2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole

Product Name: 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
CAS No.: 78441-62-0
Chemical Name: 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
Synonyms: Einecs 278-909-9;Nizatidine intermediate;Nizatidine EP IMpurity D;Nizatidine Impurity 4(Nizatidine EP Impurity D);2-(2-(Dimethylaminomethyl-4-thiazol)methylthio)ethylamine; 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazol;2-(Dimethylaminomethyl)-4-(2-Aminoethylthionmethyl)Thiazole;4-(2-aminoethylthiomethyl)-1,3-thiazol-2-ylmethyldimethylamine;2-[[2-[(dimethylamino)methyl]-4-thiazolyl]methylthio]ethanamine;2-(((2-((methylamino)methyl)thiazol-4-yl)methyl)thio)ethanamine
CBNumber: CB8875695
Molecular Formula: C9H17N3S2
Formula Weight: 231.38
MOL File: 78441-62-0.mol

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2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole Property

Boiling point:: 338.9±37.0 °C(Predicted)
Density: 1.182±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 8.83±0.10(Predicted)
form: Oil to Thick Oil
color: Yellow to Very Dark Red

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D461050
Product name: 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
Packaging: 5g
Price: $640
Updated: 2021/12/16

TRC

Product number: D461050
Product name: 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
Packaging: 10g
Price: $1165
Updated: 2021/12/16

Matrix Scientific

Product number: 099411
Product name: 2-(((2-((Dimethylamino)methyl)thiazol-4-yl)methyl)thio)ethanamine
Purity: 95+%
Packaging: 5g
Price: $1183
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD22345
Product name: 2-[[2-(Dimethylaminomethyl)-1,3-Thiazol-4-Yl]Methylsulfanyl]Ethanamine
Packaging: 10g
Price: $1310.4
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0002062
Product name: 2-(DIMETHYLAMINOMETHYL)-4-(2-AMINOETHYLTHIOMETHYL)THIAZOLE
Purity: 95.00%
Packaging: 10G
Price: $2148.3
Updated: 2021/12/16

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2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole Chemical Properties,Usage,Production

Chemical Properties

Brown Liquid

Uses

2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole (Nizatidine EP Impurity D) is a Nizatidine intermediate.

Synthesis

156-57-0

140176-73-4

78441-62-0

General procedure for the synthesis of 2-(dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole from 2-mercaptoethylamine hydrochloride and 1,4-chloromethyl-2-dimethylaminothiazole hydrochloride: 2-aminoethanol hydrochloride (cysteamine hydrochloride, 520 g, 4.5 mol) was suspended in water (500 mL). This suspension was cooled to 5 °C and sodium hydroxide solution (45% w/w, 870 mL; 14.7 mol) was slowly added at 5-10 °C. Subsequently, hydroxylamine sulfate (100 g; 0.6 mol) was added to this suspension with continuous stirring. Another solution was prepared by dissolving 4-chloromethyl-2-dimethylaminomethylthiazole hydrochloride (1000 g; 4.43 mol) in water (1250 mL). The solution was slowly added to the above suspension while keeping the temperature below 10 °C and the reaction was continued at 10 °C for 1 hour. The reaction process was confirmed by qualitative HPLC monitoring. Upon completion of the reaction, the reaction mixture was diluted with water (2000 mL), heated to 40-45°C and extracted with toluene (2 x 2000 mL). The toluene extracts were combined and treated with activated charcoal at 40-45 °C for 30 min. The treated solution was filtered through a HYFLO bed to remove the activated carbon and the filtrate was evaporated at 60 °C under reduced pressure to remove toluene, resulting in 910 g of the target product in 88% yield.

References

[1] Patent: WO2004/69817, 2004, A1. Location in patent: Page 8

2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole manufacturers

Career Henan Chemical Co

Product: 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole 78441-62-0
Price: US $150.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2018-07-30

78441-62-0, 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazoleRelated Search:

Nizatidine EP IMpurity J Nizatidine EP IMpurity C Nizatidine EP IMpurity F 2-(DIMETHYLAMINO)ETHANETHIOAMIDE N-Methyl-1-(methylthio)-2-nitroethylen-1-amine 5,6-Dihydro-3-(MethylaMino)-2H-1,4-thiazin-2-one OxiMe Hydrochloride N-[2-[[[2-[(Dimethylamino)methyl]-4-thiazolyl]methyl]sulfinyl]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine N1,N1'-[2,4-Thiazolediylbis(Methylenethio-2,1-ethanediyl)]bis(N'-Methyl-2-nitro-1,1-ethenediaMine) N'-[2-[[[2-[(DiMethylaMino)Methyl]-4-thiazolyl]Methyl]thio]ethyl] Nizatidine N-desmethylnizatidine N,N'-dimethyl-2-nitro-1,1-ethenediamine Des(N'-Methyl-2-nitro-1,1-ethenediaMino) N'-Methylureido Nizatidine Nizatidine AMide 2-(DIMETHYLAMINOMETHYL)-4-THIAZOLEMETHANOL 1,3-Dichloroacetone 2-(Dimethylamino)thioacetamide hydrochloride Nizatidine Nizatidine EP IMpurity G

4-[[(2-aminoethyl)thio]methyl]-N,N-dimethylthiazole-2-methylamine

4-(2-aminoethylthiomethyl)-1,3-thiazol-2-ylmethyldimethylamine

2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazol

2-[[2-[(dimethylamino)methyl]-4-thiazolyl]methylthio]ethanamine

2-(((2-((DIMETHYLAMINO)METHYL)THIAZOL-4- L)METHYL)THIO)ETHANAMINE

Nizatidine intermediate

2-(Dimethylaminomethyl)-4-(2-Aminoethylthionmethyl)Thiazole

2-(2-(Dimethylaminomethyl-4-thiazol)methylthio)ethylamine

4-[[(2-Aminoethyl)thio]methyl]-N,N-dimethyl-2-thiazolemethanamine

2-Thiazolemethanamine, 4-(((2-aminoethyl)thio)methyl)-N,N-dimethyl-

Einecs 278-909-9

Nizatidine EP IMpurity D

2-(((2-((Dimethylamino)methyl)thiazol-4-yl)methyl)thio)ethanamine

2-(((2-((methylamino)methyl)thiazol-4-yl)methyl)thio)ethanamine

2-[(N,N-Dimethylamino)methyl]-4-[(2-aminoethyl)thiomethyl] thiazole

Nizatidine Impurity 4(Nizatidine EP Impurity D)

2-[[2-(Dimethylaminomethyl)-1,3-Thiazol-4-Yl]Methylsulfanyl]Ethanamine

2-[[[2-[(dimethylamino)methyl]thiazol-4-yl]methyl]sulfanyl]ethanamine

4-(2-AMINOETHYL) THIOMETHYL-2 DIMETHYLAMINOMETHYL THIAZOLE [NI5]

78441-62-0

C9H17N3S2

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds