL

(E)-3-[3-(4-Fluorophenyl)-1-(isopropyl)-1h-indol-2-yl]-2-propenal

(E)-3-[3''-(4 -FLUOROPHENYL)-1''-(1-METHYLETHYL)-1H-INDOLE-2YL]PROP-2-ENAL

F2-(E)-3-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indole-2yl] prop-2-enal

(E)-3-[3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-

(E)-3-[3(4fluorophenyl)-1(1methylethyl)-1H-indole-2l]prop-2-enal

3-[3-(4-Fluorophenyl)-1-(1-Methylethyl)-1H-indol-2-yl]-(F)-2-propenal

(E)-3-[3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl]-propenal,93957-50-7,MFCD03840863.

(E)-3-[3-(4-Fluorophenyl)-1-(1-methylethyl)-2-indolyl]propenal

3-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]prop-1-en-1-one

3-[3-(4-Fluorophenyl)-1-(1-Methylethyl)-1H-indol-2-yl]-(E)-2-propenal

(E)-3-[3-(4-Fluorophenyl)-1-isopropylindol-2-yl]acrolein&gt

Fluvastatin Aldehyde Impurity

2-Propenal, 3-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-, (2E)-

(E)-3-[3'-(4"-Fluorophenyl)-1'-(1"-methylethyl)-1H-indol-2"-yl]-2-propnal USP/EP/BP

3-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-(E)-2...

(E)-3-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]prop-2-enal

(E)-3-[3-(4-Fluorophenyl)-1-isopropylindol-2-yl]propen

3- [3- (4-fluorophenyl) -1-isoprenyl-1, H-indole-2-yl] - acrolein

Intermediate of Flurvastatin

93957-50-7

91957-50-7

93957-50-0

Fluvastatin intermediates

Fluvastatine

Fluvastatin