ChemicalBook > CAS DataBase List > Glycine, N-[4-[[2-(1-pyrrolidinyl)-4-pyrimidinyl]amino]phenyl]-N-[(2,4,6-trimethylphenyl)sulfonyl]-

Glycine, N-[4-[[2-(1-pyrrolidinyl)-4-pyrimidinyl]amino]phenyl]-N-[(2,4,6-trimethylphenyl)sulfonyl]-

Product Name
Glycine, N-[4-[[2-(1-pyrrolidinyl)-4-pyrimidinyl]amino]phenyl]-N-[(2,4,6-trimethylphenyl)sulfonyl]-
CAS No.
2355377-13-6
Chemical Name
Glycine, N-[4-[[2-(1-pyrrolidinyl)-4-pyrimidinyl]amino]phenyl]-N-[(2,4,6-trimethylphenyl)sulfonyl]-
Synonyms
DDO-5936;DDO-5936, 10 mM in DMSO;N-(Mesitylsulfonyl)-N-(4-((2-(pyrrolidin-1-yl)pyrimidin-4-yl)amino)phenyl)glycine;Glycine, N-[4-[[2-(1-pyrrolidinyl)-4-pyrimidinyl]amino]phenyl]-N-[(2,4,6-trimethylphenyl)sulfonyl]-;Inhibitor,DDO-5936,DDO 5936,colorectal,specific,inhibit,Glu47,potent,DDO5936,HSP,Heat shock proteins,Hsp90,cancer
CBNumber
CB88800341
Molecular Formula
C25H29N5O4S
Formula Weight
495.59
MOL File
2355377-13-6.mol
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Glycine, N-[4-[[2-(1-pyrrolidinyl)-4-pyrimidinyl]amino]phenyl]-N-[(2,4,6-trimethylphenyl)sulfonyl]- Property

Boiling point:
752.5±70.0 °C(Predicted)
Density 
1.361±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
Chloroform: Slightly Soluble: 0.1-1 mg/ml
DMSO: Sparingly Soluble: 1-10 mg/ml
form 
Solid
pka
3.12±0.10(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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Glycine, N-[4-[[2-(1-pyrrolidinyl)-4-pyrimidinyl]amino]phenyl]-N-[(2,4,6-trimethylphenyl)sulfonyl]- Chemical Properties,Usage,Production

Uses

DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. DDO-5936 can be used for the research of colorectal cancer[1].

Biological Activity

DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. DDO-5936 can be used for the research of colorectal cancer[1]. DDO-5936 is a Hsp90-Cdc37 PPI inhibitor with potency and specificity through binding to a critical site on Hsp90 involving Glu47[1]. DDO-5936 (0~80 mg/kg; p.o.) shows effect at the high dose group[1].DDO-5936 is well tolerated for the absence of serious weight loss. DDO-5936 high dose groups show that tumor cells in the xenografts decreased significantly. DDO-5936 shows limited oral efficiency[1].

in vivo

DDO-5936 (0~80 mg/kg; p.o.) shows effect at the high dose group[1].
DDO-5936 is well tolerated for the absence of serious weight loss. DDO-5936 high dose groups show that tumor cells in the xenografts decreased significantly. DDO-5936 shows limited oral efficiency[1].

Animal Model:Mice[1]
Dosage:0~80 mg/kg
Administration:P.o.
Result:Showed a moderate effect at the high dose group.

References

[1] Wang L, et al. Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer. J Med Chem. 2020;63(3):1281-1297.
[2] LEI WANG. Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer[J]. Science Advances, 2019, 5 9. DOI: 10.1126/sciadv.aax2277

Glycine, N-[4-[[2-(1-pyrrolidinyl)-4-pyrimidinyl]amino]phenyl]-N-[(2,4,6-trimethylphenyl)sulfonyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Glycine, N-[4-[[2-(1-pyrrolidinyl)-4-pyrimidinyl]amino]phenyl]-N-[(2,4,6-trimethylphenyl)sulfonyl]- Suppliers

China 39 United States 3 Global 42
Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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+86-25-83453306
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info@chemlin.com.cn
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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+86-400-002-6226 +86-13028896684;
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sales@rrkchem.com
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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15317229551
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ShangHai ChuanQian Chemcial Technique Centre
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15869524721
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cjbscvictory
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13348960310
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2355377-13-6, Glycine, N-[4-[[2-(1-pyrrolidinyl)-4-pyrimidinyl]amino]phenyl]-N-[(2,4,6-trimethylphenyl)sulfonyl]-Related Search:


  • Glycine, N-[4-[[2-(1-pyrrolidinyl)-4-pyrimidinyl]amino]phenyl]-N-[(2,4,6-trimethylphenyl)sulfonyl]-
  • DDO-5936
  • Inhibitor,DDO-5936,DDO 5936,colorectal,specific,inhibit,Glu47,potent,DDO5936,HSP,Heat shock proteins,Hsp90,cancer
  • DDO-5936, 10 mM in DMSO
  • N-(Mesitylsulfonyl)-N-(4-((2-(pyrrolidin-1-yl)pyrimidin-4-yl)amino)phenyl)glycine
  • 2355377-13-6