3-chloro-5-methoxyphenol
- Product Name
- 3-chloro-5-methoxyphenol
- CAS No.
- 65262-96-6
- Chemical Name
- 3-chloro-5-methoxyphenol
- Synonyms
- 65262-96-6;Einecs 265-661-1;3-Methoxy-5-chlorophenol;Phenol, 3-chloro-5-methoxy-;3-Chloro-5-methoxyphenol,99%
- CBNumber
- CB8880592
- Molecular Formula
- C7H7ClO2
- Formula Weight
- 158.58
- MOL File
- 65262-96-6.mol
3-chloro-5-methoxyphenol Property
- Melting point:
- 99℃
- Boiling point:
- 265.3±20.0 °C(Predicted)
- Density
- 1.280±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 8.63±0.10(Predicted)
- Appearance
- Light yellow to brown Solid
Safety
- HS Code
- 2909500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C381845
- Product name
- 3-Chloro-5-methoxyphenol
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC139543
- Product name
- 3-Chloro-5-methoxyphenol
- Packaging
- 500mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 119644
- Product name
- 3-Chloro-5-methoxyphenol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 2607-5-0G
- Product name
- 3-Chloro-5-methoxyphenol
- Packaging
- 1g
- Price
- $103
- Updated
- 2021/12/16
- Product number
- FC139543
- Product name
- 3-Chloro-5-methoxyphenol
- Packaging
- 1g
- Price
- $124
- Updated
- 2021/12/16
3-chloro-5-methoxyphenol Chemical Properties,Usage,Production
Uses
3-Chloro-5-methoxyphenol is a phenol derivative containing chloro and methoxy substituents on its benzene ring structure. The product can be used as a pharmaceutical intermediate.d
Synthesis
7051-16-3
65262-96-6
General procedure for the synthesis of 3-chloro-5-methoxyphenol from 1-chloro-3,5-dimethoxybenzene (Scheme No. 4, K): 1-methyl-2-pyrrolidinone (75 mL) was added to sodium methanethiol (12.32 g, 173.80 mmol) followed by 1-chloro-3,5-dimethoxybenzene (20.00 g, 115.87 mmol). The reaction mixture was heated to 140°C and maintained for 2.5 hours, followed by stirring at room temperature overnight. Upon completion of the reaction, 1-methyl-2-pyrrolidinone was removed by distillation under reduced pressure. The residue was partitioned between ethyl acetate, water and 1N hydrochloric acid. The organic layer was sequentially washed twice with 1N hydrochloric acid and once with saturated aqueous sodium chloride solution and then dried with anhydrous magnesium sulfate. The organic solvent was removed by concentration under reduced pressure to give a pale yellow solid. The solid was purified by silica gel column chromatography (400 mL silica gel, dichloromethane as eluent). The purified fraction was collected and the solvent was removed under reduced pressure to give 3-chloro-5-methoxyphenol as a yellow solid (16.62 g, 90% yield).1H NMR (300 MHz, DMSO-d6) δ 6.43 (t, J = 2.0 Hz, 1H), 6.40 (t, J = 1.9 Hz, 1H), 6.28 (t, J = 2.1 Hz, 1H), 6.28 (t, J = 2.1 Hz, 1H) 3.71 (s, 3H); MS (APCI+) m/z 159 [M+1]; Rf = 2.04 min.
References
[1] Patent: WO2007/149033, 2007, A1. Location in patent: Page/Page column 68-69
[2] Patent: WO2012/90219, 2012, A2. Location in patent: Page/Page column 91
3-chloro-5-methoxyphenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-chloro-5-methoxyphenol manufacturers
- Product
- 3-chloro-5-methoxyphenol 65262-96-6
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24