ChemicalBook > CAS DataBase List > (R)-2-Phenylpyrrolidine

(R)-2-Phenylpyrrolidine

Product Name
(R)-2-Phenylpyrrolidine
CAS No.
56523-47-8
Chemical Name
(R)-2-Phenylpyrrolidine
Synonyms
56523-47-8;(R)-2-Phenylpyrrolidine;(2R)-2-phenylpyrrolidine;Pyrrolidine, 2-phenyl-, (2R)-
CBNumber
CB8875433
Molecular Formula
C10H13N
Formula Weight
147.22
MOL File
56523-47-8.mol
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(R)-2-Phenylpyrrolidine Property

Boiling point:
120 °C(Press: 6 Torr)
Density 
0.988±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
10.13±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P998488
Product name
(R)-2-Phenylpyrrolidine
Packaging
100mg
Price
$265
Updated
2021/12/16
AK Scientific
Product number
9228AJ
Product name
(R)-2-Phenylpyrrolidine
Packaging
250mg
Price
$278
Updated
2021/12/16
Activate Scientific
Product number
AS43654
Product name
(R)-2-Phenylpyrrolidine
Purity
95% ee
Packaging
250mg
Price
$342
Updated
2021/12/16
Activate Scientific
Product number
AS43654
Product name
(R)-2-Phenylpyrrolidine
Purity
95% ee
Packaging
100mg
Price
$171
Updated
2021/12/16
AK Scientific
Product number
9228AJ
Product name
(R)-2-Phenylpyrrolidine
Packaging
1g
Price
$616
Updated
2021/12/16
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(R)-2-Phenylpyrrolidine Chemical Properties,Usage,Production

Description

(R)-2-Phenylpyrrolidine is a boronic ester that can be administered orally. It has been shown to have nootropic and memory-enhancing activities in rats, but it does not have any known effects on kinase activities, amines, factor receptors, or synthetic activity.

Uses

(R)-2-Phenylpyrrolidine has also been shown to have prognostic value in cancer patients and can inhibit the growth of human cancer cells. This drug has been shown to bind to tropomyosin and growth factors with high affinity.

Definition

(R)-2-Phenylpyrrolidine is a novel class of selective pan-TRK inhibitors with efficacy in a KM12 rat tumor model. Since it was reported, this moiety has become a privileged TRK structure and was incorporated effectively in closely related scaffolds and on unrelated bicycle scaffolds. Its optimal shape complementarity to the TRK protein’s hydrophobic pocket available in the “DFG-in” conformation[1].

Origin

(R)-2-phenylpyrrolidine was first reported in 2008 by Ferrand S et al.

Properties and Applications

(R)-2-Phenylpyrrolidine is a yellow crystal,it is used as a pharmaceutical intermediate.

References

[1] Choi H, et al. (R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors. ACS Medicinal Chemistry Letters, 2015; 14: 562–567.

(R)-2-Phenylpyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-2-Phenylpyrrolidine manufacturers

Career Henan Chemica Co
Product
(R)-2-Phenylpyrrolidine 56523-47-8
Price
US $0.37/KG
Min. Order
1KG
Purity
99%
Supply Ability
10kg/100kg
Release date
2020-11-09

56523-47-8, (R)-2-PhenylpyrrolidineRelated Search:

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  • (R)-2-Phenylpyrrolidine
  • (2R)-2-phenylpyrrolidine
  • 56523-47-8
  • Pyrrolidine, 2-phenyl-, (2R)-
  • 56523-47-8
  • pharmaceutical intermediate
  • Chiral heterocyclic compounds