Indoramin Property

Melting point:

208-210°

Boiling point:

600.0±45.0 °C(Predicted)

Density 

1.21±0.1 g/cm3(Predicted)

pka

14.32±0.20(Predicted)

form 

Solid

color 

Off-white to light yellow

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

Indoramin Chemical Properties,Usage,Production

Originator

Baratol,Wyeth,UK,1981

Uses

Antihypertensive.

Definition

ChEBI: Indoramin is a member of tryptamines.

Manufacturing Process

4-Benzamido-1-[2-(3-indolyl)ethyl] pyridinium bromide (3.0 g) was dissolved in 91% ethanol (300 ml) containing triethylamine (0.08 g) and freshly prepared W7 Raney nickel catalyst (ca 3 g) was added. The mixture was hydrogenated in an autoclave at 400 psi hydrogen pressure and 50°C for 4 hours. After filtering off the catalyst the filtrate was evaporated in vacuo and the residue was shaken with a mixture of chloroform and 2N sodium hydroxide solution. The resulting insoluble material was filtered off and dried to give 1.61 g of product, MP 203°C to 206°C. Recrystallization from ethanol gave the title compound as colorless needles (1.34 g), MP 208°C to 210°C.

Therapeutic Function

Antihypertensive