ChemicalBook > CAS DataBase List > Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl-
Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl-
- Product Name
- Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl-
- CAS No.
- 1954650-11-3
- Chemical Name
- Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl-
- Synonyms
- JMS-053;Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl-;JMS-053 7-Imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione
- CBNumber
- CB88647551
- Molecular Formula
- C13H8N2O2S
- Formula Weight
- 256.28
- MOL File
- 1954650-11-3.mol
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Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl- Property
- Density
- 1.53±0.1 g/cm3(Predicted)
- pka
- 8.47±0.20(Predicted)
- form
- Solid
- color
- Light brown to brown
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Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl- Chemical Properties,Usage,Production
Description
JMS-053 is a potent inhibitor of the dual specificity phosphatase PTP4A3 that is potentially suitable for cancer therapy. JMS-053 markedly enhanced microvascular barrier function after exposure of endothelial cells to vascular endothelial growth factor or lipopolysaccharide. JMS-053 also blocked the concomitant increase in RhoA activation and loss of Rac1. In human ovarian cancer cells, JMS-053 impeded migration, disrupted spheroid growth, and decreased RhoA activity. Importantly, JMS-053 displayed anticancer activity in a murine xenograft model of drug resistant human ovarian cancer.
Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl- Preparation Products And Raw materials
Raw materials
Preparation Products
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