copper diundec-10-enoate
- Product Name
- copper diundec-10-enoate
- CAS No.
- 35322-29-3
- Chemical Name
- copper diundec-10-enoate
- Synonyms
- copper diundec-10-enoate;Bis(10-undecenoic acid)copper(II) salt
- CBNumber
- CB8886615
- Molecular Formula
- C22H38CuO4
- Formula Weight
- 430.08072
- MOL File
- 35322-29-3.mol
copper diundec-10-enoate Chemical Properties,Usage,Production
Uses
10-Undecenoic acid copper (Undecylenic acid copper) is an antifungal agent. 10-Undecenoic acid copper inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid copper has neuroprotective effects. 10-Undecenoic acid copper has anticancer effects on a variety of tumors. 10-Undecenoic acid copper inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid copper inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa[1][2][3][4][5][6][7][8].
in vivo
10-Undecenoic acid copper (arginine undecylenate (GS-1) form, 157.6 mg/mL; topical administration; twice a day; 6 days) effectively clears MRSA infections in the epidermal and dermal layers in a rat model of MRSA skin infection[8].
References
[1] Brayden D J, et al. Efficacious intestinal permeation enhancement induced by the sodium salt of 10-undecylenic acid, a medium chain fatty acid derivative[J]. The AAPS journal, 2014, 16: 1064-1076. DOI:10.1208/s12248-014-9634-3
[2] Day ZI, et al. Novel Formulation of Undecylenic Acid induces Tumor Cell Apoptosis. Int J Mol Sci. 2022 Nov 16;23(22):14170. DOI:10.3390/ijms232214170
[3] Kim MH, et al. Stimulatory effect of undecylenic acid on mouse osteoblast differentiation. Phytother Res. 2010 Apr;24(4):559-64. DOI:10.1002/ptr.2984
[4] Gon?alves LM, et al. Effects of undecylenic acid released from denture liner on Candida biofilms. J Dent Res. 2012 Oct;91(10):985-9. DOI:10.1177/0022034512458689
[5] Lee E, et al. Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of μ-calpain. Eur J Pharm Sci. 2012 May 12;46(1-2):17-25. DOI:10.1016/j.ejps.2012.01.015
[6] Jantas D, et al. An Involvement of PI3-K/Akt Activation and Inhibition of AIF Translocation in Neuroprotective Effects of Undecylenic Acid (UDA) Against Pro-Apoptotic Factors-Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells. J Cell Biochem. 2015 Dec;116(12):2882-95. DOI:10.1002/jcb.25236
[7] Fernandes S, et al. Curcumin and 10-Undecenoic acid copper as natural quorum sensing inhibitors of LuxS/AI-2 of Bacillus subtilis and LasI/LasR of Pseudomonas aeruginosa. Food Res Int. 2023 Mar;165:112519. DOI:10.1016/j.foodres.2023.112519
[8] Mayfosh A, et al. A Novel Ammonium Carboxylate Salt of Undecylenic Acid for the Topical Treatment of Gram-Positive and Antibiotic-Resistant Skin Infections. Exp Dermatol. 2025 Mar;34(3):e70075. DOI:10.1111/exd.70075