2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
- Product Name
- 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
- CAS No.
- 78441-62-0
- Chemical Name
- 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
- Synonyms
- Einecs 278-909-9;Nizatidine intermediate;Nizatidine EP IMpurity D;Nizatidine Impurity 4(Nizatidine EP Impurity D);2-(2-(Dimethylaminomethyl-4-thiazol)methylthio)ethylamine; 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazol;2-(Dimethylaminomethyl)-4-(2-Aminoethylthionmethyl)Thiazole;4-(2-aminoethylthiomethyl)-1,3-thiazol-2-ylmethyldimethylamine;2-[[2-[(dimethylamino)methyl]-4-thiazolyl]methylthio]ethanamine;2-(((2-((methylamino)methyl)thiazol-4-yl)methyl)thio)ethanamine
- CBNumber
- CB8875695
- Molecular Formula
- C9H17N3S2
- Formula Weight
- 231.38
- MOL File
- 78441-62-0.mol
2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole Property
- Boiling point:
- 338.9±37.0 °C(Predicted)
- Density
- 1.182±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 8.83±0.10(Predicted)
- form
- Oil to Thick Oil
- color
- Yellow to Very Dark Red
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D461050
- Product name
- 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
- Packaging
- 5g
- Price
- $640
- Updated
- 2021/12/16
- Product number
- D461050
- Product name
- 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
- Packaging
- 10g
- Price
- $1165
- Updated
- 2021/12/16
- Product number
- 099411
- Product name
- 2-(((2-((Dimethylamino)methyl)thiazol-4-yl)methyl)thio)ethanamine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1183
- Updated
- 2021/12/16
- Product number
- FD22345
- Product name
- 2-[[2-(Dimethylaminomethyl)-1,3-Thiazol-4-Yl]Methylsulfanyl]Ethanamine
- Packaging
- 10g
- Price
- $1310.4
- Updated
- 2021/12/16
- Product number
- APN0002062
- Product name
- 2-(DIMETHYLAMINOMETHYL)-4-(2-AMINOETHYLTHIOMETHYL)THIAZOLE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $2148.3
- Updated
- 2021/12/16
2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole Chemical Properties,Usage,Production
Chemical Properties
Brown Liquid
Uses
2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole (Nizatidine EP Impurity D) is a Nizatidine intermediate.
Synthesis
156-57-0
140176-73-4
78441-62-0
General procedure for the synthesis of 2-(dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole from 2-mercaptoethylamine hydrochloride and 1,4-chloromethyl-2-dimethylaminothiazole hydrochloride: 2-aminoethanol hydrochloride (cysteamine hydrochloride, 520 g, 4.5 mol) was suspended in water (500 mL). This suspension was cooled to 5 °C and sodium hydroxide solution (45% w/w, 870 mL; 14.7 mol) was slowly added at 5-10 °C. Subsequently, hydroxylamine sulfate (100 g; 0.6 mol) was added to this suspension with continuous stirring. Another solution was prepared by dissolving 4-chloromethyl-2-dimethylaminomethylthiazole hydrochloride (1000 g; 4.43 mol) in water (1250 mL). The solution was slowly added to the above suspension while keeping the temperature below 10 °C and the reaction was continued at 10 °C for 1 hour. The reaction process was confirmed by qualitative HPLC monitoring. Upon completion of the reaction, the reaction mixture was diluted with water (2000 mL), heated to 40-45°C and extracted with toluene (2 x 2000 mL). The toluene extracts were combined and treated with activated charcoal at 40-45 °C for 30 min. The treated solution was filtered through a HYFLO bed to remove the activated carbon and the filtrate was evaporated at 60 °C under reduced pressure to remove toluene, resulting in 910 g of the target product in 88% yield.
References
[1] Patent: WO2004/69817, 2004, A1. Location in patent: Page 8
2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole manufacturers
- Product
- 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole 78441-62-0
- Price
- US $150.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-07-30