ChemicalBook > CAS DataBase List > 2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid

2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid

Product Name: 2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid
CAS No.: 68003-38-3
Chemical Name: 2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid
Synonyms: ABD7;ABD-7;ABD 7;Einecs 268-121-3;CTPI-2, 10 mM in DMSO;SLC25A1 inhibitor CTPI-2;2-(4-Chloro-3-nitrophenylsulfonamido)benzoic Acid;2-(4'-Chloro-3'-nitrobenzenesulfonamido)benzoic acid;2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid;Benzoic acid, 2-(((4-chloro-3-nitrophenyl)sulfonyl)amino)-
CBNumber: CB8884338
Molecular Formula: C13H9ClN2O6S
Formula Weight: 356.74
MOL File: 68003-38-3.mol

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2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid Property

Boiling point:: 564.8±60.0 °C(Predicted)
Density: 1.660±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:125 mg/mL(350.40 mM)
form: A solid
pka: 3.19±0.36(Predicted)
color: Off-white to light yellow
EPA Substance Registry System: Benzoic acid, 2-[[(4-chloro-3-nitrophenyl)sulfonyl]amino]- (68003-38-3)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3650
Product name: CTPI-2
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $81.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3650
Product name: CTPI-2
Purity: ≥98% (HPLC)
Packaging: 100mg
Price: $328
Updated: 2025/07/31

ChemScene

Product number: CS-0088164
Product name: CTPI-2
Purity: 98.80%
Packaging: 100mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-0088164
Product name: CTPI-2
Purity: 98.80%
Packaging: 250mg
Price: $150
Updated: 2021/12/16

AK Scientific

Product number: 3988BA
Product name: Benzoicacid,2-[[(4-chloro-3-nitrophenyl)sulfonyl]amino]-
Packaging: 250mg
Price: $264
Updated: 2021/12/16

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2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid Chemical Properties,Usage,Production

Uses

CTPI-2 is a third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a KD of 3.5 μM. CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet. Antitumor activity[1][2].

Biological Activity

CTPI-2 is a selective mitochondrial citrate transporter (SLC25A1) inhibitor th at displays H1299 anti-proliferation activity in a SLC25A1-dependent manner (IC50 <10 μM). When compared with CTPI-1, CTPI-2 exhibits 20-fold higher target affinity (hSLC25A1 KD = 3.5 μM vs. 63.6 μM, respectively) and is ~1000-fold more potent against H1299 sphere-forming capacity. CTPI-2 inhibits mitochondrial respiration and formation of patient NSCLC tumors-derived CSCs spheres in cultures (10-50 μM), as well as suppresses the growth of patent-derived NSCLC exnografts in mice in vivo (28 mg/kg q.o.d. i.p.).

in vivo

CTPI-2 is a unique regulator of glycolysis that limits the metabolic plasticity of cancer stem cells (CSCs). CTPI-2 (26 mg/kg; i.p.) inhibits tumor growth in in vivo models of non-small cell lung cancer (NSCLC)^[1].
CTPI-2 (50 mg/kg; i.p.; alternate days for 12 weeks) completely averts weight gain in the prevention study and leads to significant weight loss in the reversion study^[2].
CTPI-2 prevents steatohepatitis and normalizes glucose tolerance. CTPI-2 lowers the levels of circulating IL-6 while increasing anti-inflammatory IL-4 and IL-10 and also reduced the monocyte chemoattractant protein-1 and monokine-induced by interferon-γ that attract neutrophils and monocytes. CTPI-2 regulates the citrate pool, the lipogenic and the gluconeogenic pathways^[2].

Animal Model:	C57BL/6J mice (HFD-fed mice)^[2]
Dosage:	50 mg/kg
Administration:	Alternate days via the intraperitoneal route for 12 weeks
Result:	Completely averted weight gain in the prevention study and led to significant weight loss in the reversion study.

References

[1] Tan M, et al. Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. Cell Death Differ. 2020;27(7):2143-2157. DOI:10.1038/s41418-020-0491-6
[2] Fernandez HR, et al. The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer. Cell Death Differ. 2018;25(7):1239-1258. DOI:10.1038/s41418-018-0101-z

2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid Suppliers

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68003-38-3, 2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acidRelated Search:

2-(4-Chloro-3-nitrophenylsulfonylamino)benzenecarboxylic acid

2-(4'-Chloro-3'-nitrobenzenesulfonamido)benzoic acid

Benzoic acid, 2-(((4-chloro-3-nitrophenyl)sulfonyl)amino)-

Einecs 268-121-3

2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid

SLC25A1 inhibitor CTPI-2

macrophage,carrier,CTPI-2,NSCLC,transporter,glucose,steatohepatitis,CTPI 2,Mitochondrial Metabolism,steatosis,inflammatory,inhibit,citrate,Inhibitor,mitochondrial,CTPI2

2-(4-Chloro-3-nitrophenylsulfonamido)benzoic Acid

ABD 7

ABD7

ABD-7

CTPI-2, 10 mM in DMSO

68003-38-3